A multifunctional mesoporous silica–gold nanocluster hybrid platform for selective breast cancer cell detection using a catalytic amplification-based colorimetric assay

Li, Mingqiang; Lao, Yeh‐Hsing; Mintz, Rachel; Chen, Zhuang‐Gui; Shao, Dan; Hu, Hanze; Wang, Hongxia; Tao, Yu; Leong, Kam W.

doi:10.1039/c8nr08337a

Cited by 79 publications

(35 citation statements)

References 58 publications

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“…To further improve the detection sensitivity of nanozymebased pathological staining method, much effort has been expended to improve the enzyme-like catalytic activity of nanozymes, including adjusting their size, shape, composition, surface modification, and heteroatomic doping (Dong et al, 2014;Zhang et al, 2017;Jiang et al, 2019;Li et al, 2019). In 2018, Leong and co-workers engineered a mesoporous silicagold nanocluster hybrid nanozymes with excellent peroxidaselike catalytic activity for selective detection of HER2-positive (HER 2+ ) breast cancer cell .…”

Section: Nanozymes For Pathological Disease Diagnosismentioning

confidence: 99%

Nanozymes: A New Disease Imaging Strategy

Wang

Hong

et al. 2020

Front. Bioeng. Biotechnol.

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Nanozymes are nanomaterials with intrinsic enzyme-like properties. They can specifically catalyze substrates of natural enzymes under physiological condition with similar catalytic mechanism and kinetics. Compared to natural enzymes, nanozymes exhibit the unique advantages including high catalytic activity, low cost, high stability, easy mass production, and tunable activity. In addition, as a new type of artificial enzymes, nanozymes not only have the enzyme-like catalytic activity, but also exhibit the unique physicochemical properties of nanomaterials, such as photothermal properties, superparamagnetism, and fluorescence, etc. By combining the unique physicochemical properties and enzyme-like catalytic activities, nanozymes have been widely developed for in vitro detection and in vivo disease monitoring and treatment. Here we mainly summarized the applications of nanozymes for disease imaging and detection to explore their potential application in disease diagnosis and precision medicine.

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Section: Nanozymes For Pathological Disease Diagnosismentioning

confidence: 99%

Nanozymes: A New Disease Imaging Strategy

Wang

Hong

et al. 2020

Front. Bioeng. Biotechnol.

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“…Nanozyme is one type of nanomaterials with enzyme-like characteristics [162,163]. SOD and catalase mimics can detoxify various ROS, such as superoxide anion (O 2− ) and H 2 O 2 , which have been used in oxidative stress associated diseases [164][165][166].…”

Section: Nanozyme For Therapy Of Acute Liver Failurementioning

confidence: 99%

Applications of Nanobiomaterials in the Therapy and Imaging of Acute Liver Failure

Jin

Wang

et al. 2020

Nano-Micro Lett.

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Highlights This review focuses on the therapeutic mechanisms, targeting strategies of various nanomaterials in acute liver failure, and recent advances of diverse nanomaterials for acute liver failure therapy, diagnosis, and imaging. This review provides an outlook on the applications of nanomaterials, especially on the new horizons in acute liver failure therapy, and inspires broader interests across various disciplines. Abstract Acute liver failure (ALF), a fatal clinical disease featured with overwhelming hepatocyte necrosis, is a grand challenge in global health. However, a satisfactory therapeutic option for curing ALF is still absent, other than liver transplantation. Nanobiomaterials are currently being developed for the diagnosis and treatment of ALF. The liver can sequester most of nanoparticles from blood circulation, which becomes an intrinsic superiority for nanobiomaterials targeting hepatic diseases. Nanobiomaterials can enhance the bioavailability of free drugs, thereby significantly improving the therapeutic effects in ALF. Nanobiomaterials can also increase the liver accumulation of therapeutic agents and enable more effective targeting of the liver or specific liver cells. In addition, stimuli-responsive, optical, or magnetic nanomaterials exhibit great potential in the therapeutical, diagnostic, and imaging applications in ALF. Therefore, therapeutic agents in combination with nanobiomaterials increase the specificity of ALF therapy, diminish adverse systemic effects, and offer a multifunctional theranostic platform. Nanobiomaterial holds excellent significance and prospects in ALF theranostics. In this review, we summarize the therapeutic mechanisms and targeting strategies of various nanobiomaterials in ALF. We highlight recent developments of diverse nanomedicines for ALF therapy, diagnosis, and imaging. Furthermore, the challenges and future perspectives in the theranostics of ALF are also discussed.

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“…The attachment of oligonucleotide sequences complementary to the target DNA molecule to the surface of gold nanoparticles for the colorimetric detection of DNA is a relatively new diagnostic technique, presenting an alternative to fluorescent and radioimmune methods [7]. This technique can also be used for the detection of extremely low (atom-molar) concentrations of protein in biological media.…”

Section: Ae Volkov 1 Gv Reva 12 MV Slesarenko 1 Yv Gormentioning

confidence: 99%

VASCULAR RESPONSEs TO THE SUBCUTANEOUS INJECTION OF GOLD NANOPARTICLES

Волков¹,

Reva²,

Slesarenko³

et al. 2019

AREM

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The study presents the results of a study of the inhibitory role of gold nanoparticles, administered subcutaneously to mice line CBA. The migration paths of gold nanoparticles after subcutaneously injection have been studied, and the mechanisms of their influence on the tissue surrounding the injection site of nanoparticles have been examined. After subcutaneous injection, gold nanoparticles have been found to undergo phagocytosis by macrophages, some of which migrate to lymph node lymphoid follicles, and some enter the lumen of blood vessels, where nanoparticles exit the macrophage cytoplasm and enter the bloodstream. It has been established that as a result of the toxic effect of macrophages loaded with nanoparticles, the endothelium of the vessels growing into the tumor is destroyed. It was concluded that inhibition of angiogenesis and death of blood vessels in the tissues after the introduction of nanoparticles occurs in two ways. The first is not associated with direct inhibition of endothelial growth factor (VEGF), but with the deactivation of macrophages that produce VEGF, the molecules of which stimulate the formation of endothelium in growing blood vessels; and the second mechanism is implemented through the direct death of the endothelium during the migration of the macrophage through the vessel wall.

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A multifunctional mesoporous silica–gold nanocluster hybrid platform for selective breast cancer cell detection using a catalytic amplification-based colorimetric assay

Abstract: Breast cancer detection: The biosensor based on HER2 antibodies attached to MSN–AuNC hybrids is sensitive, selective, economical and simple to operate.

Cited by 79 publications

References 58 publications

Nanozymes: A New Disease Imaging Strategy

Nanozymes: A New Disease Imaging Strategy

Applications of Nanobiomaterials in the Therapy and Imaging of Acute Liver Failure

VASCULAR RESPONSEs TO THE SUBCUTANEOUS INJECTION OF GOLD NANOPARTICLES

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