A multifunctional nanocomposite coated with a BSA membrane for cascaded nitric oxide therapy

Ren, Rong; Bremner, David H.; Chen, Wenling; Shi, Anhua; Wang, Tong; Wang, Ying; Wang, Chengji; Wu, Junzi; Zhu, Li‐Min

doi:10.1016/j.ijbiomac.2023.124087

Cited by 9 publications

(3 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, the co-loading of two or more substances on the same carrier is a promising approach to exploit the cascade effect of multiple reactions developing efficient medical treatment. For example, Ren et al aimed to utilize gas therapy for cancer treatment; thus, they functionalized MPDA NPs with arginine and IR780, a photosensitizer for ROS production [97]. Indeed, radical species can degrade the amino acid into gaseous nitric oxide (NO).…”

Section: Morphology Role In Drug Deliverymentioning

confidence: 99%

Polydopamine Nanosystems in Drug Delivery: Effect of Size, Morphology, and Surface Charge

Menichetti,

Mordini,

Montalti

2024

Nanomaterials

View full text Add to dashboard Cite

Recently, drug delivery strategies based on nanomaterials have attracted a lot of interest in different kinds of therapies because of their superior properties. Polydopamine (PDA), one of the most interesting materials in nanomedicine because of its versatility and biocompatibility, has been widely investigated in the drug delivery field. It can be easily functionalized to favor processes like cellular uptake and blood circulation, and it can also induce drug release through two kinds of stimuli: NIR light irradiation and pH. In this review, we describe PDA nanomaterials’ performance on drug delivery, based on their size, morphology, and surface charge. Indeed, these characteristics strongly influence the main mechanisms involved in a drug delivery system: blood circulation, cellular uptake, drug loading, and drug release. The understanding of the connections between PDA nanosystems’ properties and these phenomena is pivotal to obtain a controlled design of new nanocarriers based on the specific drug delivery applications.

show abstract

Section: Morphology Role In Drug Deliverymentioning

confidence: 99%

Polydopamine Nanosystems in Drug Delivery: Effect of Size, Morphology, and Surface Charge

Menichetti,

Mordini,

Montalti

2024

Nanomaterials

View full text Add to dashboard Cite

show abstract

“…Indeed, since PDA often represents a support for the controlled release of other agents, it is very convenient to use it in a theragnostic system. For example, Ren and co-workers embedded agents for NO release and photothermal therapy (PTT) in mesoporous PDA (MPDA), exploiting its PAI efficiency [51]. MPDA was loaded with L-arginine as a NO donor and IR780 as a photosensitizer for ROS generation.…”

Section: Pda In Photoacoustic Imagingmentioning

confidence: 99%

Polydopamine-Based Nanoprobes Application in Optical Biosensing

Menichetti,

Mavridi-Printezi,

Mordini

et al. 2023

Biosensors

View full text Add to dashboard Cite

Polydopamine (PDA), the synthetic counterpart of melanin, is a widely investigated bio-inspired material for its chemical and photophysical properties, and in the last few years, bio-application of PDA and PDA-based materials have had a dramatic increase. In this review, we described PDA application in optical biosensing, exploring its multiple roles as a nanomaterial. In optical sensing, PDA can not only be used for its intrinsic fluorescent and photoacoustic properties as a probe: in some cases, a sample optical signal can be derived by melanin generation in situ or it can be enhanced in another material thanks to PDA modification. The various possibilities of PDA use coupled with its biocompatibility will indeed widen even more its application in optical bioimaging.

show abstract

“…L-arginine (LA) is a natural nitrogen donor with good biocompatibility and can be oxidized by H 2 O 2 to generate NO. LA in the H 2 O 2 -rich tumor microenvironment is expected to generate large amounts of intratumoral NO for gas therapy 17,18 .…”

Section: Introductionmentioning

confidence: 99%

Enhanced Breast Cancer Therapy Using Multifunctional Lipid- Coated Nanoparticles Combining Curcumin Chemotherapy and Nitric Oxide Gas Delivery

Yan,

Xiao,

et al. 2024

Preprint

View full text Add to dashboard Cite

The limitations of conventional treatment modalities for cancer, particularly breast cancer, have promoted the need to develop safer drug delivery systems (DDS). Chemotherapy combined with gas therapy has emerged as an attractive cancer treatment strategy. In this study, curcumin (Cur) loaded amorphous calcium carbonate nanoparticles (Cur-CaCO3) were prepared by gas diffusion reaction. A "one-step" ethanol injection method was then used to prepare lipid-coated calcium carbonate nanoparticles (Cur-CaCO3@LA-Lip) loaded with L-arginine (LA) to achieve a combination of chemotherapy and NO to enhance the antitumor effect. The prepared Cur-CaCO3@LA-Lip was characterized and evaluated by transmission electron microscopy (TEM), dynamic light scattering (DLS), UV-vis spectrometry, Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD) and differential scanning calorimetry (DSC). TEM observed that the Cur-CaCO3@LA-Lip nanoparticles were subspherical and had a distinct lipid layer covering the periphery. FTIR, XRD, and DSC indicated the successful synthesis of Cur-CaCO3@LA-Lip. Cur-CaCO3@LA-Lip exhibited a large drug loading capacity of 8.89% and 3.1% for Cur and LA, respectively, effectively preventing drug leakage. Furthermore, in vitro and in vivo, Cur-CaCO3@LA-Lip nanoparticles exhibited Cur sustained-release, high cellular uptake, high tumor accumulation, good biocompatibility, robust cytotoxicity, and antitumor efficacy.

show abstract

A multifunctional nanocomposite coated with a BSA membrane for cascaded nitric oxide therapy

Cited by 9 publications

References 65 publications

Polydopamine Nanosystems in Drug Delivery: Effect of Size, Morphology, and Surface Charge

Polydopamine Nanosystems in Drug Delivery: Effect of Size, Morphology, and Surface Charge

Polydopamine-Based Nanoprobes Application in Optical Biosensing

Enhanced Breast Cancer Therapy Using Multifunctional Lipid- Coated Nanoparticles Combining Curcumin Chemotherapy and Nitric Oxide Gas Delivery

Contact Info

Product

Resources

About