A multifunctional organophosphonic ligand-templated poly(polyoxotungstate) with potential in building a genosensor for thalassemia gene detection

Abstract

An organophosphonic ligand-templated PV–SbIII double-heteroatom-intercalated polyoxotungstate 1 was synthesized and the ability of the 1-based genosensor to detect the β-thalassemia gene was evaluated.

Advances in polyoxometalate-based electrochemical sensors in the last three years

“…So far, the common electrochemical methods for generating read-out detection signals include cyclic voltammetry (CV), differential pulse voltammetry (DPV), square wave voltammetry (SWV), electrochemical impedance spectroscopy (EIS), chronoamperometry ( i – t curve) and electrochemiluminescence (ECL) (Table 1). 33–60 In this section, we will mainly focus on testing the principles of POM-based ECSs based on redox reactions (referred to as redox ECSs in this review), aptasensors and immunosensors, respectively.…”

“…Developing POM-based ECSs for important applications in the biomedical field has been an emerging and booming theme in recent years. Up to now, POM-based ECSs have been successfully applied in recognizing hormones, 44,62,82,83 biomarkers, 70,84–87 drugs, 51,60,88,89 gene segments, 43,50,55 etc. , providing strong support for health monitoring, early diagnosis and treatment of diseases.…”

“…Through an electropolymerization process, they prepared a 17 -PEDOT hybrid film, featuring outstanding electrical conductivity and stability. 50 On this basis, the 17 -PEDOT/GCE provides a favorable platform for β-thalassemia gene detection (LOD = 0.26 pM). In these reported POM-based genosensors, the complementary DNA (c-DNA) for the target DNA was used as the probe and was immobilized on the electrode surface via Au–S bonds, realizing the specific recognition of the target DNA sequence.…”