Since the COVID-19 pandemic outbreak a growing body of literature has observed uncertainty among the main factors driving investor behavior, with these becoming more likely to seek risk minimization strategies, such as the minimum variance approach based on Modern Portfolio Theory. In this chapter a network-based minimum variance approach to portfolio diversification is carried out with assets from Latin America's five largest stock exchanges between 2018 and 2021. Global Minimum Variance Portfolios are obtained with the use of structural information contained in partial-correlation networks and a community detection process. The main objective is the investigation of the implications of the pandemic on minimum variance diversification in the region through an analysis of portfolio asset selection and allocation results, including risk and return performance, benchmarked against naïve investment portfolios.