A multimodal sensor system for automated marmoset behavioral analysis

Brattain, Laura J.; Landman, Rogier; Johnson, Kristina T.; Chwalek, Patrick; Hyman, Julia; Sharma, Jitendra; Jennings, Charles; Desimone, Robert; Feng, Guoping; Quatieri, Thomas F.

doi:10.1109/bsn.2016.7516269

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…In particular, the posture of animals -a series of movements of the major body parts -reflects both motor function and their internal state such as emotion and intention (Dael et al, 2012;Coulson, 2004;Matsumoto et al, 2013Matsumoto et al, , 2014Mimura et al, 2015;Nakamura et al, 2016). Conventional systems available for marmosets focus on simple macroscale parameters (e.g., circadian activity rhythms (Yabumoto et al, 2019)) or a few microbehavioral parameters (e.g., eye and face orientation (Brattain et al, 2016;Turesson et al, 2016)). We developed a markerless MTS that tracks and digitizes the 3D trajectory of the major body parts of marmosets, thereby reconstructing and analyzing the sequence of posture.…”

Section: Ll Open Accessmentioning

confidence: 99%

Chemogenetic activation of nigrostriatal dopamine neurons in freely moving common marmosets

et al. 2021

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To interrogate particular neuronal pathways in nonhuman primates under natural and stress-free conditions, we applied designer receptors exclusively activated by designer drugs (DREADDs) technology to common marmosets. We injected adeno-associated virus vectors expressing the excitatory DREADD hM3Dq into the unilateral substantia nigra (SN) in four marmosets. Using multi-tracer positron emission tomography imaging, we detected DREADD expression in vivo, which was confirmed in nigrostriatal dopamine neurons by immunohistochemistry, as well as by assessed activation of the SN following agonist administration. The marmosets rotated in a contralateral direction relative to the activated side 30-90 min after consuming food containing the highly potent DREADD agonist deschloroclozapine (DCZ) but not on the following days without DCZ. These results indicate that non-invasive and reversible DREADD manipulation will extend the utility of marmosets as a primate model for linking neuronal activity and natural behavior in various contexts.

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Section: Ll Open Accessmentioning

confidence: 99%

Chemogenetic activation of nigrostriatal dopamine neurons in freely moving common marmosets

et al. 2021

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“…The work reported here expands on knowledge gained from these previous studies to design a wireless module built on a flexible circuit substrate that conforms comfortably to the neck surface and aids in subject compliance and alleviates the cumbersome cable management needed for wired devices. An early prototype of the wireless module was initially reported by our group as part of a comprehensive multimodal system for animal behavior monitoring [10]; the module has since undergone significant improvements and optimization for human speech analysis for the current study.…”

Section: Acoustic and Non-acoustic Sensorsmentioning

confidence: 99%

Wireless Neck-Surface Accelerometer and Microphone on Flex Circuit with Application to Noise-Robust Monitoring of Lombard Speech

et al. 2017

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Ambulatory monitoring of real-world voice characteristics and behavior has the potential to provide important assessment of voice and speech disorders and psychological and emotional state. In this paper, we report on the novel development of a lightweight, wireless voice monitor that synchronously records dual-channel data from an acoustic microphone and a necksurface accelerometer embedded on a flex circuit. In this paper, Lombard speech effects were investigated in pilot data from four adult speakers with normal vocal function who read a phonetically balanced paragraph in the presence of different ambient acoustic noise levels. Whereas the signal-to-noise ratio (SNR) of the microphone signal decreased in the presence of increasing ambient noise level, the SNR of the accelerometer sensor remained high. Lombard speech properties were thus robustly computed from the accelerometer signal and observed in all four speakers who exhibited increases in average estimates of sound pressure level (+2.3 dB), fundamental frequency (+21.4 Hz), and cepstral peak prominence (+1.3 dB) from quiet to loud ambient conditions. Future work calls for ambulatory data collection in naturalistic environments, where the microphone acts as a sound level meter and the accelerometer functions as a noise-robust voicing sensor to assess voice disorders, neurological conditions, and cognitive load.

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“…The growing popularity of 54 marmosets stems from their similarity to humans regarding the disease susceptibility 55 profile [11,55], their relative ease of handling, high fecundity and fast development [43], 56 and the recent development of key tools for genetic manipulations [44,48] and 57 neuroscience experiments [37]. To the best of our knowledge, only one publication has 58 reported on a preliminary method for automated behavioral tracking of marmosets [6]. 59 In contrast to rodents, primates in general have to orient their gaze precisely which 60 makes gaze direction informative of what they pay attention to [33,49].…”

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confidence: 99%

Head and gaze tracking of unrestrained marmosets

Turesson

Conceicao

Ribeiro

2016

Preprint

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New technologies for manipulating and recording the nervous system allow us to 1 perform unprecedented experiments. However, the influence of our experimental 2 manipulations on psychological processes must be inferred from their effects on 3 behavior. Today, quantifying behavior has become the bottleneck for large-scale, high 4 throughput, experiments. The method presented here addresses this issue by using deep 5 learning algorithms for video-based animal tracking. Here we describe a reliable 6 automatic method for tracking head position and orientation from simple video 7 recordings of the common marmoset (Callithrix jacchus). This method for measuring 8 marmoset behavior allows for the indirect estimation of gaze within foveal error, and 9 can easily be adapted to a wide variety of similar tasks in biomedical research. In 10 particular, the method has great potential for the simultaneous tracking of multiple 11 marmosets to quantify social behaviors. 12 Introduction 13Recent technological developments allow us to manipulate [3,35,40] and record [7,9,53] 14 the nervous system with historically unprecedented precision and scale. Yet, the 15 psychological relevance of our sophisticated manipulations and large-scale recordings 16 can only be inferred from their effect on behavior. Today, quantifying behavior has 17 become the bottleneck for high-throughput experiments [5,48]. Common practice is to 18 apply standard tests designed to measure psychological constructs such as anxiety and 19 memory, for example, by using the Elevated Plus Maze [34] or the Morris Water 20 Maze [28]. Such testing requires animals to be individually handled, making data 21 acquisition labor intensive, increasing costs and reducing experimental throughput. 22Alternatively, various simple detectors (e.g. capacitance sensors or photo-beams) can be 23 arranged to automatically acquire data at specific sites (e.g. drinking [12] and 24 feeding [10] stations). This type of automatization allows for high throughput, but fails 25 to capture complex or subtle behaviors such as social interactions and gaze behaviors. A 26 more promising approach is to record high-dimensional data from sensor arrays (e.g. 27video) and extract relevant information using computer vision algorithms. This 28 approach has the potential to provide a better characterization of behavior, capable of 29 automatically capturing complex and subtle behaviors, while simultaneously reducing 30 both cost and labor intensity [39]. Raw video frames are composed of a high number of 31 pixels whose values do not straightforwardly correlate with an animal's behavior. In

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A multimodal sensor system for automated marmoset behavioral analysis

Cited by 4 publications

References 26 publications

Chemogenetic activation of nigrostriatal dopamine neurons in freely moving common marmosets

Chemogenetic activation of nigrostriatal dopamine neurons in freely moving common marmosets

Wireless Neck-Surface Accelerometer and Microphone on Flex Circuit with Application to Noise-Robust Monitoring of Lombard Speech

Head and gaze tracking of unrestrained marmosets

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