A multiple drug-resistant Streptococcus pneumoniae of serotype 15A occurring from serotype 19A by capsular switching

Savinova, Tatiana; Brzhozovskaya, Ekaterina; Shagin, Dmitry A.; Mikhaylova, Yuliya V.; Shelenkov, Andrey; Yanushevich, Yurii G.; Mayanskiy, Nikolay

doi:10.1016/j.vaccine.2020.05.075

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…To our knowledge, recent data of postvaccine dynamics of serogroup 15, as well as its association with CFR, are scarce. Savinola et al ( 34 ) described the emergence of a 15A multidrug-resistant lineage as a result from a 19A capsule switch and van der Linden et al ( 35 ) showed an increase in 15A after PCV-13 introduction in Germany. An increase of serogroup 15 in children with pneumococcal disease was noted in Hong Kong; Liyanapathirana et al suggested consideration in future vaccine strategies ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

Streptococcus pneumoniae Serotypes Associated with Death, South Africa, 2012–2018

Müller¹,

Kleynhans²,

Gouveia³

et al. 2022

Emerg. Infect. Dis.

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The Streptococcus pneumoniae polysaccharide capsule plays a role in disease severity. We assessed the association of serotype with case-fatality ratio (CFR) in invasive pneumococcal disease (IPD) and meningitis in South Africa, 2012–2018 (vaccine era), using multivariable logistic regression by manual backward elimination. The most common serotypes causing IPD were 8 and 19A. In patients <15 years of age, serotypes associated with increased CFR in IPD, compared with serotype 8 and controlling for confounding factors, were 11A, 13, 19F, 15A, and 6A. None of these serotypes were associated with increased CFR in meningitis. Among IPD patients > 15 years of age, serotype 15B/C was associated with increased CFR. Among meningitis patients of all ages, serotype 1 was associated with increased CFR. PCV13 serotypes 1, 3, 6A, 19A, and 19F should be monitored, and serotypes 8, 12F, 15A, and 15B/C should be considered for inclusion in vaccines to reduce deaths caused by S. pneumoniae .

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Section: Discussionmentioning

confidence: 99%

Streptococcus pneumoniae Serotypes Associated with Death, South Africa, 2012–2018

Müller¹,

Kleynhans²,

Gouveia³

et al. 2022

Emerg. Infect. Dis.

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“…The shared ST of serotype 19A/ST63 (n=2) and 15A/ST63 (n=13) isolates, in addition to their similar AMR profile, is suggestive of a serotype switching event. Multiple examples of vaccine evasion via serotype switching to 15A (a serotype not contained in the either the 13v-PCV or the 23v-PPV) have been documented [45,46]. Although serotype 15B is contained in the 23v-PPV and is to be included in other PCVs in development that contain a broader selection of serotypes, 15B immunity has not been shown to provide cross-protection to 15A [47].…”

Section: Discussionmentioning

confidence: 99%

Population structure, serotype distribution and antibiotic resistance of Streptococcus pneumoniae causing invasive disease in Victoria, Australia

et al. 2023

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Streptococcus pneumoniae is a major human pathogen and can cause a range of conditions from asymptomatic colonization to invasive pneumococcal disease (IPD). The epidemiology and distribution of IPD-causing serotypes in Australia has undergone large changes following the introduction of the 7-valent pneumococcal conjugate vaccine (PCV) in 2005 and the 13-valent PCV in 2011. In this study, to provide a contemporary understanding of the IPD causing population in Victoria, Australia, we aimed to examine the population structure and prevalence of antimicrobial resistance using whole-genome sequencing and comprehensive antimicrobial susceptibility data of 1288 isolates collected between 2018 and 2022. We observed high diversity among the isolates with 52 serotypes, 203 sequence types (STs) and 70 Global Pneumococcal Sequencing Project Clusters (GPSCs) identified. Serotypes contained in the 13v-PCV represented 35.3 % (n=405) of isolates. Antimicrobial resistance (AMR) to at least one antibiotic was identified in 23.8 % (n=358) of isolates with penicillin resistance the most prevalent (20.3 %, n=261 using meningitis breakpoints and 5.1 % n=65 using oral breakpoints). Of the AMR isolates, 28 % (n=101) were multidrug resistant (MDR) (resistant to three or more drug classes). Vaccination status of cases was determined for a subset of isolates with 34 cases classified as vaccine failure events (fully vaccinated IPD cases of vaccine serotype). However, no phylogenetic association with failure events was observed. Within the highly diverse IPD population, we identified six high-risk sub-populations of public health concern characterized by high prevalence, high rates of AMR and MDR, or serotype inclusion in vaccines. High-risk serotypes included serotypes 3, 19F, 19A, 14, 11A, 15A and serofamily 23. In addition, we present our data validating seroBA for in silico serotyping to facilitate ISO-accreditation of this test in routine use in a public health reference laboratory and have made this data set available. This study provides insights into the population dynamics, highlights non-vaccine serotypes of concern that are highly resistant, and provides a genomic framework for the ongoing surveillance of IPD in Australia which can inform next-generation IPD prevention strategies.

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“…В работе российских ученых T. Savinova с соавт. [28] указано, что серотип 15A является одним из ведущих серотипов S. pneumoniae, не входящих в состав вакцины. С помощью полногеномного секвенирования ученые обнаружили пневмококк серотипа 15A с множественной лекарственной устойчивостью, возникший в результате явления «переключения капсулы» (capsule switching) с серотипа 19A/ST276.…”

Section: характеристика серотипов пневмококка планируемых к включению...unclassified

Analysis of pneumococcal serotypes distribution to determine a model composition for a Russian pneumococcal conjugate vaccine

Трухин¹,

Evtushenko²,

Салимова³

et al. 2022

Biological Products. Prevention, Diagnosis, Treatment

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Diseases caused by Streptococcus pneumoniae, as well as antibiotic resistance of its serotypes, are the leading cause of death amongst children worldwide. To prevent pneumococcal infection, the population is immunised with conjugate vaccines containing different amounts of polysaccharides of certain serotypes. Development of a full-cycle Russian vaccine is vital because the active pharmaceutical ingredients for the vaccines registered in the Russian Federation are produced abroad, and only the final stages of production of vaccines of this group are performed in the territory of the Russian Federation. Considering the phenomenon of serotype replacement associated with the long-term widespread use of pneumococcal conjugate vaccines, it is necessary to carefully select the serotype composition for the new vaccine. The aim of this work was to analyse the serotype distribution of pneumococci in the Russian Federation and other countries in order to select optimal serotypes for the Russian vaccine for human use, taking into account vaccination schedules for each age group. This review presents an analysis of the pneumococcal serotype distribution in the Russian Federation in the pre-vaccination era, as well as after the introduction of routine vaccination. In addition, the review includes data on the serotype distribution in the Eurasian Economic Union countries. The authors described a model composition containing at least sixteen serotypes. It will increase effectiveness of immune protection of the population, providing a more complete coverage of serotypes, considering their prevalence in the Russian Federation. Based on the analysis, the serotype composition for the sixteen-valent pneumococcal conjugate vaccine is proposed for further production and preclinical and clinical trials. A new Russian pneumococcal conjugate vaccine will ensure vaccination of all population groups within the National Immunisation Schedule of the Russian Federation.

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A multiple drug-resistant Streptococcus pneumoniae of serotype 15A occurring from serotype 19A by capsular switching

Cited by 5 publications

References 17 publications

Streptococcus pneumoniae Serotypes Associated with Death, South Africa, 2012–2018

Streptococcus pneumoniae Serotypes Associated with Death, South Africa, 2012–2018

Population structure, serotype distribution and antibiotic resistance of Streptococcus pneumoniae causing invasive disease in Victoria, Australia

Analysis of pneumococcal serotypes distribution to determine a model composition for a Russian pneumococcal conjugate vaccine

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