2020 IEEE International Ultrasonics Symposium (IUS) 2020
DOI: 10.1109/ius46767.2020.9251762
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A multiplexed microfluidic and microscopy study of vasodilation signaling pathways using microbubble and ultrasound therapy

Abstract: In solid tumors, hypoxia is a well-known resistance mechanism to radiation therapy. It was previously shown that microbubbles (MBs), when exposed to an ultrasound pulse (US) can cause vasodilation in muscle tissue. Conceptually, the therapeutic pulse can be localized on the tumor by steering the US beam. This approach is therefore proposed as a targeted image-guided provascular therapy in tumors to reduce hypoxia before radiotherapy. However, the effects of US and MB conditions on the relative increase in tumo… Show more

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