“…Economic growth has led to serious degradation of water quality, in particular due to the emission of nutrients from urban and rural sources, resulting in increasing eutrophication and outbreaks of harmful algal blooms (HABs) (Carpenter, 2008; Cornwell et al., 2015; McKindles et al., 2020; Michalak et al., 2013; Watson et al., 2016), jeopardizing water security and compromising the long‐term sustainability of the social and economic activities in the GLB (Isely et al., 2018; Smith et al., 2019). In view of the fact that the economic activities in the GLB are highly interdependent and connected to other regions across the country and internationally (Garcia‐Hernandez & Brouwer, 2020), changes in one activity to reduce the emission of nutrients are expected to impact other activities inside and outside the GLB. In order to be able to better understand the interconnectivity of these various water‐dependent activities in the economy as a whole and assess the wider direct and indirect economic impacts of nutrient reduction policies, an appropriate multi‐regional macro‐economic modeling framework is required.…”