A multiresidue procedure for the determination and confirmation of acidic herbicide residues in human urine

Draper, William M.

doi:10.1021/jf00110a004

Cited by 21 publications

(2 citation statements)

References 7 publications

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“…Recoveries were 80-104 percent for fortifications at 0.1 mg/L, and detection limits for herbicides in urine were 0.05--0.1 mg/L by EC-GC, and 0.1-0.5 mg/L by GC-MS. Methylation of urinary extracts was found superior (344) to (pentafl uorophenyl )methylation (318).…”

Section: Additional Recent Results On Analysis Of Pesticidesmentioning

confidence: 96%

Priority toxic pollutants in human urine :

Fatiadi¹

1983

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Section: Additional Recent Results On Analysis Of Pesticidesmentioning

confidence: 96%

Priority toxic pollutants in human urine :

Fatiadi¹

1983

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“…Although some pesticides are metabolized rapidly in the body and excreted in urine within 48 h [16], various chemical groups of pesticides still remain intact and present in urine [17,18,19,20]. It is easier and less costly to obtain analytical standards of pesticides rather than those of metabolites.…”

Section: Introductionmentioning

confidence: 99%

A Quantitative Tandem Mass Spectrometry and Scaled-Down QuEChERS Approach for Simultaneous Analysis of Pesticide Multiresidues in Human Urine

et al. 2019

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Multiresidual pesticide determination in a biological sample is essential for an immediate decision and response related to various pesticide intoxications. A rapid and simultaneous analytical method for 260 pesticides in human urine was developed and validated using liquid chromatography-tandem mass spectrometry (LC-MS/MS). High speed positive/negative switching electrospray ionization (ESI) mode was used, and scheduled multiple reaction monitoring (MRM) was optimized. Three versions of scaled-down QuEChERS procedures were evaluated, and the procedure using non-buffer reagents (magnesium sulfate and sodium chloride) and excluding cleanup steps was selected for optimum pesticide extraction. The limit of quantitation (LOQ) in this methodology was 10 ng/mL for each target pesticide, and correlation coefficient (r2) values of calibration curves were ≥0.988 (linearity range; 10–250 ng/mL). In accuracy and precision tests, the relative error ranges were −18.4% to 19.5%, with relative standard deviation (RSD) 2.1%–19.9% at an LOQ level (10 ng/mL), and −14.7% to 14.9% (RSD; 0.6%–14.9%) at higher concentrations (50, 150, and 250 ng/mL). Recovery range was 54.2%–113.9% (RSD; 0.3%–20.0%), and the soft matrix effect (range; −20% to 20%) was observed in 75.4% of target pesticides. The established bioanalytical methods are sufficient for application to biomonitoring in agricultural exposures and applicable in the forensic and clinic.

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Zur Analytik von Chlorphenoxyalkansäuren und Chlorphenolen. Teil 2: Nachweis von Chlorphenoxyalkansäuren und Chlorphenolen in der Fischgalle

Grahl¹,

Hermenau²

1984

Acta hydrochim. hydrobiol.

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S"um/nary: The bile liquid is preserved with ethanol and the protein is precipitated. Prefractionating is done by liquid-liquid Pxtraction by chloroform and ethyl aceta.t,e. The extra& are eo-1 nmn-chromatographically separated on Florisil and subsequently detect,ed by t hin-layer chromatography. For determining the identit,g of substances, the penta fluorobenzyl derivatives are prepared and chromatographed under the same conditions. Detection is carried out. with the aid of aiiinioiiiacal silver nitrate reagency and ultraviolet irradiat,ion. The highly polar conjugates of chlorophenoxyalkane acids and chlorophenols which are present in the bile are cracked by acid hydrolysis and then cleaned by re-extraction. I n this way, 2, 4-D, MCPA, MCPP, 2,4-dichlorophenol and 2-methyl-4-chlorophenol were detected from Salmo gnirdneri. 6 ... 21 d after t,he application of t,he herbicides in the catchment area their concentration in the fish bile amounted to about 200 mgil, 90 O;,, of them having been conjiipat,es. Thus, the biliary excretion of xenobiotic substances offers an important new aspect of biomonitoring by means of fish tests, especially in the raiige of subacute and chronic toxicity.

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A multiresidue procedure for the determination and confirmation of acidic herbicide residues in human urine

Cited by 21 publications

References 7 publications

Priority toxic pollutants in human urine :

Priority toxic pollutants in human urine :

A Quantitative Tandem Mass Spectrometry and Scaled-Down QuEChERS Approach for Simultaneous Analysis of Pesticide Multiresidues in Human Urine

Zur Analytik von Chlorphenoxyalkansäuren und Chlorphenolen. Teil 2: Nachweis von Chlorphenoxyalkansäuren und Chlorphenolen in der Fischgalle

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