A multiscale framework for large deformation modeling of RBC membranes

Ademiloye, Adesola; Zhang, Luwen; Liew, K.M.

doi:10.1016/j.cma.2017.10.004

Cited by 18 publications

(13 citation statements)

References 55 publications

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“…Therefore, the RBC deformability is a potential measure of cell viability subjected to morphological, structural and functional changes, and provide valuable insights into the physiology, cell biology and biorheology under pathophysiological conditions. Different techniques have been used to investigate RBC deformability, and descriptions of these techniques can be found in [17,25,29,33,42,43,47,[57][58][59][60][61][62][63][64][65][66][67][68][69][70]. Optical tweezers is one such technique and provides a highly sensitive assessment of the cell deformability at the single cell level.…”

Section: Introductionmentioning

confidence: 99%

Modelling of Red Blood Cell Morphological and Deformability Changes during In-Vitro Storage

et al. 2020

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Storage lesion is a critical issue facing transfusion treatments, and it adversely affects the quality and viability of stored red blood cells (RBCs). RBC deformability is a key indicator of cell health. Deformability measurements of each RBC unit are a key challenge in transfusion medicine research and clinical haematology. In this paper, a numerical study, inspired from the previous research for RBC deformability and morphology predictions, is conducted for the first time, to investigate the deformability and morphology characteristics of RBCs undergoing storage lesion. This study investigates the evolution of the cell shape factor, elongation index and membrane spicule details, where applicable, of discocyte, echinocyte I, echinocyte II, echinocyte III and sphero-echinocyte morphologies during 42 days of in-vitro storage at 4 °C in saline-adenine-glucose-mannitol (SAGM). Computer simulations were performed to investigate the influence of storage lesion-induced membrane structural defects on cell deformability and its recoverability during optical tweezers stretching deformations. The predicted morphology and deformability indicate decreasing quality and viability of stored RBCs undergoing storage lesion. The loss of membrane structural integrity due to the storage lesion further degrades the cell deformability and recoverability during mechanical deformations. This numerical approach provides a potential framework to study the RBC deformation characteristics under varying pathophysiological conditions for better diagnostics and treatments.

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Section: Introductionmentioning

confidence: 99%

Modelling of Red Blood Cell Morphological and Deformability Changes during In-Vitro Storage

et al. 2020

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“…Nevertheless, this still should be confirmed by using other constitutive laws in three‐dimensions. In the present simulations, the red cell membrane thickness is also increased to 100 n m , which is well beyond the maximum red cell membrane thickness in the literature, in order to increase the membrane bending stiffness (8 times) while keeping the membrane shear modulus μ s the same. Although this also doubles the membrane overall shear modulus, the simulation shows that the red cell membrane buckling still persists.…”

Section: Numerical Resultsmentioning

confidence: 95%

“…The diameter of the RBC is D = 7.8 μ m . In the literature, the red cell membrane thickness values are in the range of 10 − 18 n m . However, numerically, it is not possible to reach an adequate mesh resolution to resolve the red cell membrane because of the bad condition number of solid shell elements with high‐aspect ratio in three‐dimensions .…”

Section: Numerical Resultsmentioning

confidence: 99%

“…Nodargi et al presented an isogeometric analysis formulation for simulating RBC electrodeformation. More recently, Ademiloye et al proposed a multiscale Cauchy‐Born meshfree method for nonlinear analysis of finite deformation of RBC. We refer to the review articles by Liu et al, Freund, and Jua et al regarding the further details of the numerical algorithms.…”

Section: Introductionmentioning

confidence: 99%

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A monolithic fluid‐structure interaction framework applied to red blood cells

Cetin

Şahin

2018

Numer Methods Biomed Eng

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A parallel fully coupled (monolithic) fluid-structure interaction (FSI) algorithm has been applied to the deformation of red blood cells (RBCs) in capillaries, where cell deformability has significant effects on blood rheology. In the present FSI algorithm, fluid domain is discretized using the side-centered unstructured finite volume method based on the Arbitrary Lagrangian-Eulerian (ALE) formulation; meanwhile, solid domain is discretized with the classical Galerkin finite element formulation for the Saint Venant-Kirchhoff material in a Lagrangian frame. In addition, the compatible kinematic boundary condition is enforced at the fluid-solid interface in order to conserve the mass of cytoplasmic fluid within the red cell at machine precision. In order to solve the resulting large-scale algebraic linear systems in a fully coupled manner, a new matrix factorization is introduced similar to that of the projection method, and the parallel algebraic multigrid solver BoomerAMG is used for the scaled discrete Laplacian provided by the HYPRE library, which we access through the PETSc library. Three important physical parameters for the blood flow are simulated and analyzed: (1) the effect of capillary diameter, (2) the effect of red cell membrane thickness, and(3) the effect of red cell spacing (hematocrit). The numerical calculations initially indicate a shape deformation in which biconcave discoid shape changes to a parachute-like shape. Furthermore, the parachute-like cell shape in small capillaries undergoes a cupcake-shaped buckling instability, which has not been observed in the literature. The instability forms thin riblike features, and the red cell deformation is not axisymmetric but three-dimensional. KEYWORDS buckling instability, compatible interface condition, fluid-structure interaction, monolithic approach, red blood cell deformation Int J Numer Meth Biomed Engng. 2019;35:e3171.wileyonlinelibrary.com/journal/cnm

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“…A 3D multiscale Cauchy-Born meshfree model was proposed by Ademiloye and co-workers [281,282] as an improvement to the 2D QC model employed in [279,280,283] for numerical modeling of the deformability of RBC membrane parasitized by Plasmodium falciparum. This methodology and its semi-analytical variant has been employed to examined the large deformation behavior [284,285] of healthy RBC membrane, biomechanical properties of malaria-infected RBC membrane [286] as well as the effects of thermal treatments on healthy RBC membrane deformability [287] and its biomechanical responses under various loading conditions [288,289].…”

Section: Cell Mechanicsmentioning

confidence: 99%

Meshfree and Particle Methods in Biomechanics: Prospects and Challenges

Zhang

Ademiloye

Liew

2018

Arch Computat Methods Eng

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The use of meshfree and particle methods in the field of bioengineering and biomechanics has significantly increased. This may be attributed to their unique abilities to overcome most of the inherent limitations of mesh-based methods in dealing with problems involving large deformation and complex geometry that are common in bioengineering and computational biomechanics in particular. This review article is intended to identify, highlight and summarize research works on topics that are of substantial interest in the field of computational biomechanics in which meshfree or particle methods have been employed for analysis, simulation or/and modeling of biological systems such as soft matters, cells, biological soft and hard tissues and organs. We also anticipate that this review will serve as a useful resource and guide to researchers who intend to extend their work into these research areas. This review article includes 333 references. Highlights  We present an up to date review of meshfree and particle methods, including their advantages and limitations.  We comprehensively discuss past and recent applications of meshfree and particle methods in bioengineering and biomechanics.  We identify research areas, directions, and opportunities for the application of meshfree and particle methods in bioengineering and biomechanics.

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A multiscale framework for large deformation modeling of RBC membranes

Cited by 18 publications

References 55 publications

Modelling of Red Blood Cell Morphological and Deformability Changes during In-Vitro Storage

Modelling of Red Blood Cell Morphological and Deformability Changes during In-Vitro Storage

A monolithic fluid‐structure interaction framework applied to red blood cells

Meshfree and Particle Methods in Biomechanics: Prospects and Challenges

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