2021
DOI: 10.1101/2021.08.22.457032
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A multiscale spatiotemporal model including a switch from aerobic to anaerobic metabolism reproduces succession in the early infant gut microbiota

Abstract: The human intestinal microbiome starts to form immediately after birth, and can greatly influence the health of the infant. During the first days facultative anaerobic species generally dominate, followed by a dominance of strictly anaerobic species, particularly Bifidobacterium species. An early transition to Bifidobacterium is associated with health benefits. To study the mechanisms of this transition and its hypothesised relation to oxygen, we introduce a multiscale mathematical model that considers meta… Show more

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Cited by 1 publication
(9 citation statements)
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References 115 publications
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“…We implemented the model in C++11. We based the model on our own earlier models of the gut microbiota [75,78]. Random numbers are generated with Knuth's subtractive random number generator algorithm.…”
Section: Methodsmentioning
confidence: 99%
See 4 more Smart Citations
“…We implemented the model in C++11. We based the model on our own earlier models of the gut microbiota [75,78]. Random numbers are generated with Knuth's subtractive random number generator algorithm.…”
Section: Methodsmentioning
confidence: 99%
“…We used a spatially explicit model to represent the newborn infant gut microbiota. The model is based on our earlier models of a general microbiota [75] and the infant microbiota [78]. Prebiotic digestion is the most important addition in the present version of the model.…”
Section: Methodsmentioning
confidence: 99%
See 3 more Smart Citations