1988
DOI: 10.1093/oxfordjournals.aje.a115039
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A Multistage Approach to the Cohort Analysis of Lifetime Lung Cancer Risk Among Steelworkers Exposed to Coke Oven Emissions

Abstract: A cohort analysis was performed to predict the lifetime lung cancer risk to a US or Canadian nonwhite male steelworker exposed to coke oven emissions. The procedure employed required that the lung cancer mortality (used for risk assessment) be estimated by addition of the excess to the background rates. The age-specific excess rates were obtained following selection of the proper excess risk function as implied by the multistage theory of carcinogenesis. A quantitative approach based on model fitting was used … Show more

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Cited by 28 publications
(10 citation statements)
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“…Os motores a diesel também os produzem. O risco relativo para câncer de pulmão é 15 vezes maior para as pessoas expostas aos hidrocarbonetos aromáticos policíclicos do que para as não expostas (49,50) .…”
Section: Vii) Hidrocarbonetos Aromáticos Policíclicosunclassified
“…Os motores a diesel também os produzem. O risco relativo para câncer de pulmão é 15 vezes maior para as pessoas expostas aos hidrocarbonetos aromáticos policíclicos do que para as não expostas (49,50) .…”
Section: Vii) Hidrocarbonetos Aromáticos Policíclicosunclassified
“…The remaining lifetime risks presented in Table IV, ranging from 1 to 14 deaths per 1,000 lifetime workers, are all comparable to lifetime risk estimates for cancer-causing occupational exposures such as formaldehyde [Siegel et al, 1983], diesel exhausts [Smith and Stayner, 1990], silica [Nurminen et al, 1992], galactic radiation [Friedberg et al, 1989], and coke oven emissions [Dong et al, 1988]. This suggests that specific injury events are as great a fatal hazard to certain occupations as cancer-causing exposures are for others.…”
Section: Cause-specific Lifetime Risksmentioning
confidence: 57%
“…These studies range from estimating the elevated numbers of deaths from certain illnesses or injuries for specific workers (e.g., proportionate mortality studies, standardized mortality studies) [Robinson et al, 1995;Singleton and Beaumont, 1989;Commonwealth of Pennsylvania, 1987;Mace, 1986;Milham, 1983] to estimating a worker's lifetime risk of dying of a stated illness based on exposure to a hazard in a specific job [Palmer and Rickett, 1992;Nurminen et al, 1992;Stayner et al, 1992;Smith and Stayner, 1990;Hodgson and Jones, 1990;Friedberg et al, 1989;Dong et al, 1988;NIOSH, 1987;Purchase et al, 1987;Siegel et al, 1983]. These studies range from estimating the elevated numbers of deaths from certain illnesses or injuries for specific workers (e.g., proportionate mortality studies, standardized mortality studies) [Robinson et al, 1995;Singleton and Beaumont, 1989;Commonwealth of Pennsylvania, 1987;Mace, 1986;Milham, 1983] to estimating a worker's lifetime risk of dying of a stated illness based on exposure to a hazard in a specific job [Palmer and Rickett, 1992;Nurminen et al, 1992;Stayner et al, 1992;Smith and Stayner, 1990;Hodgson and Jones, 1990;Friedberg et al, 1989;Dong et al, 1988;NIOSH, 1987;Purchase et al, 1987;Siegel et al, 1983].…”
Section: Introductionmentioning
confidence: 99%
“…Recent literature on epidemiologic studies ofhuman cancer indicates that the Armitage-Doll multistage model of carcinogenesis can be used to examine the relationships of excess cancer mortality to some carcinogenic exposure and time-related variables such as age at initial exposure; duration of exposure; and time since exposure terminated (1)(2)(3)(4). These relationships help to predict benefits of different strategies for reducing carcinogenic exposure in the workplace or environment.…”
Section: Introductionmentioning
confidence: 99%