A multistrain probiotic improves handgrip strength and functional capacity in patients with COPD: A randomized controlled trial

Karim, Asima; Muhammad, Tahir; Iqbal, Meesha; Qaisar, Rizwan

doi:10.1016/j.archger.2022.104721

Cited by 44 publications

(26 citation statements)

References 37 publications

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“…The general characteristics of the included studies are outlined in Table S4. Trials were published between 1996 and 2023, and were carried out in Asia, 12,27–31,77–81,84–229 Europe, 230–262 America,…”

Section: Resultsmentioning

confidence: 99%

Beneficial effects of the probiotics and synbiotics supplementation on anthropometric indices and body composition in adults: A systematic review and meta‐analysis

Saadati,

Naseri,

Asbaghi

et al. 2023

Obesity Reviews

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SummaryStudies have suggested that probiotics and synbiotics can improve body weight and composition. However, randomized controlled trials (RCTs) demonstrated mixed results. Hence, we performed a systematic review and meta‐analysis to evaluate the effectiveness of probiotics and synbiotics on body weight and composition in adults. We searched PubMed/Medline, Ovid/Medline, Scopus, ISI Web of Science, and Cochrane library up to April 2023 using related keywords. We included all RCTs investigating the effectiveness of probiotics and/or synbiotics supplementation on anthropometric indices and body composition among adults. Random‐effects models were applied for performing meta‐analyses. In addition, we conducted subgroup analyses and meta‐regression to explore the non‐linear and linear relationship between the length of follow‐up and the changes in each outcome. We included a total of 200 trials with 12,603 participants in the present meta‐analysis. Probiotics or synbiotics intake led to a significant decrease in body weight (weighted mean difference [WMD]: −0.91 kg; 95% CI: −1.08, −0.75; p < 0.001), body mass index (BMI) (WMD: −0.28 kg/m2; 95% CI: −0.36, −0.21; p < 0.001), waist circumference (WC) (WMD: −1.14 cm; 95% CI: −1.42, −0.87; p < 0.001), waist‐to‐hip ratio (WHR) (WMD: −0.01; 95% CI: −0.01, −0.00; p < 0.001), fat mass (FM) (WMD: −0.92 kg; 95% CI: −1.05, −0.79; p < 0.001), and percentage of body fat (%BF) (WMD: −0.68%; 95% CI: −0.94, −0.42; p < 0.001) compared to controls. There was no difference in fat‐free mass (FFM) and lean body mass (LBM). Subgroup analyses indicated that probiotics or synbiotics administered as food or supplement resulted in significant changes in anthropometric indices and body composition. However, compared to controls, FM and %BF values were only reduced after probiotic consumption. Our results showed that probiotics or synbiotics have beneficial effects on body weight, central obesity, and body composition in adults and could be useful as an add on to weight loss products and medications.

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Section: Resultsmentioning

confidence: 99%

Beneficial effects of the probiotics and synbiotics supplementation on anthropometric indices and body composition in adults: A systematic review and meta‐analysis

Saadati,

Naseri,

Asbaghi

et al. 2023

Obesity Reviews

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“…[18,20] Moreover, supplementing probiotic preparations can accelerate the proliferation of intestinal epithelial cells, downregulate intestinal mucosal permeability, inhibit the production of intestinal-derived endotoxins, promote the digestion and absorption of nutrients by individuals, and protect the intestinal mucosa, so as to achieves the therapeutic goals. [18][19][20] A double-sided, randomized controlled study by Karim A et al [21] on 104 patients with COPD from 2 tertiary hospitals receiving placebo treatment or probiotic treatment showed that the probiotic group had significantly improved exercise ability, and the levels of inflammatory factors such as C-reactive protein in the body were significantly reduced. [21] It has been confirmed that the auxiliary intervention of probiotics based on symptomatic treatment of COPD can improve the muscle function, strength, and body function of COPD patients by stabilizing neuromuscular and regulating intestinal permeability.…”

Section: Discussionmentioning

confidence: 99%

Probiotics combined with Budesonide and Ipratropium bromide for chronic obstructive pulmonary disease: A retrospective analysis

Chen,

Wu,

Wang

et al. 2024

Medicine

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To explore the effect of probiotics combined with budesonide and ipratropium bromide in the treatment of chronic obstructive pulmonary disease (COPD) on lung function and gut microbiota. This was a retrospective study of prospectively collected clinical data of 118 patients with COPD admitted to our hospital between January 2020 and December 2022. According to the treatment records, 59 patients received budesonide and irpratropium bromide (control group), and 59 patients received probiotics combined with budesonide and irpratropium bromide (observation group). The lung function, inflammatory factor levels, airway remodeling, and gut microbiota before and after treatment were compared between the 2 groups. After treatment, FVC, MMEF, PEF, and FEV1 in the 2 groups were higher than before treatment, and the values in the observation group were higher than those in the control group (P < .05). After treatment, the serum levels of TNF-α, IL-6, and PCT in the 2 groups were lower than before treatment, and the levels in the observation group were lower than those in the control group (P < .05). After treatment, the levels of serum MMP-9, VEGF, basic fibroblast growth factor, and NGF in the 2 groups were lower than before treatment, and the levels in the observation group were lower than those in the control group (P < .05). After treatment, the levels of lactobacilli and bifidobacteria in the 2 groups increased compared to those before treatment, and the observation group had a higher level, while the levels of Enterobacteriaceae and Enterococcus were lower in the observation group than those before treatment (P < .05). Based on budesonide and irpratropium bromide, probiotic treatment of COPD is more conducive to reducing the degree of inflammatory reactions, inhibiting airway remodeling, regulating the level of gut microbiota, and promoting the recovery of lung function.

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“…Supplementation of F. prausnitzii in a high‐fat fed rodent model found the treatment to increase muscle mass, adiponectin signaling, and fatty acid oxidation, possibly through increased mitochondrial capacity 56 . Although the relationships between gut microbiota composition and muscle strength are not fully understood, hand‐grip strength has been shown to improve in the elderly following both inulin/fructooligosaccharide prebiotic 57 and multistrain probiotic supplementation 58 . In these studies, hand‐grip strength improvements were mediated in part by reductions in gut leakage, systemic oxidative stress, and chronic inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…56 Although the relationships between gut microbiota composition and muscle strength are not fully understood, hand-grip strength has been shown to improve in the elderly following both inulin/fructooligosaccharide prebiotic 57 and multistrain probiotic supplementation. 58 In these studies, hand-grip strength improvements were mediated in part by reductions in gut leakage, systemic oxidative stress, and chronic inflammation. Taken together, these results highlight the need for future work examining the role of muscle strength on the gut microbiome-muscle axis.…”

Section: Positive Correlation Negative Correlationmentioning

confidence: 99%

Physical activity‐induced alterations of the gut microbiota are BMI dependent

Shah

Moossavi

et al. 2023

The FASEB Journal

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Physical inactivity is one of the leading causes of chronic metabolic disease including obesity. Increasing physical activity (PA) has been shown to improve cardiometabolic and musculoskeletal health and to be associated with a distinct gut microbiota composition in trained athletes. However, the impact of PA on the gut microbiota is inconclusive for individuals performing PA in their day‐to‐day life. This study examined the role of PA and hand‐grip strength on gut microbiome composition in middle‐aged adults (40–65 years, n = 350) with normal (18.5–24.9 kg/m2) and overweight (25–29.9 kg/m2) body mass index (BMI). PA was recorded using the International Physical Activity Questionnaire, and hand‐grip strength was measured using a dynamometer. Serum samples were assessed for lipidomics while DNA was extracted from fecal samples for microbiome analysis. Overweight participants showed a higher concentration of triacylglycerols, and lower concentrations of cholesteryl esters, sphingomyelin, and lyso‐phosphotidylcholine lipids (p < .05) compared with those with normal BMI. Additionally, overweight participants had a lower abundance of the Oscillibacter genus (p < .05). The impact of PA duration on the gut microbiome was BMI dependent. In normal but not overweight participants, high PA duration showed greater relative abundance of commensal taxa such as Actinobacteria and Proteobacteria phyla, as well as Collinsella and Prevotella genera (p < .05). Furthermore, in males with normal BMI, a stronger grip strength was associated with a higher relative abundance of Faecalibacterium and F. prausnitzii (p < .05) compared with lower grip strength. Taken together, data suggest that BMI plays a significant role in modeling PA‐induced changes in gut microbiota.

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A multistrain probiotic improves handgrip strength and functional capacity in patients with COPD: A randomized controlled trial

Cited by 44 publications

References 37 publications

Beneficial effects of the probiotics and synbiotics supplementation on anthropometric indices and body composition in adults: A systematic review and meta‐analysis

Beneficial effects of the probiotics and synbiotics supplementation on anthropometric indices and body composition in adults: A systematic review and meta‐analysis

Probiotics combined with Budesonide and Ipratropium bromide for chronic obstructive pulmonary disease: A retrospective analysis

Physical activity‐induced alterations of the gut microbiota are BMI dependent

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