A murine model of hypertensive heart disease in older women
Audrey Morin-Grandmont,
Elisabeth Walsh-Wilkinson,
Sara-Ève Thibodeau
et al.
Abstract:We propose a new mouse (C57Bl6/J) model combining several features of heart failure with preserved ejection fraction encountered in older women, including hypertension from Angiotensin II infusion (AngII), menopause, and advanced age. To mimic menopause, we delayed ovariectomy (Ovx) at 12 months of age. We also studied the effects of AngII infusion for 28 days in younger animals and the impact of losing gonadal steroids earlier in life. We observed that AngII effects on heart morphology were different in young… Show more
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