A Mussel‐Inspired Conductive, Self‐Adhesive, and Self‐Healable Tough Hydrogel as Cell Stimulators and Implantable Bioelectronics

Han, Lu; Li, Xiong; Wang, Menghao; Gan, Donglin; Deng, Weili; Wang, Kefeng; Fang, Liming; Liu, Kezhi; Chan, C.W.; Tang, Youhong; Weng, Lu‐Tao; Yuan, Huipin

doi:10.1002/smll.201601916

Cited by 605 publications

(414 citation statements)

References 42 publications

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“…Fourth passage cells, which exhibited stable growth and retained their primary characteristics, were used for subsequent experiments. Cell culture procedures were performed as described in our previous study . Cell proliferation was evaluated via the Alamar Blue assay.…”

Section: Methodsmentioning

confidence: 99%

“…Six healthy rabbits of either gender (3 kg) were selected randomly to implant the samples for 12 weeks. The surgical procedure was performed under general sterile conditions following the methods described in our previous study . Briefly, the rabbits were anesthetized via ear vein injections of pelltobarbitalum natricum (30 to 35 mg/kg) prior to surgery.…”

Section: Methodsmentioning

confidence: 99%

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Chitosan/biphasic calcium phosphate scaffolds functionalized with BMP‐2‐encapsulated nanoparticles and RGD for bone regeneration

Gan

Liu

et al. 2018

J Biomedical Materials Res

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Advancements in bone tissue engineering require the improvement of tissue scaffolds, which should not only exhibit suitable mechanical properties and highly porous structures, but also effectively carry signaling molecules that can mediate bone formation and tissue regeneration. In the present study, we established chitosan/biphasic calcium phosphate (CS/BCP) scaffolds functionalized with Arg-Gly-Asp (RGD) and BMP-2-loaded nanoparticles. The resulting scaffolds were highly similar to natural bone extracellular matrix (ECM) in terms of composition and structural properties. First, we synthesized CS/BCP composite bionic scaffolds via the freeze-drying method. Then, RGD peptides were covalently conjugated onto the scaffolds via the EDC/NHS method. The BMP-2-encapsulated BSA nanoparticles were prepared via a desolvation method and then coated with CS and oxidized alginate to achieve sustained release of BMP-2. In vitro cell culture and in vivo implantation tests confirmed that RGD and BMP-2 synergistically enhanced cell attachment and spreading by providing integrin binding surface and facilitating osteogenic differentiation. In summary, the bioceramic/biopolymer scaffolds functionalized with signaling biomolecules successfully provided a favorable microenvironment for bone formation and thus serve as potential candidates for use in bone tissue engineering. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2613-2624, 2018.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Chitosan/biphasic calcium phosphate scaffolds functionalized with BMP‐2‐encapsulated nanoparticles and RGD for bone regeneration

Gan

Liu

et al. 2018

J Biomedical Materials Res

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“…Hydrogels, especially those with excellent mechanical performance, have attracted extensive attention, giving rise to their promising application as structural biomaterials, implantable devices, actuators, and more . To form a tough hydrogel, a number of energy‐dissipating segments should be dispersed inside of the hydrogel network to serve as irreversible and reversible sacrificial bonds .…”

Section: Methodsmentioning

confidence: 99%

One‐Step Preparation of Tough and Self‐Healing Polyion Complex Hydrogels with Tunable Swelling Behaviors

Tang

Yang

et al. 2018

Macromol. Rapid Commun.

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Polyion complex (PIC) hydrogels formed by charge attraction of opposite charged polymers have received unique research interest. Their conventional preparation method, with a large amount of residual salt after polymerization, requires a long‐term dialysis treatment to remove the salt and toughen the gel. Here, a promising strategy for the one‐step preparation of tough PIC hydrogels without dialysis after polymerization is provided. Bicarbonate and proton ions are selected as the counter ions of the cationic monomer and anionic polymers, respectively. By a CO2‐generating reaction between the counter ions, the residual salt is removed before polymerization, and thus, a PIC hydrogel with tough mechanical performance can be obtained instantly without dialysis. Due to the absence of dialysis, the tough hydrogel can be formed with a wide range of ratios for the oppositely charged polymer with distinct swelling behaviors from non‐swelling to super‐swelling. This tunable swelling behavior shows the possibility for shape‐morphing systems from this one‐step method.

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“…[1][2][3] As enviro-sensitive materials, hydrogels have been widely used for industrial and biomedical applications due to their unique structure and capabilities. [4][5][6] The properties of a specific hydrogel are extremely important in selecting which materials are suitable for a given application. The suitability of a hydrogel for a given application depends on the mechanical properties that are affected by the environmental conditions such as temperature, pH level and ionic strength, magnetic and electric fields as well as the monomer type and crosslinking agents.…”

Section: Introductionmentioning

confidence: 99%

In situ polymerized hyperbranched polymer reinforced poly(acrylic acid) hydrogels

Dehbari

Tavakoli

Khatrao

et al. 2017

Mater. Chem. Front.

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a Hydrogels have been extensively investigated for use in various applications. Poly acrylic acid (PAA) is a common example, which has been widely used due to its super hydrophilicity properties, biocompatibility and biodegradability characteristics. However its poor mechanical properties, which have been addressed in many research studies, are known as a drawback that limits its applications. So, enhancing PAA mechanical properties using a hyperbranched polymer (HB) is the key question to be addressed in this research.Investigations of the mechanical properties of the PAA-HB hydrogel revealed 130% improvement in the ultimate tensile strength, indicating a two times enhancement compared to that of PAA. Statistical analysis showed that the overall effect of introducing notches (with different depths) on the selected mechanical properties of both PAA and PAA-HB was significant. Mechanical characterization of PAA-HB networks showed that significant improvement in the mechanical properties was achieved as the capability of water uptake increased by 20%. Characterization of the physical properties confirmed that participation of HB may form a PAA based hybrid material with good swelling properties. Those findings are attributed to the supramolecular structure of the HB, which can introduce physical entanglement between the PAA network structure and increase the crystallinity of the final hydrogel as compared to those from the PAA hydrogel.

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A Mussel‐Inspired Conductive, Self‐Adhesive, and Self‐Healable Tough Hydrogel as Cell Stimulators and Implantable Bioelectronics

Cited by 605 publications

References 42 publications

Chitosan/biphasic calcium phosphate scaffolds functionalized with BMP‐2‐encapsulated nanoparticles and RGD for bone regeneration

Chitosan/biphasic calcium phosphate scaffolds functionalized with BMP‐2‐encapsulated nanoparticles and RGD for bone regeneration

One‐Step Preparation of Tough and Self‐Healing Polyion Complex Hydrogels with Tunable Swelling Behaviors

In situ polymerized hyperbranched polymer reinforced poly(acrylic acid) hydrogels

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