A nano approach towards the creation of a biointerface as stimulator of osteogenic differentiation

Fanaee, Sajjad; Labbaf, Sheyda; Karamali, Fereshteh; Esfahani, Mohammad-Hossein Nasr

doi:10.1016/j.msec.2020.111746

Cited by 5 publications

(1 citation statement)

References 55 publications

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“…As shown in Figure 3J , the cumulative release profile showed that the initial burst of OGP release occurred within 24 h, accounting for approximately 18% of the overall amount. The initial abrupt release was able to effectively stimulate cell proliferation and differentiation in the bone defect area ( Fanaee et al, 2021 ). OGP protein release was observed for up to 14 days, which is due to the synergistic effect of physical encapsulation and chemical interlocking of the dual network hydrogel to ensure sustained drug release.…”

Section: Resultsmentioning

confidence: 99%

Sustained delivery of osteogenic growth peptide through injectable photoinitiated composite hydrogel for osteogenesis

Liu

Sun

et al. 2023

Front. Bioeng. Biotechnol.

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One of the most challenging clinical issues continues to be the effective bone regeneration and rebuilding following bone abnormalities. Although osteogenic growth peptide (OGP) has been proven to be effective in promoting osteoblast activity, its clinical application is constrained by abrupt release and easily degradation. We developed a GelMA/HAMA dual network hydrogel loaded with OGP based on a combination of physical chain entanglement and chemical cross-linking effects to produce an efficient long-term sustained release of OGP. The hydrogel polymers were quickly molded under ultraviolet (UV) light and had the suitable physical characteristics, porosity structure and biocompatibility. Significantly, the GelMA/HAMA-OGP hydrogel could promote cell proliferation, adhesion, increase osteogenic-related gene and protein expression in vitro. In conclusion, the OGP sustained-release system based on GelMA/HAMA dual network hydrogel offers a fresh perspective on bone regeneration therapy.

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Section: Resultsmentioning

confidence: 99%