A nano-composite hyaluronic acid-based hydrogel efficiently antibacterial and scavenges ROS for promoting infected diabetic wound healing

Zhai, Xinrang; Hu, Honghua; Hu, Miner; Ji, Shunxian; Lei, Tao; Wang, Xiaozhao; Zhu, Zhiqiang; Dong, Wei; Teng, Chong; Wei, Wei

doi:10.1016/j.carbpol.2024.122064

Cited by 20 publications

(2 citation statements)

References 47 publications

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“…The proposed structure and mechanism for the formation of SA-g-poly(acrylic acid) is shown in Figure 1. A similar mechanism has been proposed for hydrogels based on other polysaccharides [21,41]. The reaction to produce the hydrogel materials was conducted under controlled conditions in an inert gas atmosphere.…”

Section: Resultsmentioning

confidence: 85%

“…The synthesis of new hydrogel structures based on synthetic polymers and polysaccharides has been the subject of numerous studies. The most commonly used polysaccharides include chitosan [10,11], alginate [9,[12][13][14], starch [15][16][17], cellulose [18], carboxymethylcellulose [19,20], hyaluronic acid [21], etc. These biopolymers have several desirable features, such as being abundant, inexpensive, renewable, biodegradable, polyfunctional, highly reactive chemically, and possessing a wide variety of properties as well as adsorption capacities [15,22,23].…”

Section: Introductionmentioning

confidence: 99%

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Structure Effects on Swelling Properties of Hydrogels Based on Sodium Alginate and Acrylic Polymers

Kowalski,

Witczak,

Kuterasiński

2024

Molecules

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Hydrogels based on sodium alginate (SA) and partially neutralised poly(acrylic acid) were obtained by radical polymerisation. The hydrogels were cross-linked with N,N′-methylenebisacrylamide (MBA), simultaneously grafting the resulting polymer onto SA. The findings of the FTIR spectroscopy showed that all of the hydrogels were effectively synthesized and sodium alginate was chemically bonded with the poly(sodium acrylate) matrix. DSC analysis of the melting heat and glass transition parameters indicated that the hydrogel structure had changed as a result of the cross-linking process. Sodium alginate and MBA were tested at different concentrations to determine how they affected the hydrogel properties. A very high content of the biopolymer, i.e., sodium alginate, was used in our research, up to 33 wt%. This resulted in durable and stable hydrogels with a very high ability to uptake water, comparable to hydrogels based on synthetic polymers only. The ability to swell is inversely proportional to the quantity of MBA present. By increasing the amount of sodium alginate in the hydrogel, the ability of the hydrogel to absorb water is reduced. However, water uptake remains relatively high at 350 g·g−1, even for the hydrogel with the highest SA content.

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Section: Resultsmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Structure Effects on Swelling Properties of Hydrogels Based on Sodium Alginate and Acrylic Polymers

Kowalski,

Witczak,

Kuterasiński

2024

Molecules

View full text Add to dashboard Cite

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Naturally Inspired Tree‐Ring Structured Dressing Provides Sustained Wound Tightening and Accelerates Closure

Chen,

Zhang,

Zhang

et al. 2024

Advanced Materials

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Mechanically regulated wound dressings require a rational combination of contraction and adhesion functions as well as balancing exudate‐induced swelling issues. However, many of the reported dressings face the dilemma of impaired function and impeded wound self‐contraction due to fluid‐absorbing swelling. In this study, inspired by the tree ring, a core–ring structured hydrogel dressing capable of mechanical modulation is designed, and prepare it using a simple two‐step photopolymerization process. The core covers the center of the wound, contracts spontaneously at body temperature to generate a contractile force of 3.4 kPa, and resists swelling. Meanwhile, the ring adheres to the normal epidermis around the wound and transfers the contraction stress to the wound edge. The integration of a functionally independent core and ring ultimately achieves effective wound traction and avoids dressing swelling. In murine and porcine skin wound‐healing models, this hydrogel with a closely connected core and ring promotes healing by accelerating epidermal closure (50% closure in mouse skin on day 2, 85% closure in pig skin on day 8), collagen deposition, vascular maturation, and extracellular matrix remodeling. These results can guide further research on mechanical force modulation in wound healing, with the potential for clinical translation.

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Investigating the Antibacterial Effectiveness of Zinc Particles in Different Forms within Alginate-Based Hydrogels Incorporating Nanocellulose

Razi,

Timuda,

Khaerudini

et al. 2024

J Clust Sci

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A nano-composite hyaluronic acid-based hydrogel efficiently antibacterial and scavenges ROS for promoting infected diabetic wound healing

Cited by 20 publications

References 47 publications

Structure Effects on Swelling Properties of Hydrogels Based on Sodium Alginate and Acrylic Polymers

Structure Effects on Swelling Properties of Hydrogels Based on Sodium Alginate and Acrylic Polymers

Naturally Inspired Tree‐Ring Structured Dressing Provides Sustained Wound Tightening and Accelerates Closure

Investigating the Antibacterial Effectiveness of Zinc Particles in Different Forms within Alginate-Based Hydrogels Incorporating Nanocellulose

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