A nanodrug system overexpressed circRNA_0001805 alleviates nonalcoholic fatty liver disease via miR-106a-5p/miR-320a and ABCA1/CPT1 axis

Li, Jian; Qi, Jing; Tang, Yawen; Liu, Huaizheng; Zhou, Kefu; Dai, Zheren; Yuan, Lehong; Sun, Chuanzheng

doi:10.1186/s12951-021-01108-8

Cited by 26 publications

(15 citation statements)

References 54 publications

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“…The possibility that miR-204-5p can act on NAFLD through the inhibition of inflammatory factors still needs further exploration. MiR-106a-5p can exert an influence on NAFLD progression through the NF-κB signaling pathway (Li et al, 2021). It was found that miR-106a-5p expression was elevated in CRC tissues, and patients with high miR-106a-5p expression tended to have a poor prognosis (Yue et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

The molecular basis of the associations between non-alcoholic fatty liver disease and colorectal cancer

Qiu

Hu²,

Rao³

et al. 2022

Front. Genet.

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Background: Given the ongoing research on non-alcoholic fatty liver disease (NAFLD) and colorectal cancer (CRC), the number of studies suggesting a strong link between NAFLD and CRC is on the rise, while its underlying pathological mechanisms remain uncertain. This study aims to explore the shared genes and mechanisms and to reveal the molecular basis of the association between CRC and NAFLD through bioinformatics approaches.Methods: The Gene Expression Omnibus (GEO) dataset GSE89632 is downloaded for NAFLD cases and healthy controls. Additionally, the GSE4107 and GSE9348 datasets are obtained for CRC cases and healthy controls. Differentially expressed genes (DEGs) are obtained for NAFLD and CRC datasets, as well as shared genes between the two disorders. GO and KEGG enrichment analyses are further conducted. Subsequently, the STRING database and Cytoscape software are utilized to establish the PPI network and identify the hub genes. Then, co-expression analysis is performed using GeneMANIA. Subsequently, ROC curves and external datasets validation were applied to further screen the candidate markers. Finally, NetworkAnalyst is available as a means to construct a miRNA-gene regulatory network.Results: Under the threshold of FDR ≤ 0.01, 147 common genes are obtained in NAFLD and CRC. Categorization of GO functions shows that DEGs are predominantly enriched in “response to organic substance”, “cellular response to chemical stimulus”, and “response to external stimulus”. The predominant KEGG pathways in DEGs are the “IL-17 signaling pathway”, the “TNF signaling pathway”, “Viral protein interaction with cytokine and cytokine receptor”, “Cytokine-cytokine receptor interaction”, and the “Toll-like receptor signaling pathway”. Additionally, MYC, IL1B, FOS, CXCL8, PTGS2, MMP9, JUN, and IL6 are identified as hub genes by the evaluation of 7 algorithms. With the construction of miRNA-gene networks, 2 miRNAs, including miR-106a-5p, and miR-204-5p are predicted to be potential key miRNAs.Conclusion: This study identifies possible hub genes acting in the co-morbidity of NAFLD and CRC and discovers the interaction of miRNAs and hub genes, providing a novel understanding of the molecular basis for the relevance of CRC and NAFLD, thus contributing to the development of new therapeutic strategies to combat NAFLD and CRC.

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Section: Discussionmentioning

confidence: 99%

The molecular basis of the associations between non-alcoholic fatty liver disease and colorectal cancer

Qiu

Hu²,

Rao³

et al. 2022

Front. Genet.

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“…Consequently, it has unique properties and cytological functions in the occurrence and development of tumors. Recent data suggest that circRNAs play a role in various pathophysiologies, including B-cell activity in multiple sclerosis and fatty acid metabolism disorders in non-alcoholic fatty liver disease ( 132 , 133 ).…”

Section: Discussionmentioning

confidence: 99%

Circ_0007534 as new emerging target in cancer: Biological functions and molecular interactions

Liu

Dong²,

Chen³

et al. 2022

Front. Oncol.

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Circular RNA (circRNAs), an important member of the non-coding RNA (ncRNA) family, are widely expressed in a variety of biological cells. Owing to their stable structures, sequence conservations, and cell- or tissue-specific expressions, these RNA have become a popular subject of scientific research. With the development of sequencing methods, it has been revealed that circRNAs exert their biological function by sponging microRNAs (miRNAs), regulating transcription, or binding to proteins. Humans have historically been significantly impacted by various types of cancer. Studies have shown that circRNAs are abnormally expressed in various cancers and are involved in the occurrence and development of malignant tumors, such as tumor cell proliferation, migration, and invasion. As one of its star molecules, circ_0007534 is upregulated in colorectal, cervical, and pancreatic cancers; is closely related to the occurrence, development, and prognosis of tumors; and is expected to become a novel tumor marker and therapeutic target. This article briefly reviews the expression and mechanism of circ_0007534 in malignant tumors based on the domestic and foreign literature.

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“…These miRNAs separately suppress ATP-binding cassette transporter A1 (ABCA1) and carnitine palmitoyl transferase 1 (CPT1), collaboratively inhibiting inflammation and the accumulation of lipids, thus ameliorating NAFLD. 303 In addition, circ_0057558 is upregulated in NAFLD models, and the study revealed that circ_0057558 sequesters miR-206, which restores the Rho-associated kinase 1 (ROCK1)-AMPK signalling pathway and stimulated lipogenesis and TG secretion, thereby exacerbating NAFLD. 304 Besides, by sponging miR-188-3p, circ_0048179 increases GPX4 levels and decelerates lipid accumulation.…”

Section: The Role Of Mirnas In Metabolic Diseasementioning

confidence: 99%

“…NAFLD: Lipid metabolism can also be influenced by circRNAs. Li et al 303 constructed a nanodrug system to upregulate cir-cRNA_0001805 in hepatocytes, which contributed to treating NAFLD by sponging miR-106a-5p and miR-320a. These miRNAs separately suppress ATP-binding cassette transporter A1 (ABCA1) and carnitine palmitoyl transferase 1 (CPT1), collaboratively inhibiting inflammation and the accumulation of lipids, thus ameliorating NAFLD.…”

Section: The Role Of Mirnas In Metabolic Diseasementioning

confidence: 99%

Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study

Lin

et al. 2023

Sig Transduct Target Ther

129

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Epigenetics regulates gene expression and has been confirmed to play a critical role in a variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease (NAFLD), osteoporosis, gout, hyperthyroidism, hypothyroidism and others. The term ‘epigenetics’ was firstly proposed in 1942 and with the development of technologies, the exploration of epigenetics has made great progresses. There are four main epigenetic mechanisms, including DNA methylation, histone modification, chromatin remodelling, and noncoding RNA (ncRNA), which exert different effects on metabolic diseases. Genetic and non-genetic factors, including ageing, diet, and exercise, interact with epigenetics and jointly affect the formation of a phenotype. Understanding epigenetics could be applied to diagnosing and treating metabolic diseases in the clinic, including epigenetic biomarkers, epigenetic drugs, and epigenetic editing. In this review, we introduce the brief history of epigenetics as well as the milestone events since the proposal of the term ‘epigenetics’. Moreover, we summarise the research methods of epigenetics and introduce four main general mechanisms of epigenetic modulation. Furthermore, we summarise epigenetic mechanisms in metabolic diseases and introduce the interaction between epigenetics and genetic or non-genetic factors. Finally, we introduce the clinical trials and applications of epigenetics in metabolic diseases.

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A nanodrug system overexpressed circRNA_0001805 alleviates nonalcoholic fatty liver disease via miR-106a-5p/miR-320a and ABCA1/CPT1 axis

Cited by 26 publications

References 54 publications

The molecular basis of the associations between non-alcoholic fatty liver disease and colorectal cancer

The molecular basis of the associations between non-alcoholic fatty liver disease and colorectal cancer

Circ_0007534 as new emerging target in cancer: Biological functions and molecular interactions

Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study

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