A Nanographene‐Porphyrin Hybrid for Near‐Infrared‐Ii Phototheranostics

Zhao, Hao; Wang, Yu; Chen, Qiang; Liu, Ying; Gao, Yijian; Müllen, Klaus; Li, Shengliang; Narita, Akimitsu

doi:10.1002/advs.202309131

Cited by 10 publications

(1 citation statement)

References 78 publications

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“…Light offers the advantages of noninvasiveness, high resolution, and controllable timing. Concurrently, photothermal therapy is gaining increasing popularity in the realm of antimicrobial treatment. ,− The photothermal material is delivered to the wound in the form of a microneedle for enhanced efficacy and optimization of its photothermal properties.…”

Section: Microneedle Design Strategymentioning

confidence: 99%

Design Strategy of Microneedle Systems for Skin Wound Healing: Based on the Structure of Tips and Therapeutic Methodologies

Ji,

Li,

et al. 2024

ACS Appl. Bio Mater.

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The skin, being the largest organ of the human body, is susceptible to damage resulting in wounds that are vulnerable to pathogenic attacks and fail to provide effective protection for internal tissues. Therefore, it is crucial to expedite wound healing. In recent years, microneedles have garnered significant attention as an innovative drug delivery system owing to their noninvasive and painless administration, simplified application process, precise control over drug release, and versatile loading capabilities. Consequently, they hold immense potential for the treatment of skin wound. This review presents a comprehensive design strategy for the microneedle system in promoting skin wound healing. First, the process of skin wound healing and the characteristics of specific wounds are elucidated. The design strategies for microneedles are subsequently presented and classified based on their structural and therapeutic methodologies. Finally, a succinct recapitulation of the previously discussed points and a prospective analysis are provided.

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Section: Microneedle Design Strategymentioning

confidence: 99%

Design Strategy of Microneedle Systems for Skin Wound Healing: Based on the Structure of Tips and Therapeutic Methodologies

Ji,

Li,

et al. 2024

ACS Appl. Bio Mater.

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A NIR‐II‐Emissive Organic Nanomedicine with Biomimetic Engineering for High‐Contrast Targeted Bioimaging and Multiple Phototherapies of Pancreatic Tumors

Wang,

Zhang,

Wang

et al. 2024

Adv Funct Materials

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Recent advances are achieved in the design and development of efficient organic photosensitizers (PSs), especially with fluorescence imaging navigation in the second near‐infrared (NIR‐II, 1000–1700 nm) region. However, there are simply a handful of NIR‐II emissive organic PSs with efficient oxygen‐independent capability due to the scarcity of high‐performance NIR‐responsive organic materials and targeted delivery. Herein, a NIR‐II‐emissive organic nanomedicine with biomimetic engineering for high‐performance NIR‐II imaging and targeted multiple phototherapies of pancreatic tumors is reported. An A‐D‐A‐type conjugated small‐molecule TPC is designed and used to prepare water‐dispersive nanoparticles, which demonstrated high efficiency for type I and type II photodynamic performances, good photothermal conversion of 57%, and bright NIR‐II emission with a quantum yield of 9.8% under 808 nm light irradiation. With pancreatic cancer cell membrane camouflage, the biomimetic TPC nanomedicine achieved high‐resolution and targeted bioimaging of whole‐body blood vessels and tumors. Antitumor experiments demonstrated the high efficiency of the biomimetic TPC nanomedicine for pancreatic tumor elimination and good biosafety with 808 nm light irradiation. This work demonstrated a NIR‐II‐emissive versatile nanomedicine with enhanced tumor‐targeting for high‐resolution NIR‐II bioimaging and superior phototheranostics, providing a feasible idea for the evolution of targeted and high‐performance theranostics.

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A Poly(2,7‐anthrylene) with peri‐Fused Porphyrin Edges

Gu,

Xiang,

Liang

et al. 2024

Angewandte Chemie

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Anthracene has served as an important building block of conjugated polymers with the connecting positions playing a crucial role for the electronic structures. Herein, anthracene units have been coupled through their 2,7‐carbons to develop an unprecedented, conjugated polymer, namely, poly(2,7‐anthrylene) featuring additional peri‐fused porphyrin edges. The synthesis starts from a 2,7‐dibromo‐9‐nickel(II) porphyrinyl‐anthracene as the pivotal precursor. Polymerization is achieved by an AA‐type Yamamoto coupling, followed by a polymer‐analogous oxidative cyclodehydrogenation to obtain a peri‐fusion between porphyrin and anthracene moieties. Although further cyclodehydrogenation between the repeating units cannot be achieved in solution, the thermal treatment of the precursor polymer derived from 2,7‐dibromo‐9‐porphyrinyl‐anthracene on a metal surface realizes the full cyclodehydrogenation. The difference between solution and on‐surface reactivity can be rationalized by the larger dihedral angle between repeat units in solution, which is reduced under the pronounced interaction with the metal surface. The peri‐fusion in the title polymer gives rise to a narrow electronic band gap optical absorptions extending far into the near‐infrared region. Oligomeric models are synthesized as well to support the analyses of the electronic and photophysical properties.

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A Nanographene‐Porphyrin Hybrid for Near‐Infrared‐Ii Phototheranostics

Cited by 10 publications

References 78 publications

Design Strategy of Microneedle Systems for Skin Wound Healing: Based on the Structure of Tips and Therapeutic Methodologies

Design Strategy of Microneedle Systems for Skin Wound Healing: Based on the Structure of Tips and Therapeutic Methodologies

A NIR‐II‐Emissive Organic Nanomedicine with Biomimetic Engineering for High‐Contrast Targeted Bioimaging and Multiple Phototherapies of Pancreatic Tumors

A Poly(2,7‐anthrylene) with peri‐Fused Porphyrin Edges

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