A nanomedicine enables synergistic chemo/photodynamic therapy for pancreatic cancer treatment

Zhu, Liwei; Lin, Shanmeng; Cui, Weihong; Xu, Youwei; Wang, Liang; Wang, Zhaohan; Yuan, Shuguang; Zhang, Yichuan; Fan, Yingfang; Geng, Jin

doi:10.1039/d2bm00437b

Cited by 14 publications

(7 citation statements)

References 48 publications

(63 reference statements)

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“…Fabrication of DAS/MB@M micelles PMAN-b-PTHPA (4.00 mg), DAS (dasatinib, 1.00 mg) and MB (methylene blue, 1.00 mg) were dissolved in 1.60 mL of DMF and then added dropwise to 14.40 mL of deionized water with stirring at room temperature for 30 min. According to the literature, 25,26 the solution was dialysed against deionized water (MWCO: 2000 Da) and then concentrated with an ultrafiltration centrifugal tube (MWCO: 3000 Da) at 4000 rpm and 4 °C.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-responsive glycopolymer micelles for targeted dual drug delivery in cancer therapy

Lin

Zhu

et al. 2023

Biomater. Sci.

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Section: Discussionmentioning

confidence: 99%

Ultrasound-responsive glycopolymer micelles for targeted dual drug delivery in cancer therapy

Lin

Zhu

et al. 2023

Biomater. Sci.

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“…In addition to strategies that enhance the effects of PDT, such as alleviating hypoxia and double PS, synergistic combinations of multiple therapeutic strategies are expected to improve the dismal efficacy of PDAC (for example, the combination of PDT and chemotherapy or immunotherapy). Zhu et al developed a PDAC treatment strategy that combines PDT, chemotherapy, and pro-apoptotic signals [ 137 ]. The nanosystem consists of Ce6 and a pro-apoptotic peptide-GEM conjugate.…”

Section: Well-designed Nanosystems For Different Pdac Therapeuticsmentioning

confidence: 99%

Recent Advances in Well-Designed Therapeutic Nanosystems for the Pancreatic Ductal Adenocarcinoma Treatment Dilemma

Yang

et al. 2023

Molecules

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Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with an extremely poor prognosis and low survival rate. Due to its inconspicuous symptoms, PDAC is difficult to diagnose early. Most patients are diagnosed in the middle and late stages, losing the opportunity for surgery. Chemotherapy is the main treatment in clinical practice and improves the survival of patients to some extent. However, the improved prognosis is associated with higher side effects, and the overall prognosis is far from satisfactory. In addition to resistance to chemotherapy, PDAC is significantly resistant to targeted therapy and immunotherapy. The failure of multiple treatment modalities indicates great dilemmas in treating PDAC, including high molecular heterogeneity, high drug resistance, an immunosuppressive microenvironment, and a dense matrix. Nanomedicine shows great potential to overcome the therapeutic barriers of PDAC. Through the careful design and rational modification of nanomaterials, multifunctional intelligent nanosystems can be obtained. These nanosystems can adapt to the environment’s needs and compensate for conventional treatments’ shortcomings. This review is focused on recent advances in the use of well-designed nanosystems in different therapeutic modalities to overcome the PDAC treatment dilemma, including a variety of novel therapeutic modalities. Finally, these nanosystems’ bottlenecks in treating PDAC and the prospect of future clinical translation are briefly discussed.

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“…For instance, in the design and development of a peptide− drug conjugate called Gem−Vinyldithioether−Smac N7, a vinyldithioether linker was utilized. 188 The prodrug was created by conjugating a peptide called Smac N7 and a drug called Gem using the vinyldithioether linker. The resulting nanomedicine was formed through self-assembly of the peptide−drug conjugate.…”

Section: Peroxalate Estermentioning

confidence: 99%

Cleavage and Noncleavage Chemistry in Reactive Oxygen Species (ROS)-Responsive Materials for Smart Drug Delivery

Chi,

Sang,

Wang

et al. 2023

Bioconjugate Chem.

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The design and development of advanced drug delivery systems targeting reactive oxygen species (ROS) have gained significant interest in recent years for treating various diseases, including cancer, psychiatric diseases, cardiovascular diseases, neurological diseases, metabolic diseases, and chronic inflammations. Integrating specific chemical bonds capable of effectively responding to ROS and triggering drug release into the delivery system is crucial. In this Review, we discuss commonly used conjugation linkers (chemical bonds) and categorize them into two groups: cleavable linkers and noncleavable linkers. Our goal is to clarify their unique drug release mechanisms from a chemical perspective and provide practical organic synthesis approaches for their efficient production. We showcase numerous significant examples to demonstrate their synthesis routes and diverse applications. Ultimately, we strive to present a comprehensive overview of cleavage and noncleavage chemistry, offering insights into the development of smart drug delivery systems that respond to ROS.

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A nanomedicine enables synergistic chemo/photodynamic therapy for pancreatic cancer treatment

Abstract: Pancreatic cancer is one of the leading causes of cancer-related death worldwide. Gemcitabine (Gem) has been the key chemotherapy for pancreatic cancer treatment by suppressing cell proliferation and inducing apoptosis....

Cited by 14 publications

References 48 publications

Ultrasound-responsive glycopolymer micelles for targeted dual drug delivery in cancer therapy

Ultrasound-responsive glycopolymer micelles for targeted dual drug delivery in cancer therapy

Recent Advances in Well-Designed Therapeutic Nanosystems for the Pancreatic Ductal Adenocarcinoma Treatment Dilemma

Cleavage and Noncleavage Chemistry in Reactive Oxygen Species (ROS)-Responsive Materials for Smart Drug Delivery

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