A nanoprobe for fluorescent monitoring of microRNA and targeted delivery of drugs

Chen, Zuo; Guo, Yongcan; Li, Junjie; Peng, Zhiping; Bai, Shulian; Yang, Shuangshuang; Wang, Ding; Chen, Hui

doi:10.1039/d1ra00154j

Cited by 17 publications

(5 citation statements)

References 32 publications

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“…[18] The application of CuS-NPs as a novel and economic agent for modifying porous nanoparticles can offer a two-sided effect in the forms of a therapeutic and diagnostic agent. [56] Particularly, the exertion of NH 2 -UiO-66 can enhance the luminescence properties of MOF for tracking and monitoring purposes [57,58] and also modify the release profile for increasing drug efficacy.…”

Section: Discussionmentioning

confidence: 99%

Five‐FU@CuS/NH₂‐UiO‐66 as a drug delivery system for 5‐fluorouracil to colorectal cancer cells

Gholami

Darroudi

Hekmat

et al. 2022

J Biochem & Molecular Tox

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In this study, copper sulfide nanoparticles (CuS‐NPs), which can improve the antiproliferative properties of conventional anticancer drugs such as 5‐fluorouracil (5‐FU), were incorporated into the pores of amine‐functionalized UiO‐66 (CuS/NH2‐UiO‐66). The introduced nano‐drug delivery system was exerted to perform an in vitro treatment on CT‐26 mouse colorectal cancer cells. The synthesized final product was labeled as 5‐FU@CuS/NH2‐UiO‐66 and characterized through conventional methods including X‐ray diffraction (XRD), Fourier transformation infrared spectroscopy (FT‐IR), Brunauer–Emmett–Teller (BET) analysis, Ultraviolet‐Visible (UV‐Vis) analysis, Inductively coupled plasma mass spectrometry (ICP‐MS), and 3‐(4,5‐dimethylthiazol‐2‐yl)−2,5‐diphenyltetrazolium bromide (MTT) assay. In contrast to 5‐FU, the outcomes of the cytotoxicity assay lacked any comparable results for 5‐FU@CuS/NH2‐UiO‐66.

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Section: Discussionmentioning

confidence: 99%

Five‐FU@CuS/NH₂‐UiO‐66 as a drug delivery system for 5‐fluorouracil to colorectal cancer cells

Gholami

Darroudi

Hekmat

et al. 2022

J Biochem & Molecular Tox

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“…[31] Huang et al reported an in situ electrostatic interactioncontrolled self-assembly strategy to pave a large number of smaller UCNPs (positively charged) onto the surface of largesize MOFs (negatively charged). To yield the core@satellite structure, ligand-free UCNPs (positively charged) were first Advantages and disadvantages UCNP@ZiF-8/FA Self-assembly Drug delivery [60] UCNP@MIL-53/FA PVP-modified Drug delivery [61] UCNP@MIL-100/Dox PVP-modified Drug delivery, UCL/MRI [62] UCNP@ZIF-90/DOX-FA SiO 2 -modified Drug delivery [63] UCNP@Al MOF PVP-modified PDT, CDT [64] UCNP@MOF/Dox DNA-mediated Drug delivery [65] UCNP@MIL-101(Fe)/FA Self-assembly CDT, acid [66] UCNP@MIL-100 PVP-modified - [67] UCNP@MIL-53 PVP-modified Photocatalysis [68] UCNP@ZIF-8@SNO PVP-modified Neurological [13] UCNP@MIL-100/PA PVP-modified CDT [12] UCNP@ZiF/RB PVP-modified CDT, PDT [69] UCNP@MIL-101(Cr) PVP-modified Photocatalysis [70] UCNP@ZiF SiO 2 -modified Biosensor [71] UCNPs@UiO-66 PAA-modified PDT, immunotherapy [72] Table 1. Continued.…”

Section: Core@satellite Structurementioning

confidence: 99%

Heterostructures Combining Upconversion Nanoparticles and Metal–Organic Framework: Fundamental, Classification, and Theranostic Applications

Tao

Zhang

et al. 2023

Advanced Optical Materials

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adom.202202122.ally inaccessible in existing endogenous and exogenous fluorophores in body. As a consequence, UCNPs hold promise as imaging agents for a myriad of biomedical applications, such as high contrast in vivo imaging and high-sensitivity biosensing. [3] Moreover, UCNPs can incorporate different functional lanthanide ions to impart new functional imaging modalities, such as trivalent gadolinium (Gd 3+ ) for magnetic resonance imaging (MRI) and ytterbium (Yb 3+ ) for X-ray computed tomography (CT), making them attractive for multimodal imaging. [4] Despite recent success of UCNPs on molecular imaging, the lack of therapeutic abilities precludes their uses as therapeutic agents for cancer treatment. Nowadays, combining complementary diagnostic and therapeutic abilities into one single nanoplatform, that is, "theranostic" agent, is on demand, in which the diagnostic role reports the presence of a disease, its status and its response to a specific treatment, while the therapeutic role implements imagingguided surgery, radiation therapy, light therapy, immunotherapy or chemotherapy to treat lesions, bringing about revolutionary advances in medicine and healthcare. Combining therapeutic agents and molecular imaging contrast agents to form heterostructures constitutes an essential means in developing theranostic agents, as it is of extreme difficulty to simultaneously achieve both diagnosis and therapy roles using single imaging or therapeutic alone.Metal-organic frameworks (MOFs) are distinguished exceptional for a set of forefront applications, including catalysis, security, environmental uses, and, especially, biotherapy. MOFs are highly crystallized porous materials formed by self-assembly of metal ions/metal clusters as nodes and organic ligands as link units, [5] which possess innate structural advantages of open pore structure, high porosity, and easily modified and functionalized surface, facilitating the confinement of chemotherapy drugs in the pores for diffusion-controlled drug delivery. [6] Moreover, certain photosensitizers such as tetrakis(4-carboxyphenyl)porphyrin (TCPP) can be used as the framing organic ligands, rendering MOF itself (e.g., as effective therapeutic drug, avoiding self-quenching of molecular photosensitizer, and thus producing higher amount of singlet oxygen ( 1 O 2 )

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“…[77] Recently, Xie et al fabricated DNA-hybrid-gated UCNPs@MOF/DOX nanocomposites for fluorescent detection of miRNA-21 (one of the oncogenic miRNAs overexpressed in various tumor cells) and on-demand drug delivery. [78] The 475 nm emission of UC-NPs upon NIR irradiation could be suppressed by DOX loaded in the pores of MOF shells due to efficient FRET. In the presence of target, miR-21 mediated toehold strand displacement reaction, leading to DNA gate collapse and release of DOX.…”

Section: Bioimaging and Biosensingmentioning

confidence: 99%

Heterostructures Made of Upconversion Nanoparticles and Metal–Organic Frameworks for Biomedical Applications

Liu

et al. 2021

Advanced Science

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Heterostructure nanoparticles (NPs), constructed by two single‐component NPs with distinct nature and multifunctional properties, have attracted intensive interest in the past few years. Among them, heterostructures made of upconversion NPs (UCNPs) and metal–organic frameworks (MOFs) can not only integrate the advantageous characteristics (e.g., porosity, structural regularity) of MOFs with unique upconverted optical features of UCNPs, but also induce cooperative properties not observed either for single component due to their special optical or electronic communications. Recently, diverse UCNP‐MOF heterostructures are designed and synthesized via different strategies and have demonstrated appealing potential for applications in biosensing and imaging, drug delivery, and photodynamic therapy (PDT). In this review, the synthesis strategies of UCNP‐MOF heterostructures are first summarized, then the authors focus mainly on discussion of their biomedical applications, particularly as PDT agents for cancer treatment. Finally, the authors briefly outlook the current challenges and future perspectives of UCNP‐MOF hybrid nanocomposites. The authors believe that this review will provide comprehensive understanding and inspirations toward recent advances of UCNP‐MOF heterostructures.

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A nanoprobe for fluorescent monitoring of microRNA and targeted delivery of drugs

Abstract: A DNA-hybrid-gated core–shell upconversion nanoprobe is prepared for both fluorescent monitoring of miR-21 and on-demand delivery of DOX. It showed good selectivity towards miR-21 and demonstrated specific cytotoxic efficacy towards MCF-7 cells.

Cited by 17 publications

References 32 publications

Five‐FU@CuS/NH₂‐UiO‐66 as a drug delivery system for 5‐fluorouracil to colorectal cancer cells

Five‐FU@CuS/NH₂‐UiO‐66 as a drug delivery system for 5‐fluorouracil to colorectal cancer cells

Heterostructures Combining Upconversion Nanoparticles and Metal–Organic Framework: Fundamental, Classification, and Theranostic Applications

Heterostructures Made of Upconversion Nanoparticles and Metal–Organic Frameworks for Biomedical Applications

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A nanoprobe for fluorescent monitoring of microRNA and targeted delivery of drugs

Abstract: A DNA-hybrid-gated core–shell upconversion nanoprobe is prepared for both fluorescent monitoring of miR-21 and on-demand delivery of DOX. It showed good selectivity towards miR-21 and demonstrated specific cytotoxic efficacy towards MCF-7 cells.

Cited by 17 publications

References 32 publications

Five‐FU@CuS/NH2‐UiO‐66 as a drug delivery system for 5‐fluorouracil to colorectal cancer cells

Five‐FU@CuS/NH2‐UiO‐66 as a drug delivery system for 5‐fluorouracil to colorectal cancer cells

Heterostructures Combining Upconversion Nanoparticles and Metal–Organic Framework: Fundamental, Classification, and Theranostic Applications

Heterostructures Made of Upconversion Nanoparticles and Metal–Organic Frameworks for Biomedical Applications

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Five‐FU@CuS/NH₂‐UiO‐66 as a drug delivery system for 5‐fluorouracil to colorectal cancer cells

Five‐FU@CuS/NH₂‐UiO‐66 as a drug delivery system for 5‐fluorouracil to colorectal cancer cells