A nanostructure-based electrochemical sensor for square wave voltammetric determination of N-acetylcysteine in pharmaceutical and biological samples

Arabali, Vahid; Karimi-Maleh, Hassan; Beitollahi, Hadi; Moradi, Reza; Ebrahimi, Mahmoud; Ahmar, Hamid

doi:10.1007/s11581-014-1271-4

Cited by 12 publications

(2 citation statements)

References 42 publications

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“…The monitoring of diseases, drug quality control as well as the evaluation about release of medicines in the environment depends of effective analytical methods development . In this sense, electrochemical sensors satisfy many of the requirements for such tasks, particularly owing to their ease of preparation, good selectivity and sensitivity, and fast response .…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Sensor Based on Multi‐walled Carbon Nanotubes and Cobalt Phthalocyanine Composite for Pyridoxine Determination

Porto

Silva

et al. 2019

Electroanalysis

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In this work, an electrochemical sensor based on pyrolytic graphite electrode (PGE), cobalt phthalocyanine (CoPc) and multiwalled carbon nanotube (MWCNT) composite designed as PGE‐MWCNT/CoPc was developed and validated for pyridoxine (vitamin B6) determination employing Differential Pulse Voltammetry (DPV). The electrochemical behaviour of pyridoxine at the PGE‐MWCNT/CoPc has been evaluated and the charge transfer coefficient, α, and the charge transfer rate constant, κ, were calculated as 0.30 and 11.67±0.43 s−1, respectively, which indicates that, although this system is irreversible, it is viable kinetically to be used as a sensor. The optimized experimental conditions were pH 5.5 in 0.30 mol L−1 phosphate buffer. The linear range found was 10 to 400 μmol L−1 of pyridoxine, with r=0.9987. The limits of detection and quantification were 0.50 and 1.67 μmol L−1, respectively, showing the good sensitivity of the method. The method was successfully applied for the pyridoxine determination in real samples of pharmaceutical formulation with RSD% lower than 5 % indicating that it can be used for routine quality control pharmaceutical formulations containing pyridoxine. Furthermore, it has the advantages of a fast response, a low detection limit and low cost.

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Section: Introductionmentioning

confidence: 99%

Electrochemical Sensor Based on Multi‐walled Carbon Nanotubes and Cobalt Phthalocyanine Composite for Pyridoxine Determination

Porto

Silva

et al. 2019

Electroanalysis

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“…N -AC overdose can be harmful because of its side effects such as diarrhea, upset stomach, skin rash, and fatigue [ 2 ]. A variety of analytical methods have been suggested for determination of N -AC in real samples such as spectrophotometry [ 3 – 6 ], chromatography [ 7 – 9 ], flow injection [ 10 ], fluorimetry [ 11 ], and electrochemical methods [ 12 , 13 ]. Compared to other analytical methods, electrochemical techniques are proposed for pharmaceutical, biological, and environmental detection owing to their fast response, low cost, good selectivity, and high sensitivity [ 14 – 25 ].…”

Section: Introductionmentioning

confidence: 99%

Application of novel Ni(II) complex and ZrO 2 nanoparticle as mediators for electrocatalytic determination of N -acetylcysteine in drug samples

Karimi-Maleh

Salehi

Faghani

2017

Journal of Food and Drug Analysis

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The electrooxidation of N-acetylcysteine (N-AC) was studied by a novel Ni(II) complex modified ZrO nanoparticle carbon paste electrode [Ni(II)/ZrO/NPs/CPE] using voltammetric methods. The results showed that Ni(II)/ZrO/NPs/CPE had high electrocatalytic activity for the electrooxidation of N-AC in aqueous buffer solution (pH = 7.0). The electrocatalytic oxidation peak currents increase linearly with N-AC concentrations over the concentration ranges of 0.05-600μM using square wave voltammetric methods. The detection limit for N-AC was equal to 0.009μM. The catalytic reaction rate constant, k, was calculated (7.01 × 10 M s) using the chronoamperometry method. Finally, Ni(II)/ZrO/NPs/CPE was also examined as an ultrasensitive electrochemical sensor for the determination of N-AC in real samples such as tablet and urine.

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Sensitive Electroanalytical Detection on GCE: the Case of Lipoic Acid and its Interaction with N‐acetylcysteine and Glutathione

Santos

Moura

Tanaka³

et al. 2016

Electroanalysis

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A simple and sensitive electrochemical method was developed for the determination of N‐Acetylcysteine (NAC) and Glutathione (GSH), on glassy carbon electrode. The results indicate that α‐lipoic acid (LipS2) is oxidized at the electrode, but is regenerated by thiols, suggesting a redox catalytic effect. Under optimized conditions, the analytical curves for NAC and GSH were obtained in the range of 1 up to 10 µM and 1 up to 60 µM, respectively. The quantification can be performed in a single assay with high sensitivity, reproducibility and low detection limit of 0.27 and 0.67 µM for NAC and GSH, respectively. This method was successfully applied to the determination of NAC and GSH in artificial saliva and human urine samples, with excellent recovery results.

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A nanostructure-based electrochemical sensor for square wave voltammetric determination of N-acetylcysteine in pharmaceutical and biological samples

Cited by 12 publications

References 42 publications

Electrochemical Sensor Based on Multi‐walled Carbon Nanotubes and Cobalt Phthalocyanine Composite for Pyridoxine Determination

Electrochemical Sensor Based on Multi‐walled Carbon Nanotubes and Cobalt Phthalocyanine Composite for Pyridoxine Determination

Application of novel Ni(II) complex and ZrO 2 nanoparticle as mediators for electrocatalytic determination of N -acetylcysteine in drug samples

Sensitive Electroanalytical Detection on GCE: the Case of Lipoic Acid and its Interaction with N‐acetylcysteine and Glutathione

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