A Nanostructured Conductive Hydrogels-Based Biosensor Platform for Human Metabolite Detection

Abstract

The development of a scalable, low-cost, and versatile biosensor platform for the sensitive and rapid detection of human metabolites is of great interest for healthcare, pharmaceuticals, and medical science. On the basis of hierarchically nanostructured conducting polymer hydrogels, we designed a flexible biosensor platform that can detect various human metabolites, such as uric acid, cholesterol, and triglycerides. Owing to the unique features of conducting polymer hydrogels, such as high permeability to biosubstrates and rapid electron transfer, our biosensors demonstrate excellent sensing performance with a wide linear range (uric acid, 0.07-1 mM; cholesterol, 0.3-9 mM, and triglycerides, 0.2-5 mM), high sensitivity, low sensing limit, and rapid response time (∼3 s). Given the facile and scalable processability of hydrogels, the proposed conductive hydrogels-based biosensor platform shows great promise as a low-cost sensor kit for healthcare monitoring, clinical diagnostics, and biomedical devices.

Nanostructured conducting polymer hydrogels for energy storage applications

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Reduced graphene oxide modified smart conducting paper for cancer biosensor

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Combined experimental and theoretical study of poly(aniline-co-pyrrole) oligomer

“…Advanced functional macromolecules such as conjugated organic polymers (COPs) [1][2][3] are promising due to their wide range of technological applications in the area of rechargeable batteries [4], optoelectronic devices [5], light emitting diodes [6], photovoltaic, sensors [7], biosensors [6,8], electrochromic display material, electromagnetic shielding [9], artificial muscles, and solar cell. Among COPs; poly (o-phenylenediamine) (POPD) [9], poly (3, 4-ethylenedioxythiophene) (PEDOT), polyparaphenylene (PPP), polyparaphenylenevenylene (PPV), polythiophene (PT), polypyrrole (PPy) [10], and polyaniline (PANI) have been studied both theoretically [11,12] and experimentally for efficient synthesis, characterization and applications [13][14][15].…”