A nanovaccine for antigen self-presentation and immunosuppression reversal as a personalized cancer immunotherapy strategy

Liu, Chao; Li, Xue; Xiang, Xinchu; Pang, Xin; Chen, Siyuan; Zhang, Yunming; Ren, En; Zhang, Lili; Li, Xuan; Lv, Peng; Wang, Xiaoyong; Luo, Wenxin; Xia, Ningshao; Chen, Xiaoyuan; Liu, Gang

doi:10.1038/s41565-022-01098-0

Cited by 195 publications

(135 citation statements)

References 46 publications

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“…To obtain anti-tumor cellular immunity, tumor-associated antigens must be captured by antigen-presenting cells (APCs) through major histocompatibility complex (MHC) I molecules and present them further to CD8 + T cells. However, in most cases, the intracellular exogenous antigens are usually decomposed by lysosomes and then guide the MHC II pathway, and evocative of CD4 + T cells results in subsequent humoral immunity rather than the desired cellular immunity [ 168 ]. Therefore, how to effectively deliver exogenous antigens through the MHC I pathway and further cross presentation is a scientific problem worth exploring.…”

Section: Calcium-based Nanomaterials For Cancer Diagnosis and Therapymentioning

confidence: 99%

Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy

Bai

Lan

et al. 2022

Nano-Micro Lett.

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As the indispensable second cellular messenger, calcium signaling is involved in the regulation of almost all physiological processes by activating specific target proteins. The importance of calcium ions (Ca2+) makes its “Janus nature” strictly regulated by its concentration. Abnormal regulation of calcium signals may cause some diseases; however, artificial regulation of calcium homeostasis in local lesions may also play a therapeutic role. “Calcium overload,” for example, is characterized by excessive enrichment of intracellular Ca2+, which irreversibly switches calcium signaling from “positive regulation” to “reverse destruction,” leading to cell death. However, this undesirable death could be defined as “calcicoptosis” to offer a novel approach for cancer treatment. Indeed, Ca2+ is involved in various cancer diagnostic and therapeutic events, including calcium overload-induced calcium homeostasis disorder, calcium channels dysregulation, mitochondrial dysfunction, calcium-associated immunoregulation, cell/vascular/tumor calcification, and calcification-mediated CT imaging. In parallel, the development of multifunctional calcium-based nanomaterials (e.g., calcium phosphate, calcium carbonate, calcium peroxide, and hydroxyapatite) is becoming abundantly available. This review will highlight the latest insights of the calcium-based nanomaterials, explain their application, and provide novel perspective. Identifying and characterizing new patterns of calcium-dependent signaling and exploiting the disease element linkage offer additional translational opportunities for cancer theranostics.

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Section: Calcium-based Nanomaterials For Cancer Diagnosis and Therapymentioning

confidence: 99%

Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy

Bai

Lan

et al. 2022

Nano-Micro Lett.

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“…Recently, engineered nanovaccines based on NVs were fabricated for boosting the ability to stimulate immune responses and regulating the tumor immunosuppressive microenvironment (8). Remarkably, the antigen self-presentation and immunosuppression reversal (ASPIRE) nanovaccine fabricated by Liu et al substituted dendritic cells for personalized cancer immunotherapy (9). ASPIRE is one of the NVs with an inherent ability of antigen presentation and was developed from the edited DCs, but the immune effect was better than that of DCs, and could even replace DCs to participate in the immune response.…”

Section: Introductionmentioning

confidence: 99%

Immunosuppression Reversal Nanovaccines Substituting Dendritic Cells for Personalized Cancer Immunotherapy

Cheng

Liang

et al. 2022

Front. Immunol.

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Although immunotherapy has paved a new avenue for cancer treatment, inadequate immune response often executes suboptimal therapeutic effects. In general, an effective immune response undergoes presentation of antigen by antigen-presenting cells, proliferation and differentiation of lymphocytes, and attack of cancer cells by cytotoxic T lymphocytes (CTLs). The antigen self-presentation and immunosuppression reversal (ASPIRE) nanovaccine derived from dendritic cells provides a simplified and immune deregulated procedure for immunotherapy profiting from its orientable peculiarity. By integrating major histocompatibility complex class I (MHC-I) molecules into present specific epitopes and co-delivering anti-PD-1 antibody and B7 costimulatory molecules through the programmed biomimetic synthesis, the ASPIRE nanovaccine demonstrates a milestone in personalized cancer immunotherapy.

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“…27 Liu et al developed a nanovaccine derived from DCs that genetically expressed a specific peptide-MHC complex, anti-PD1 antibody, and B7 costimulatory molecules to integrate antigen self-presentation and immunosuppression reversal. 28 Rosa et al showed that ectopic expression of a combination of transcription factors is useful to direct the reprogramming of fibroblasts into antigen-presenting DCs. 29 This reprogramming technology inspires the use of gene therapy to reprogram cancer cells into APCs in situ.…”

Section: Discussionmentioning

confidence: 99%