A narrative overview of the current status of MRI of the hip and its relevance for osteoarthritis research – what we know, what has changed and where are we going?

Crema, Michel D.; Watts, Gdj; Guermazi, Ali; Kim, Y.-J.; Kijowski, Richard; Roemer, Frank W.

doi:10.1016/j.joca.2016.08.015

Cited by 13 publications

(12 citation statements)

References 78 publications

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“…Radiographs are often used to evaluate hip OA but are insensitive to the soft-tissue findings seen in the early stages of OA 10 . Magnetic resonance imaging (MRI) provides superior soft-tissue contrast, enabling assessment of articular cartilage, labrum and other joint features 10,13,14 . Semi-quantitative MRI measures enable structured evaluation of soft-tissues involved in the pathogenesis of OA, with such approaches recommended for use in clinical studies of hip OA 13 .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of early hip OA features on MRI in high-impact athletes. The femoroacetabular impingement and hip osteoarthritis cohort (FORCe) study

Heerey

Srinivasan

Agricola

et al. 2021

Osteoarthritis and Cartilage

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Section: Introductionmentioning

confidence: 99%

Prevalence of early hip OA features on MRI in high-impact athletes. The femoroacetabular impingement and hip osteoarthritis cohort (FORCe) study

Heerey

Srinivasan

Agricola

et al. 2021

Osteoarthritis and Cartilage

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“…In our previous work, participants who were Black had more superior and medial narrowing (20), while superior or medial JSN were associated with radiographic HOA progression (40). Regarding phenotypes of hip OA, magnetic resonance imaging (MRI) may be useful in the future, given recent advances in technique and reproducibility as well as development of scoring systems with likely validity based on associations with radiography and pain in early work (41). Deep learning models are under development to extract information simultaneously and automatically about a variety of features (osteophytes, JSN, sclerosis, cysts) on radiographs with good accuracy in preliminary work (42).…”

Section: Discussionmentioning

confidence: 99%

Associations Between Baseline and Longitudinal Semiautomated Quantitative Joint Space Width at the Hip and Incident Hip Osteoarthritis: Data From a Community‐Based Cohort

Nelson

Smith

Álvarez

et al. 2022

Arthritis Care & Research

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Objective. To evaluate quantitative joint space width (JSW) at 10-, 30-, and 50-degree locations in relation to incident radiographic and symptomatic hip osteoarthritis (HOA) in a community-based cohort.Methods. Data were from Johnston County OA Project participants with supine hip radiographs at each of 4 time points; all had Kellgren/Lawrence (K/L) grades and quantitative JSW. We assessed covariates (age, race, height, weight, body mass index [BMI]) associated with quantitative JSW and hip-level associations between quantitative JSW and HOA over time using sex-stratified and multivariable-adjusted linear mixed models. A cluster analysis with logistic regression estimated associations between quantitative JSW trajectory groups and incident radiographic HOA and symptomatic HOA.Results. At baseline, 397 participants (784 hips, 41% men, 24% Black, mean age 57 years) had a mean BMI of 29 kg/m 2 . Over a mean of 18 years, 20% and 12% developed incident K/L grade-defined radiographic HOA or symptomatic HOA, respectively. Quantitative JSW was more sensitive to changes over time at 50 degrees. Values were stable among men but declined over time in women. Heavier women lost more quantitative JSW; changes in quantitative JSW were not significantly associated with race, education, or injury in women or men. In women only, loss of quantitative JSW over time was associated with 2-3 times higher odds of radiographic HOA and symptomatic HOA; among women and men, narrower baseline quantitative JSW was associated with these outcomes.Conclusion. Hip quantitative JSW demonstrates marked differences in respect to sex, with significant loss over time only in women. Loss of quantitative JSW over time in women and narrower baseline quantitative JSW in men and women were associated with incident radiographic HOA and symptomatic HOA.

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“…By contrast a comprehensive assessment of morphologic MR using semiquantitative scores and biochemically sensitive MRI techniques such as dGEMRIC can potentially overcome these limitations. 33 This could help avoid the otherwise inevitable second look operation for macroscopic or histologic evaluation of repair tissue. In a goat model, Watanabe et al .…”

Section: Discussionmentioning

confidence: 99%

Improved Cartilage Quality on Delayed Gadolinium-Enhanced MRI of Hip Cartilage after Subchondral Drilling of Acetabular Cartilage Flaps in Femoroacetabular Impingement Surgery at Minimum 5-Year Follow-Up

et al. 2020

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Objective To assess whether subchondral drilling of acetabular cartilage flaps during femoroacetabular impingement (FAI) surgery improves (1) acetabular dGEMRIC indices and (2) morphologic magnetic resonance imaging (MRI) scores, compared with hips in which no additional treatment of cartilage lesions had been performed; and (3) whether global dGEMRIC indices and MRI scores correlate. Design Prospective cohort study of consecutive patients with symptomatic FAI treated with open surgery between 2000 and 2007. Patients with subchondral drilling of acetabular cartilage flaps were allocated to the study group, those without drilling to the control group. All patients underwent indirect 3-T MR arthrography to assess cartilage quality by dGEMRIC indices and a semiquantitative morphologic MRI score at minimum 5 years after surgery. dGEMRIC indices and morphologic MRI scores were compared between and among groups using analysis of covariance/paired t tests. Results No significant difference was found between the global dGEMRIC indices of the study group (449 ± 147 ms, 95% CI 432-466 ms) and the control group (428 ± 143 ms, 95% CI 416-442 ms; P = 0.235). In regions with cartilage flaps, the study group showed higher dGEMRIC indices (472 ± 160 ms, 95% CI 433-510 ms) compared with the control group (390 ± 122 ms, 95% CI 367-413 ms; P < 0.001). No significant differences were found for the morphologic MRI scores. A strong inversely linear correlation between the dGEMRIC indices and the morphologic MRI scores ( r = −0.727, P < 0.001) was observed. Conclusions Treatment of acetabular cartilage flaps with subchondral drilling leads to better cartilage quality in regions with cartilage flaps at minimum 5 years of follow-up.

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A narrative overview of the current status of MRI of the hip and its relevance for osteoarthritis research – what we know, what has changed and where are we going?

Abstract: With the technical advances occurring in recent years, MRI may play a major role in investigating the natural history of hip OA and provide an improved method for assessment of the efficacy of new therapeutic approaches.

Cited by 13 publications

References 78 publications

Prevalence of early hip OA features on MRI in high-impact athletes. The femoroacetabular impingement and hip osteoarthritis cohort (FORCe) study

Prevalence of early hip OA features on MRI in high-impact athletes. The femoroacetabular impingement and hip osteoarthritis cohort (FORCe) study

Associations Between Baseline and Longitudinal Semiautomated Quantitative Joint Space Width at the Hip and Incident Hip Osteoarthritis: Data From a Community‐Based Cohort

Improved Cartilage Quality on Delayed Gadolinium-Enhanced MRI of Hip Cartilage after Subchondral Drilling of Acetabular Cartilage Flaps in Femoroacetabular Impingement Surgery at Minimum 5-Year Follow-Up

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