A narrative review of research progress on the relationship between hypoxia-inducible factor-2α and wound angiogenesis

Abstract

Objective: This article aims to pay attention to the latest research on the expression, activation and function of hypoxia-inducible factor-2α (HIF-2α) under hypoxia and non-hypoxia conditions, and summarizes the current knowledge about the interaction between hypoxia-inducible factor-2 and angiogenesis, hoping to understand its actions in physiology and disease, with the goal of providing a new strategy for the diagnosis and treatment of wounds.Background: Wound healing is a complex and continuous process, involving coagulation, inflammation, angiogenesis, new tissue formation and extracellular matrix remodeling. Of these, angiogenesis is an essential step. One of the main reasons for non-healing or delayed healing of wounds in peripheral vascular diseases and diabetes is the reduced ability to regenerate microvessels through the process of angiogenesis, which has become the focus of new methods for treating chronic wounds. HIF-2α regulates many aspects of angiogenesis, including vascular maturation, cell migration, proliferation and metastasis.Methods: Throughout extensive search of PubMed, summarize the medical research on HIF-2α to 2020.Conclusions: HIF-2α is necessary for normal embryonic development by stimulating the expression of angiogenic factors, such as vascular endothelial growth factor (VEGF). It is essential for the formation of new blood vessels in physiological and pathophysiological environments. Targeting HIF-2α in wound healing has much clinical significance for tissue repair.

miRNA-150_R-1 mediates the HIF-1/ErbB signaling pathway to regulate the adhesion of endometrial epithelial cells in cows experiencing retained placenta

“…HIF-2α can induce upregulation of erythropoietin, heme oxygenase, and other genes, leading to the production of many red blood cells and increasing oxygen transport throughout the body ( 29 ). HIF-2α can also induce upregulation of the receptor TGF-α, promoting the growth of epithelial cells and the formation of local BVs to improve local tissue oxygen supply ( 30 ). The signaling pathway of ErbB1, also known as EGFR, refers to multiple processes by which ErbB members dimerize or heterodimerize by binding to numerous signal transducers to promote autophosphorylation and subsequent downstream signaling cascades; regulatory transcription factors activate the transcription of genes that mediate cell migration and adhesion ( 31 ).…”

4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing

“…However, local oxygen tension askes much more oxygen and nutrient supply. Accordingly, HIF is increased its expression level and VEGF expression will be accompanied [ 27 , 28 ]. The expression of VEGF at this stage is mainly responsible for vasodilatation and increased vascular permeability [ 27 ].…”

“…In this point of view, surgeon may need TGF-β1-mediated VEGF expression, not HIF-mediated VEGF expression for uneventful and rapid wound healing. In other opinion, HIF-2α-mediated VEGF expression is important in capillary regeneration [ 28 ]. Interestingly, 4HR administration does induce neither HIF-1α nor HIF-2α [ 26 ].…”