A narrative review of the socioeconomic burden associated with generalised pustular psoriasis

Abstract

Generalised pustular psoriasis (GPP) is a rare, heterogeneous, chronic and potentially life-threatening autoinflammatory skin disease, characterised by episodes of widespread eruption of sterile, macroscopic pustules that occur with or without symptoms and signs of systemic inflammation. 1,2 The aberrant activation of the interleukin-36 pathway in patients with GPP causes an inflammatory reaction and widespread eruption of pustules. Flares, the acute phase of GPP involving widespread pustules, skin lesions and erythema, 3 typically last 2-5 weeks, 4 but may persist longer than 3 months and may be accompanied by systemic symptoms such as fever, pain, and fatigue. [5][6][7] While the most dominant cutaneous symptoms are pustules, erythema and scaling,

Knowledge Mapping and Research Hotspots of Generalized Pustular Psoriasis: A Bibliometric Analysis from 2003 to 2023

“… 4 It is now understood that GPP has an indirect impact on the economy through exacerbation of work productivity impairment. 5 However, a lack of global consensus on the clinical criteria for GPP diagnosis and treatment goal establishment persists. However, no consensus has been reached regarding the clinical criteria for diagnosing GPP and establishing treatment goals.…”

Understanding generalized pustular psoriasis for improved patient care

“…Patel PM et al highlight the large impact of GPP on patients' lives, emphasizing the need for routine assessment of QoL in individuals affected by the condition 12 . Zimmermann et al examine the socioeconomic impact of GPP on patients, healthcare systems and society as a whole, emphasizing the importance of increased awareness, improved access to care and targeted support systems 13 . To ensure comprehensive care, reliable online resources are essential.…”