A narrative review on the association of high intraocular pressure and glaucoma in patients with retinal vein occlusion

Jabbehdari, Sayena; Yazdanpanah, Ghasem; Cantor, Louis B.; Hajrasouliha, Amir Reza

doi:10.21037/atm-22-2730

Cited by 8 publications

(9 citation statements)

References 88 publications

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“…Many studies have examined the relationship between glaucoma, specifically POAG, and risk for RVO [4]. Yin et al demonstrated in their meta-analysis that POAG is significantly associated with RVO risk (OR: 5.03; 95% CI: 3.97 to 6.37) [3].…”

Section: Discussionmentioning

confidence: 99%

“…Glaucoma, an ocular disorder characterized by optic nerve damage and visual field loss, has been implicated in the pathogenesis of RVO [3]. Specifically, the association between RVO and primary open angle glaucoma (POAG) has been investigated in numerous studies, showing a significantly higher prevalence of RVO in patients with POAG compared to the general population [3,4]. Different pathogenic mechanisms have been proposed, implicating intraocular pressure which is a well-established and modifiable risk factor for glaucoma.…”

Section: Introductionmentioning

confidence: 99%

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Intraocular pressure, primary open-angle glaucoma and the risk of retinal vein occlusion: a Mendelian randomization mediation analysis

Katsimpris,

Baumeister,

Voulgari

et al. 2024

Preprint

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Background: The etiological connection between intraocular pressure (IOP) and the risk of retinal vein occlusion (RVO) remains elusive, particularly regarding whether this risk emanates from the direct influence of elevated intraocular pressure (IOP), irrespective of the presence of primary open-angle glaucoma (POAG), or if it arises as a consequence of the sequelae of POAG. Therefore, we conducted a Mendelian Randomization (MR) mediation analysis to elucidate the mediating role of POAG in the association between IOP and RVO. Methods: We identified 47 single-nucleotide polymorphisms (SNPs) associated with IOP (P-value < 5x10-8) leveraging data from a genome-wide association study (GWAS) (N = 97,653) obtained from the UK Biobank and 50 SNPs associated with POAG (P-value < 5x10-8) from a GWAS meta-analysis (16,677 cases and 199,580 controls). We related these SNPs with RVO using a GWAS of 775 RVO cases and 376,502 controls from FinnGen. By utilizing univariable and multivariable MR analyses we calculated the total effect of IOP on RVO and estimated the degree to which POAG mediates this association. Results: MR analyses showed that higher IOP is associated with higher RVO risk (odds ratio of RVO per 1 mmHg increase in IOP: 1.53; 95% confidence interval: 1.04 to 2.26; p-value = 0.03). Moreover, our MR mediation analysis suggested that 91.6% of the total effect of IOP on RVO risk was mediated through POAG. The primary results were consistent with estimates of pleiotropy-robust MR methods. Conclusion: Our findings suggest that higher IOP increases the risk of RVO and that the majority of this effect is mediated through POAG.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Intraocular pressure, primary open-angle glaucoma and the risk of retinal vein occlusion: a Mendelian randomization mediation analysis

Katsimpris,

Baumeister,

Voulgari

et al. 2024

Preprint

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“…6 High intraocular pressure is sometimes responsible for CRVO and has been documented in several case reports since the twentieth century but the reported case in this article had normal ocular pressure. 12,13,14 CRVO can be of two types. The mild type occurs due to leaky retinal vessels, manifesting with blurred vision on waking up in the morning and improving during the daytime.…”

Section: Discussionmentioning

confidence: 99%

A Hypertensive Early-Middle-Aged Man with Loss of Vision: a Rare Case of Primary Empty Sella Syndrome and Central Retinal Vein Occlusion

Salam MU,

Sakib MA,

Ahmad MM

et al. 2023

JSWMC

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Primary empty sella (PES) syndrome is a rare and benign condition usually with no symptoms, and, often revealed incidentally. But at times the syndrome manifests with a wide and variable range of ocular and endocrine features. Central retinal vein occlusion (CRVO) is in and of itself a rare cause of blindness, and its presence in the context of primary empty sella is even rarer. In this article, the authors report a case of a hypertensive man in his late thirties presenting to the medicine inpatient with headache and blindness of the left eye. Investigations came up with the diagnosis of PES syndrome with CRVO with macular edema. However, this patient had no overt endocrine problems.

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“…Although it has some common pathogenetic theories with the occurrence of retinal vein occlusions, they seem to be valid only for a small category of patients [ 4 ]. Several studies already demonstrated that glaucoma represents a higher risk for developing retinal vein occlusions [ 5 , 6 ], and the reasons seem to be the modifications produced at the lamina cribrosa, which consequently have an impact on the path of the vein passing through the optic nerve head [ 4 ]. Nevertheless, opinions and results vary when discussing the morphological and functional impact of glaucoma association with retinal vein occlusions.…”

Section: Introductionmentioning

confidence: 99%

Retinal vein occlusions associated or complicated with glaucoma. Aspects of prediction and paths of progression

Darabus

Pac

Munteanu

2023

rjo

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A narrative review on the association of high intraocular pressure and glaucoma in patients with retinal vein occlusion

Cited by 8 publications

References 88 publications

Intraocular pressure, primary open-angle glaucoma and the risk of retinal vein occlusion: a Mendelian randomization mediation analysis

Intraocular pressure, primary open-angle glaucoma and the risk of retinal vein occlusion: a Mendelian randomization mediation analysis

A Hypertensive Early-Middle-Aged Man with Loss of Vision: a Rare Case of Primary Empty Sella Syndrome and Central Retinal Vein Occlusion

Retinal vein occlusions associated or complicated with glaucoma. Aspects of prediction and paths of progression

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