A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in china

Fan, Jin‐Hu; Zhang, Yuqing; Shi, Susheng; Chen, Yuan‐Jia; Yuan, Xinghua; Jiang, Liming; Wang, Shaoming; Ma, Li; He, Yutong; Feng, Chang-Yan; Sun, Xin; Liu, Qing; Deloso, Katrina; Chi, Yihebali; Qiao, You‐Lin

doi:10.18632/oncotarget.17599

Cited by 82 publications

(78 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings are consistent with previous epidemiological data from other Asian series [5-8]. However, some variability exists in the incidence of GEPNEN in these Asian countries.…”

Section: Discussionsupporting

confidence: 92%

“…However, some variability exists in the incidence of GEPNEN in these Asian countries. A nation-wide retrospective epidemiological study of GEPNEN in China (2,010 patients) reported its incidence as 31.5% for the pancreas, 29.6% for the rectum and 27.0% for the stomach [8]. Similarly, a retrospective study from a tertiary medical centre in Hong Kong (126 patients), reported its incidence as 32% (pancreas), 30% (rectum) and 27% (stomach) [7].…”

Section: Discussionmentioning

confidence: 99%

“…Rectal NEN accounts for 25–48% of all GEPNEN/NEN in Asian series compared to 6–15% of all GEPNEN/NEN in Western groups [1-8, 13, 14]. While jejunal/ileum NEN accounts for 15–39% of all GEPNEN/NEN in Western series, its incidence in Asia is low (4–8%) [1-8, 13, 14]. …”

Section: Discussionmentioning

confidence: 99%

“…Epidemiological data of NEN have been described in some Asian countries with a homogeneous population [5-8]. There are similarities in the incidence of NEN shared among US Asian/Pacific Islander, Taiwan and Korean registries.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, pancreatic NEN is the most common primary tumour site in Hong Kong and China accounting for 35 and 32%, respectively. However, pancreatic NEN is much lower among US Asian/Pacific Islander (8%), Taiwan (6%) and Korean (9%) patients [1, 5, 6] compared to Hong Kong and China [7, 8]. …”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Clinicopathologic Characteristics and Survival of Patients with Gastroenteropancreatic Neuroendocrine Neoplasm in a Multi-Ethnic Asian Institution

Tai¹,

Tan²,

Tan³

et al. 2018

Neuroendocrinology

View full text Add to dashboard Cite

Background: Epidemiological evidence suggests there are differences in gastroenteropancreatic neuroendocrine neoplasm (GEPNEN) among population groups. We aimed to contribute to the current evidence by evaluating the clinicopathological characteristics of GEPNEN in a multi-ethnic Asian group. Materials and Methods: This was a retrospective chart review of patients diagnosed with GEPNEN at a tertiary medical institution at Singhealth Outram Campus, Singapore, between 1995 and 2015. Results: Two hundred ninety-five patients were included in the evaluation, comprising Chinese (74.6%), Malay (4.4%), Indian (9.5%) and other (11.5%) ethnic backgrounds. The median age at diagnosis was 59 years; 52.5% were males. Distribution of disease stage at diagnosis was: localised (42.4%), regional (15.3%) and distant (38.0%). The three most common primary tumour sites were located in the pancreas (38.6%), rectum (19.7%) and stomach (9.5%), which varied significantly with ethnic background and age at diagnosis. Malay patients were younger (median 42 years) at diagnosis than Chinese (60 years). Patients with an appendiceal neuroendocrine neoplasm (NEN) (48 years) were younger compared to oesophageal NEN (66 years). Disease stage correlated with primary tumour site and grade (p < 0.001). Median overall survival (OS) for all GEPNEN was 10.2 years. Age at diagnosis, disease stage and grading were prognostic factors of OS in multivariable analyses. Conclusion: Our findings correspond with other studies that focus on GEPNEN incidences in Asian countries, with the pancreas, rectum and stomach being the most common primary tumour sites. Our findings suggest racial differences in primary tumour site and age at diagnosis. Further prospective population-based registries are required to understand these epidemiological differences.

show abstract

“…Our findings are consistent with previous epidemiological data from other Asian series [5-8]. However, some variability exists in the incidence of GEPNEN in these Asian countries.…”

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinicopathologic Characteristics and Survival of Patients with Gastroenteropancreatic Neuroendocrine Neoplasm in a Multi-Ethnic Asian Institution

Tai¹,

Tan²,

Tan³

et al. 2018

Neuroendocrinology

View full text Add to dashboard Cite

show abstract

Clinical application of traditional Chinese medicine in the treatment of neuroendocrine neoplasms

Chen,

Hu,

et al. 2024

Advanced Chinese Medicine

View full text Add to dashboard Cite

Neuroendocrine neoplasms (NENs) are a group of rare tumors with strong heterogeneity. Among these tumors, well‐differentiated tumors can have a relatively good survival prognosis, while some tumors can have strong malignant potential and lead to increased mortality. Traditional Chinese medicine (TCM), which has a long history of thousands of years, has been widely used to treat tumors due to its unique advantages, such as economy, efficacy and few side effects. In recent years, the role of TCM in the treatment of NENs has gradually emerged. It can not only help prevent tumor recurrence and reduce the side effects of radiotherapy and chemotherapy but also relieve symptoms and improve quality of life. Various clinical studies have indicated that TCM has achieved good curative effects at different stages of treatment. We summarized the last 10 years of research progress on the clinical application of TCM in the treatment of NENs from four points of entry, aiming to provide a reference for the treatment of NENs.

show abstract

Surgical treatment for gastrointestinal neuroendocrine tumors

Eto

Yoshida

Iwagami

et al. 2020

Annals of Gastroent Surgery

View full text Add to dashboard Cite

Neuroendocrine tumors (NETs) are rare neoplasms, with an estimated annual incidence of 6.9/100 000. They arise from cells of the diffuse endocrine system, which are mainly dispersed throughout the gastrointestinal (GI), pancreatic, and respiratory tracts. The incidence of GI‐NETs has recently begun to show a steady increase. According to the Surveillance, Epidemiology, and End Results database, 53% of patients with NETs present with localized disease, 20% with locoregional disease, and 27% with distant metastases at the time of diagnosis. Surgery is the mainstay for the treatment of locoregional GI‐NETs. Endoscopic resection is an option for well‐differentiated early GI‐NETs, which are thought to very rarely metastasize to lymph nodes. A lesion that is technically difficult to resect via endoscopy is an indication for local resection (partial resection without lymph node dissection). GI‐NETs with possible lymph node metastasis is an indication for enterectomy with lymph node dissection. For NETs with metastatic lesions, cytoreduction surgery can control hormonal hypersecretion and alleviate symptoms; therefore, cytoreduction surgery is recommended. The indications for surgery vary and are based on the organ where the NET arose; therefore, an understanding of the patient's clinical state and individualized treatment that is based on the characteristics of the patient's GI‐NET is needed. This review summarizes surgical treatments of GI‐NETs in each organ.

show abstract

A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in china

Cited by 82 publications

References 29 publications

Clinicopathologic Characteristics and Survival of Patients with Gastroenteropancreatic Neuroendocrine Neoplasm in a Multi-Ethnic Asian Institution

Clinicopathologic Characteristics and Survival of Patients with Gastroenteropancreatic Neuroendocrine Neoplasm in a Multi-Ethnic Asian Institution

Clinical application of traditional Chinese medicine in the treatment of neuroendocrine neoplasms

Surgical treatment for gastrointestinal neuroendocrine tumors

Contact Info

Product

Resources

About