“…In the United States, testosterone formulations approved by the Food and Drug Administration (FDA) for testosterone replacement therapy (TRT) include intramuscular injections, transdermal patches, topical gels, implantable subcutaneous pellets, and buccal tablets [ [5] , [6] , [7] ]. Oral administration of testosterone is limited by low bioavailability due to poor gastrointestinal absorption and extensive first pass metabolism [ [1] , [2] , [3] , [4] ]. Intramuscular testosterone cypionate or enanthate have extended duration of action and are relatively inexpensive compared to other testosterone formulations [ [5] , [6] , [7] ].…”