A National Prospective Study on Childhood Celiac Disease in the Netherlands 1993–2000: An Increasing Recognition and a Changing Clinical Picture

Steens, Remy F.R.; Csizmadia, C.; George, Elvira K.; Ninaber, Maarten K; Sing, R.A. Hira; Mearin, M. Luisa

doi:10.1016/j.jpeds.2005.04.013

Cited by 76 publications

(63 citation statements)

References 25 publications

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“…Also, patients may present some gastrointestinal symptoms that were considered highly unusual for CD, such as constipation, vomiting and recurrent abdominal pain. Several recent studies have shown that typical symptoms of CD are absent in half of the newly diagnosed cases (9)(10)(11)(12). One in four patients with CD does not report any gastrointestinal symptomatology, as in our case.…”

Section: Discussionsupporting

confidence: 70%

Generalized edema with hypoproteinemia as initial presentation of celiac disease in a 3-year-old boy: case report

Ahel

Dežulović²,

Palčevski³

2015

Paediatr Croat

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Section: Discussionsupporting

confidence: 70%

Generalized edema with hypoproteinemia as initial presentation of celiac disease in a 3-year-old boy: case report

Ahel

Dežulović²,

Palčevski³

2015

Paediatr Croat

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“…5 Similar trends have been observed in Europe and North America over comparable time periods. [6][7][8][9][10] A number of articles also report that a greater proportion of children in more recent years are diagnosed through targeted screening and experience fewer GI symptoms. [7][8][9] However, no report has calculated the incidence of cases diagnosed over time because of a lower threshold to test or on the basis of the well-established classic presentation.…”

Section: (Continued On Last Page)mentioning

confidence: 99%

The Rising Incidence of Celiac Disease in Scotland

et al. 2013

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BACKGROUND AND OBJECTIVES: Although the incidence of pediatric celiac disease (CD) is increasing globally, it is uncertain whether this is attributed to improved case ascertainment or signifies a true rise. We aimed to identify all incident cases of childhood CD in southeast Scotland over the period 1990 to 2009 to assess trends in total incidence and cases diagnosed as a result of (1) a classic presentation, (2) a nonclassic presentation, or (3) targeted screening. METHODS: Twenty-year retrospective cohort study of case notes, pathology databases, endoscopy, and patient records for all children (<16 years of age) diagnosed with CD on biopsy in southeast Scotland (at-risk population of 225 000–233 000). Data were age-gender standardized and Poisson regression models used to calculate changes in incidence over time. RESULTS: A total of 266 children were diagnosed from 1990 to 2009 with an increase in incidence from 1.8/100 000 (95% confidence interval [CI] 1.1–2.7) to 11.7/100 000 (95% CI 9.8–13.9) between the epochs 1990 to 1994 and 2005 to 2009, respectively (P < .0001). The incidence of nonclassic presentation (children with a monosymptomatic presentation and those with extraintestinal symptoms) and actively screened cases increased by 1566% (P < .05) and 1170% (P < .001) from 1990 to 1999 to 2000 to 2009, respectively. However, a rise in the incidence of Oslo classic cases from 1.51/100 000 (95% CI 0.91–2.38) in 1990 to 1994 to 5.22/100 000 (95% CI 3.98–6.75) in 2005 to 2009 (P < .01) remained evident. CONCLUSIONS: The incidence of pediatric CD increased 6.4-fold over the 20 years. This study demonstrates that this rise is significant for classic CD, indicating a true rise in the incidence of pediatric CD.

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“…[8,9,10] For example, antibody testing for CD tripled the number of patients diagnosed with CD and quadrupled the median age of CD diagnosis. [11] On the other hand, the incidence of classic pediatric CD increased 6.4-fold over 20 years in Scotland, which strongly suggests a real increase in CD incidence [12].…”

Section: Epidemiologymentioning

confidence: 99%

Celiac Disease in Children: What Has Changed?

Nevoral

2016

IJCD

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The perception of celiac disease (CD) has changed dramatically during the last two decades, with the introduction of new serological tests with high specificity and sensitivity. CD prevalence in recent years is increasing as it is for other autoimmune diseases. Due to the high prevalence of CD, it is one of the most important diseases of the digestive tract. The clinical manifestations of CD have changed significantly in the last two decades, and these are much more diverse than reported previously. The new European Society for Pediatric Gastroenterology, Hepatology, and Nutrition diagnostic criteria for CD indicate that biopsy can be avoided in strictly selected groups of pediatric patients. The first experiences with these new criteria are positive. A meta-analysis evaluating the relationship between early nutrition and the risk of CD recommends that both early (< 4 months) and late (> 7 months) introduction of gluten to the diet should be avoided, and that gluten should be introduced while the infant is still breastfeeding. The prevalence rates of CD between two cohorts with different infant feeding practice were significantly different, and the prevalence of CD in 12-year-old children were significantly reduced, suggesting that prevention of CD is possible.

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A National Prospective Study on Childhood Celiac Disease in the Netherlands 1993–2000: An Increasing Recognition and a Changing Clinical Picture

Cited by 76 publications

References 25 publications

Generalized edema with hypoproteinemia as initial presentation of celiac disease in a 3-year-old boy: case report

Generalized edema with hypoproteinemia as initial presentation of celiac disease in a 3-year-old boy: case report

The Rising Incidence of Celiac Disease in Scotland

Celiac Disease in Children: What Has Changed?

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