A National Study of Outcomes among HIV-Infected Kidney Transplant Recipients

Locke, Jayme E.; Mehta, Shikha; Reed, Rhiannon D.; MacLennan, Paul A.; Massie, Allan B.; Nellore, Anoma; Durand, Christine M.; Segev, Dorry L.

doi:10.1681/asn.2014070726

Cited by 122 publications

(141 citation statements)

References 24 publications

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“…As mentioned, outcomes were inferior with kidney transplantation in patients coinfected with HIV and HCV when compared to HIV monoinfected transplant recipients [19,20] . Factors contributing to this may include HCV infection related increased risk for the development of post-transplant diabetes mellitus, liver damage, cardiovascular disease and infections.…”

Section: Patients Coinfected With Hiv and Hcvmentioning

confidence: 93%

“…Donor age, cold ischemia time of at least 16 h and delayed graft function were associated with a greater than four-fold increase in allograft loss among the HIV positive patients [18] . A recent study [19] . Mate kidney analyses using SRTR database from 2000 to 2013 showed similar long term outcomes of kidney transplantation in HIV positive patients relative to noninfected recipients.…”

Section: Nashar K Et Al Kidney Transplant In Hiv Infected Patientsmentioning

confidence: 97%

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Update on kidney transplantation in human immunodeficiency virus infected recipients

Nashar¹,

Sureshkumar²

2016

WJN

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Section: Patients Coinfected With Hiv and Hcvmentioning

confidence: 93%

Section: Nashar K Et Al Kidney Transplant In Hiv Infected Patientsmentioning

confidence: 97%

Update on kidney transplantation in human immunodeficiency virus infected recipients

Nashar¹,

Sureshkumar²

2016

WJN

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“…HUMAN IMMUNODEFICIENCY VIRUS 55 extensively studied. Experience from the Multicenter NIH HIV Organ Transplantation trial and many other centers now shows that overall outcomes are acceptable and improving with time, and in many cases now approximate outcomes similar to those seen in their HIV-negative counterparts (10)(11)(12). The subset of patients with hepatitis C virus and HIV coinfection, however, have significantly worse outcomes after kidney or liver transplantation as compared to their hepatitis C virus or HIV monoinfected counterparts, raising concerns about transplantation in this group.…”

Section: Transplantation In Hivmentioning

confidence: 99%

Human Immunodeficiency Virus

et al. 2016

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In this chapter we will discuss the diagnosis and monitoring of individuals with HIV infection. The application and interpretation of these tests does not change dramatically when used in the immunocompromised host. The principal approach to the diagnosis of HIV infection involves serologic testing, although nucleic acid amplification tests play an important role in the diagnosis of acute HIV infection. The algorithm for diagnosis of HIV continues to evolve with newer assays that are able to detect infection within an earlier timeframe after HIV transmission. Viral load testing for HIV-1 is the cornerstone for monitoring patients on antiretroviral therapy. Genotypic and phenotypic resistance tests are employed when antiretroviral resistance is suspected and results help guide therapy. The tropism assay must be performed to determine the efficacy of CCR5 chemokine receptor antagonists. Next-generation sequencing methods are an innovative approach to assessing archived antiretroviral resistance in patients with virologic suppression. The success of antiretroviral therapy with improved long-term outcomes has made transplantation in HIV-infected patients a reality.

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“…6 In 2010, the results from a nonrandomized National Institutes of Health (NIH)-sponsored clinical trial demonstrated excellent short-term outcomes, stability of HIVinfection, and few HIV-associated complications. 7 However, this trial contained a highly selected group of 150 patients with CD4…”

mentioning

confidence: 99%

“…The NIH trial suggested that tacrolimus was superior to cyclosporine in preventing rejection. 7 However, cyclosporine, which has in vitro activity against HCVand HIV, may be preferred for coinfected patients. 9 The role of sirolimus, which possesses intrinsic antiviral activity in addition to its ability to enhance the activity of other ARVs, also remains uncertain.…”

mentioning

confidence: 99%