A nationwide evaluation of deceased donor kidney transplantation indicates detrimental consequences of early graft loss

Abstract

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Donor characteristics and their impact on kidney transplantation outcomes: Results from two nationwide instrumental variable analyses based on outcomes of donor kidney pairs accepted for transplantation

“…Conclusions for sensitivity analyses that either included all EGL cases (i.e. also including those associated with early (≤90 day) mortality), respectively exclusively included primary transplantations ( Figure 1 B), 11 or that differentiated between conventional vs. expanded criteria donors (supplemental Figure 1) were similar to the primary analysis.…”

“…Nearly 85% of the EGL's were found to be asymmetrical. Since early (within 90-days) death following transplantation may relate to poor graft function, and incident EGL following retransplantation may involve accumulation of recipient-related risk-factors, 11 two sensitivity analysis were performed ( Figure 1 A). One for all procedures in recipients over 18, i.e.…”

Thymoglobulin Versus Alemtuzumab Versus Basiliximab Kidney Transplantation From Donors After Circulatory Death

“…Moreover, the patients in the thymoglobulin group had a significantly worse overall HLA and DR mismatch with their donors. Donor age, CIT and diabetes, are the most relevant risk factors for outcome in DCD transplants 3,7,27 and were similar in all groups. The survival analysis was performed unadjusted and adjusted to account for potential confounding risk factors.…”

Outcomes of small pediatric donor kidney transplants according to donor weight

“…In young adults, the recipient's sensitization was higher after a failed first deceased donor when compared with a living donor, with consequent delay to a second transplant [20]. Early graft loss in adult kidney recipients was associated with high mortality rates in the first few months after transplantation, low re-listing rates, and increased risk of a subsequent early graft loss [21,22]. However, the risk of long-term mortality was higher if one remained on the waiting list [21].…”