A nationwide study of maternal exposure to ambient ozone and term birth weight in the United States

Sun, Shengzhi; Wang, Jiajia; Cao, Wangnan; Wu, Lizhi; Tian, Yu; Sun, Feng; Zhang, Zhenyu; Ge, Yang; Du, Jianqiang; Li, Xiaobo; Chen, Rui

doi:10.1016/j.envint.2022.107554

Cited by 12 publications

(8 citation statements)

References 43 publications

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“…First, the average of gestational O 3 concentrations in our study was 46.4 ppb, which was higher than that by Sun et al. ( 10 ) (i.e., 39 to 40 ppb) or Lamichhane et al. ( 12 ) (43.0 ppb).…”

Section: Discussioncontrasting

confidence: 81%

“…Determining whether SGA or PTB predominately contributes to birthweight reduction across different regions is essential for public health interventions. Furthermore, the two pathways might play distinguishable roles at different trimesters, which resulted in one or several susceptible time windows to O 3 exposure identified by previous studies ( 10 , 12 , 17 ). Future research should explore these biological pathways underlying the burden of O 3 -related birthweight reduction using data with advanced quality.…”

Section: Discussionmentioning

confidence: 98%

“…The negative association between O 3 exposure and birthweight found in this study accords with the literature. Sun et al (10) analyzed more than 2 million singleton term births in the United States and found that each 10-ppb increment in O 3 during the pregnancy was associated with a reduction in birthweight of 7.6 g (95% CI: 6.4 to 8.8 g) and increasing odds of small for gestational age (SGA) by 3% (95% CI: 2 to 4%). Similarly, Guo et al (11) conducted a study in China including more than 2.5 million singleton term births.…”

Section: Discussionmentioning

confidence: 99%

“…Sun et al. ( 10 ) analyzed more than 2 million singleton term births in the United States and found that each 10-ppb increment in O 3 during the pregnancy was associated with a reduction in birthweight of 7.6 g (95% CI: 6.4 to 8.8 g) and increasing odds of small for gestational age (SGA) by 3% (95% CI: 2 to 4%). Similarly, Guo et al.…”

Section: Discussionmentioning

confidence: 99%

“…A meta-analysis reported that O 3 exposure throughout the entire pregnancy was associated with a birthweight reduction of 4.6 to 27.3 g for every 10-part per billion (ppb) increment in O 3 (9). Similarly, studies performed in the United States, China, and Korea reported birthweight reductions of 5.7 to 7.9 g per 10-ppb increment in O 3 exposure (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

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Estimating birthweight reduction attributable to maternal ozone exposure in low- and middle-income countries

Tong,

Xu,

Wang

et al. 2023

Sci. Adv.

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The effect of O 3 on birthweight in low- and middle-income countries (LMICs) remains unknown. A multicenter epidemiological study was conducted to evaluate the association between maternal peak-season O 3 exposure and birthweight, using 697,148 singleton newborns obtained in 54 LMICs between 2003 and 2019. We estimated the birthweight reduction attributable to peak-season O 3 exposure in 123 LMICs based on a nonlinear exposure-response function (ERF). With every 10–part per billion increment in O 3 concentration, we found a reduction in birthweight of 19.9 g [95% confidence interval (CI): 14.8 to 24.9 g]. The nonlinear ERF had a monotonic decreasing curve, and no safe O 3 exposure threshold was identified. The mean reduction in birthweight reduction attributable to O 3 across the 123 LMICs was 43.8 g (95% CI: 30.5 to 54.3 g) in 2019. The reduction in O 3 -related birthweight was greatest in countries in South Asia, the Middle East, and North Africa. Effective O 3 pollution control policies have the potential to substantially improve infant health.

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Section: Discussioncontrasting

confidence: 81%