A Nationwide Study on the Incidence of Rhegmatogenous Retinal Detachment in Denmark, With Emphasis on the Risk of the Fellow Eye

Hajari, Javad Nouri; Bjerrum, Søren Solborg; Christensen, Ulrik; Kiilgaard, Jens Folke; Bek, Toke; Cour, Morten la

doi:10.1097/iae.0000000000000104

Cited by 60 publications

(75 citation statements)

References 41 publications

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“…The validation of the NPR has been noted in a previous paper (Hajari et al. ). It showed that the NPR has a registration error of 0.36–3% and is thereby a valid register to use in epidemiological studies.…”

Section: Methodsmentioning

confidence: 76%

“…The study has some disadvantages, which have been discussed in a previous paper concerning data from the same registry (Hajari et al. ). Some of the disadvantages we previously have discussed are as follows: Assuring that no treatment has been conducted prior to the 5‐year lead period to ensure the initial operation is a primary RRD. Missed cases due to our search strategy. Lack of any clinical data in the register. …”

Section: Discussionmentioning

confidence: 99%

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Reoperation for rhegmatogenous retinal detachment as quality indicator for disease management: a register study

Hajari

Christensen

Kiilgaard

et al. 2015

Acta Ophthalmologica

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ABSTRACT.Purpose: To establish a quality indicator that could be used in optimizing treatment for rhegmatogenous retinal detachment (RRD). Methods: The Danish National Patient Registry was used to identify surgery conducted in Denmark for RRD in the period 01 January 2001-31 December 2009. Cases were identified by diagnosis and surgical codes. Results: A total of 6522 cases were operated for a primary RRD in the study period, and 22% (1434 patients) were reoperated for a redetachment. A Cox regression analysis showed that the risk of redetachment was equal to or less than detachment on the fellow eye 1 year after primary surgery with techniques not using silicone oil. The same was true 1.5 years after surgery for techniques using silicone oil. Based on this, we established a quality indicator defining failure as the need for operation for redetachment within 1 year from initial surgery when using techniques without oil and after 1.5 years for techniques using oil. Also the lack of oil removal within 1 year from initial surgery should be noted as an operational failure.We applied the quality indicators on the cohort of 6522 RRDs and found that in Denmark the need for redetachment surgery has decreased over time and also that high-volume departments have better outcome compared to smaller ones. Conclusions: The risk of reoperation for redetachment after initial surgery fulfils the criteria for a good quality indicator and can be used in RRD surgery. This indicator could aid in optimizing the management of RRD patients to minimize morbidity.

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Section: Methodsmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Reoperation for rhegmatogenous retinal detachment as quality indicator for disease management: a register study

Hajari

Christensen

Kiilgaard

et al. 2015

Acta Ophthalmologica

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“…; Hajari et al. ). Our results showed a predominance of males in the ratio of retinal detachments (approximately 1.8:1).…”

Section: Discussionmentioning

confidence: 97%

BAX and BCL‐2 polymorphisms, as predictors of proliferative vitreoretinopathy development in patients suffering retinal detachment: the Retina 4 project

Pastor‐Idoate

Rodríguez-Hernández

Rojas

et al. 2015

Acta Ophthalmologica

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ABSTRACT.Purpose: To compare the distribution of BCL-2 -938C>A (rs2279115) and BAX -248G>A (rs4645878) genotypes among European subjects undergoing rhegmatogenous retinal detachment (RRD) surgery in relation to the further development of proliferative vitreoretinopathy (PVR). Methods: A case-control gene association study, as a part of Retina 4 project, was designed. rs2279115 and rs4645878 polymorphisms were analysed in 555 samples from patients with RRD (134 with PVR secondary to surgery). Proportions of genotypes and AA homozygous groups of BCL-2 and BAX polymorphisms between subsamples were analysed in two phases. Genotypic and allelic frequencies were compared in global sample and in subsamples. Results: BAX: Differences were observed in the genotype frequencies and in AA carriers between controls and cases in the global series. The odds ratio (OR) of A carriers in the global sample was 1.7 (95% CI: 1.23-2.51). Proportions of genotypes in Spain + Portugal were significant different. The OR of A carriers from Spain and Portugal was 1.8 (95% CI: 1.11-2.95). BCL-2: No significant differences were observed in genotype frequencies. However, proportions of genotypes in Spain + Portugal were significant. A protective effect (OR: 0.6 95% CI: 0.43-0.96) was found in A carriers from Spain and Portugal. Conclusions: Results suggest that A allele of rs4645878 could be a biomarker of high risk of developing PVR in patients undergoing RD surgery. The possible role of BCL-2 (inhibitor of necroptosis pathway) as a possible new target in PVR prophylaxis should be investigated.

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“…Männer sind mit einer Ratio von 1,3:1 bis 2,3:1 (m:w) häufiger von rhegmatogenen Netzhautablö-sungen betroffen als Frauen [13, 16,17,19,25,26]. Einzelne Untersuchungen wiesen jedoch ein häufigeres Auftreten bei Frauen in der phaken nichttraumatischen Gruppe (Ratio m:w = 1,14:1,4) auf [14,18].…”

Section: Geschlechtunclassified

“…In den letzten Jahren finden sich nationale Registerstudien aus dem Vereinigten Königreich als auch aus Dänemark, bei denen eine systematische digitale Erfassung der durchgeführten Leistungen, Komplikationen und Folgeoperationen durchgeführt worden ist [26,54,55,56,57,58] [58]. Das größte Risiko der Entstehung einer pseudophaken Netzhautablösung wird in den ersten 6 Monaten nach der Operation beobachtet und flacht danach ab, bleibt aber sogar 10 Jahre nach der Kataraktoperation weiterhin erhöht.…”

Section: Kataraktoperationunclassified

Rhegmatogene Netzhautablösung

Bechrakis

Dimmer

2018

Ophthalmologe

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A Nationwide Study on the Incidence of Rhegmatogenous Retinal Detachment in Denmark, With Emphasis on the Risk of the Fellow Eye

Abstract: Patients with RRD on the first eye have a 100 times greater risk of developing RRD on the second eye, and the risk increases with male gender and surgery on the lens but decreases with age.

Cited by 60 publications

References 41 publications

Reoperation for rhegmatogenous retinal detachment as quality indicator for disease management: a register study

Reoperation for rhegmatogenous retinal detachment as quality indicator for disease management: a register study

BAX and BCL‐2 polymorphisms, as predictors of proliferative vitreoretinopathy development in patients suffering retinal detachment: the Retina 4 project

Rhegmatogene Netzhautablösung

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