A natural approach to breast cancer treatment: investigation of chemical features of aerial parts of endemic
            <i>Onosma sintenisii</i>
            Hausskn. ex Bornm and its antioxidant properties,
            <i>in vitro</i>
            cytotoxic and apoptosis induction on MCF-7 cells

Yıldırım, Metin; Binzet, Gun; Binzet, Rıza; Yabalak, Erdal

doi:10.1080/09603123.2024.2326182

International Journal of Environmental Health Research

2024

DOI: 10.1080/09603123.2024.2326182

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A natural approach to breast cancer treatment: investigation of chemical features of aerial parts of endemic Onosma sintenisii Hausskn. ex Bornm and its antioxidant properties, in vitro cytotoxic and apoptosis induction on MCF-7 cells

Metin Yıldırım,

Gun Binzet,

Rıza Binzet

et al.

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2024

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Cited by 3 publications

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Enhanced Anti‐Cancer Efficacy of Hesperidin through Smart Polymeric Nanoparticles Targeting Prostate Cancer

Yıldırım,

Acet,

Önal Acet

et al. 2024

ChemistrySelect

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The rapid progress of various nanotechnology tools is currently being utilized in the management of several fatal illnesses, including cancer. Nanopolymers that encapsulate anti‐cancer medication present a highly encouraging substitute to traditional therapies, primarily because of their specific targeting and accurate functionality, making them suitable for a variety of uses. Poly(2‐hydroxyethyl methacrylate) (pHEMA) is a non‐toxic polymer derived from the monomer HEMA, which is known for its toxicity. It can be combined with various other polymers and is associated with minimal immune response. The objective of the current investigation is to produce smart polymeric nanoparticles that are responsive to changes in pH and temperature, and capable of encapsulating hesperidin. These hesperidin‐loaded poly(2‐Hydroxyethyl methacrylate‐N‐isopropylacrylamide‐Vinyl imidazole) nanoparticles, referred to as HesSNPs, aim to enhance the bioavailability of hesperidin and augment its therapeutic effectiveness in combating prostate cancer. N‐isopropylacrylamide and Vinyl imidazole were employed as monomers sensitive to temperature and pH, respectively. Nanopolymers that were synthesized underwent characterization through dynamic light scattering (DLS) analyses, scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR) to analyze particle size and charge, surface morphology, and functional group determinations, respectively. HesSNPs decreased cell viability of DU‐145 cells. Flow cytometry analysis revealed that apoptosis is the main mechanism underlying cell death after HesSNPs treatment.

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Enhanced Anti‐Cancer Efficacy of Hesperidin through Smart Polymeric Nanoparticles Targeting Prostate Cancer

Yıldırım,

Acet,

Önal Acet

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

show abstract

Innovative approach against cancer: Thymoquinone-loaded PHEMA-based magnetic nanoparticles and their effects on MCF-7 breast cancer

Yıldırım,

Acet,

Önal Acet

et al. 2024

Biochemical and Biophysical Research Communications

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Chemical composition and antimicrobial activity of essential oils and various extracts of endemic Onosma malatyana (Boraginaceae) from Anatolia

Binzet,

Turunc,

Binzet

et al. 2024

International Journal of Environmental Health Research

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A natural approach to breast cancer treatment: investigation of chemical features of aerial parts of endemic Onosma sintenisii Hausskn. ex Bornm and its antioxidant properties, in vitro cytotoxic and apoptosis induction on MCF-7 cells

Cited by 3 publications

References 55 publications

Enhanced Anti‐Cancer Efficacy of Hesperidin through Smart Polymeric Nanoparticles Targeting Prostate Cancer

Enhanced Anti‐Cancer Efficacy of Hesperidin through Smart Polymeric Nanoparticles Targeting Prostate Cancer

Innovative approach against cancer: Thymoquinone-loaded PHEMA-based magnetic nanoparticles and their effects on MCF-7 breast cancer

Chemical composition and antimicrobial activity of essential oils and various extracts of endemic Onosma malatyana (Boraginaceae) from Anatolia

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