A natural food preservative peptide nisin can interact with the SARS-CoV-2 spike protein receptor human ACE2

Bhattacharya, Rajarshi; Gupta, Aayatti Mallick; Mitra, Suranjita; Mandal, Sukhendu; Biswas, Swadesh Ranjan

doi:10.1016/j.virol.2020.10.002

Cited by 37 publications

(32 citation statements)

References 21 publications

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“…Modification of existing natural AMPs is an attractive approach, since it can lead to the creation of new antiviral therapeutic agents [ 11 ]. The study shows the promise of using nisin, a dietary AMP produced by lactic acid bacteria, which can bind to hACE2, competitively inhibiting RBD SARS-CoV-2 [ 283 ]. Against COVID-19, it is proposed to use an AMP such as lactoferrin (LF), which is an iron-binding glycoprotein.…”

Section: Prediction and Development Of New Ampsmentioning

confidence: 99%

Antimicrobial and Amyloidogenic Activity of Peptides. Can Antimicrobial Peptides Be Used against SARS-CoV-2?

Kurpe

Grishin

Surin

et al. 2020

IJMS

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At present, much attention is paid to the use of antimicrobial peptides (AMPs) of natural and artificial origin to combat pathogens. AMPs have several points that determine their biological activity. We analyzed the structural properties of AMPs, as well as described their mechanism of action and impact on pathogenic bacteria and viruses. Recently published data on the development of new AMP drugs based on a combination of molecular design and genetic engineering approaches are presented. In this article, we have focused on information on the amyloidogenic properties of AMP. This review examines AMP development strategies from the perspective of the current high prevalence of antibiotic-resistant bacteria, and the potential prospects and challenges of using AMPs against infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

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Section: Prediction and Development Of New Ampsmentioning

confidence: 99%

Antimicrobial and Amyloidogenic Activity of Peptides. Can Antimicrobial Peptides Be Used against SARS-CoV-2?

Kurpe

Grishin

Surin

et al. 2020

IJMS

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“…This observation showed the way for exploring the potential of beneficial bacteria and cultured products in the alleviation of human and animal disorders [1,10]. Likewise, more recent studies have confirmed the ability of probiotic bacteria and their bioactive metabolites to act effectively towards flattening the curve of the COVID-19 pandemic as they exhibit immunomodulatory and antiviral properties [11][12][13][14].…”

Section: Historical Pathway Of Fermented Milk In Human Nutritionmentioning

confidence: 78%

Kefir as a Functional Beverage Gaining Momentum towards Its Health Promoting Attributes

et al. 2021

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The consumption of fermented foods posing health-promoting attributes is a rising global trend. In this manner, fermented dairy products represent a significant subcategory of functional foods with established positive health benefits. Likewise, kefir—a fermented milk product manufactured from kefir grains—has been reported by many studies to be a probiotic drink with great potential in health promotion. Existing research data link regular kefir consumption with a wide range of health-promoting attributes, and more recent findings support the link between kefir’s probiotic strains and its bio-functional metabolites in the enhancement of the immune system, providing significant antiviral effects. Although it has been consumed for thousands of years, kefir has recently gained popularity in relation to novel biotechnological applications, with different fermentation substrates being tested as non-dairy functional beverages. The present review focuses on the microbiological composition of kefir and highlights novel applications associated with its fermentation capacity. Future prospects relating to kefir’s capacity for disease prevention are also addressed and discussed.

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“…Blocking this phenomenon has huge potentials to stop the infection of virus and finding RBD inhibitors is of huge potentials, where researchers have even tried to block RBD with Human recombinant soluble ACE2 and other similar peptides [ [35] , [36] , [37] , [38] , [39] , [40] ]. A natural food preservative peptide nisin can interact with the SARS-CoV-2 spike protein receptor human ACE2 is reported [ 41 ]. Fusion inhibitor, and the S-protein inhibitors in current study specifically inhibit this process of membrane fusion stopping the entry of viral components entering into the host cell [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Pinpointing the potential hits for hindering interaction of SARS-CoV-2 S-protein with ACE2 from the pool of antiviral phytochemicals utilizing molecular docking and molecular dynamics (MD) simulations

Patel

Goswami

Jaiswal

et al. 2021

Journal of Molecular Graphics and Modelling

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SARS-CoV-2, the viral particle, is responsible for triggering the 2019 Coronavirus disease outbreak (COVID-19). To tackle this situation, a number of strategies are being devised to either create an antidote, a vaccine, or agents capable of preventing its infection. To enable research on these strategies, numerous target proteins are identified where Spike (S) protein is presumed to be of immense potential. S-protein interacts with human angiotensin-converting-enzyme-2 (ACE2) for cell entry. The key region of S-protein that interacts with ACE2 is a portion of it designated as a receptor-binding domain (RBD), following whereby the viral membrane fuses with the alveolar membrane to enter the human cell. The proposition is to recognise molecules from the bundle of phytochemicals of medicinal plants known to possess antiviral potentials as a lead that could interact and mask RBD, rendering them unavailable to form ACE2 interactions. Such a molecule is called the 'S-protein blocker’. A total of 110 phytochemicals from Withania somnifera , Asparagus racemosus, Zinziber officinalis , Allium sativum , Curcuma longa and Adhatoda vasica were used in the study, of which Racemoside A, Ashwagandhanolide, Withanoside VI, Withanoside IV and Racemoside C were identified as top five hits using molecular docking. Further, essential Pharmacophore features and their ADMET profiles of these compounds were studied following to which the best three hits were analyzed for their interaction with RBD using Molecular Dynamics (MD) simulation. Binding free energy calculations were performed using MM/GBSA, proving these phytochemicals can serve as S-protein blocker.

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A natural food preservative peptide nisin can interact with the SARS-CoV-2 spike protein receptor human ACE2

Cited by 37 publications

References 21 publications

Antimicrobial and Amyloidogenic Activity of Peptides. Can Antimicrobial Peptides Be Used against SARS-CoV-2?

Antimicrobial and Amyloidogenic Activity of Peptides. Can Antimicrobial Peptides Be Used against SARS-CoV-2?

Kefir as a Functional Beverage Gaining Momentum towards Its Health Promoting Attributes

Pinpointing the potential hits for hindering interaction of SARS-CoV-2 S-protein with ACE2 from the pool of antiviral phytochemicals utilizing molecular docking and molecular dynamics (MD) simulations

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