2024
DOI: 10.1111/bph.16377
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A natural inhibitor of diapophytoene desaturase attenuates methicillin‐resistant Staphylococcus aureus (MRSA) pathogenicity and overcomes drug‐resistance

Baoqing Han,
Hongsu Wang,
Xiaodi Niu

Abstract: Background and PurposeAt present, the inhibition of staphyloxanthin biosynthesis has emerged as a prominent strategy in combating methicillin‐resistant Staphylococcus aureus (MRSA) infection. Nonetheless, there remains a limited understanding regarding the bio‐structural characteristics of staphyloxanthin biosynthetic enzymes, as well as the molecular mechanisms underlying the interaction between inhibitors and proteins. Furthermore, the functional scope of these inhibitors is relatively narrow.Experimental Ap… Show more

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