A natural interomone 2-methyl-2-butenal stimulates feed intake and weight gain in weaned pigs

McGlone, John J.; Thompson, Glenda Sue; Sankarganesh, Devaraj

doi:10.1017/s1751731116001439

Cited by 9 publications

(7 citation statements)

References 9 publications

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“…Maternal semiochemicals have been shown to improve weaning piglet performance. For instance, the pig appeasing pheromone and the rabbit maternal pheromone (2-methyl-2-butenal) reduced aggression and improved performance when sprayed on the feeders of weaned piglets [30,31]. Thus, it is possible that sow feces contain natural maternal semiochemicals that promote health and performance.…”

Section: Discussionmentioning

confidence: 99%

Preliminary Study: Depriving Piglets of Maternal Feces for the First Seven Days Post-Partum Changes Piglet Physiology and Performance before and after Weaning

Aviles-Rosa

Rakhshandeh

McGlone

2019

Animals

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Coprophagy has been described in piglets although its importance has not been fully assessed. The aim of this study was to evaluate how deprivation of maternal feces influenced piglet physiology, behavior, and performance. Eight litters were randomly assigned to one of two treatments. Control (CON) litters had access to maternal feces while deprived (DEP) litters were deprived of maternal feces for the first 7 d post-partum. Piglet behavior was quantified for 24 h at 7 d of age. Blood samples were collected from one male and female from each litter at 0, 7, and 21 d for hematological analyses, and post-weaning performance was assessed until 123 d post-weaning. No treatment effects were observed on piglet behavior. DEP piglets had 25% lower leukocyte counts (p < 0.01). Relative to DEP litters, CON litters had increased post-weaning feed intake (0.998 vs 0.901 kg/d; p = 0.02) and weight gain (0.536 vs 0.483 kg/d; p < 0.01). At 123 d post-weaning, CON pigs were 9.3 ± 2.3 kg heavier than treatment pigs (p < 0.01). These results suggest that access to maternal feces improves immunocompetence and growth performance. Further studies are needed to explore the physiological mechanisms through which maternal feces improve growth performance, including nutritional and microbial factors, or the presence of maternal semiochemicals.

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Section: Discussionmentioning

confidence: 99%

Preliminary Study: Depriving Piglets of Maternal Feces for the First Seven Days Post-Partum Changes Piglet Physiology and Performance before and after Weaning

Aviles-Rosa

Rakhshandeh

McGlone

2019

Animals

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“…Change of handlers does not change VSA pattern. To test the repeatability of VSAs and also understand whether different handlers would have different impacts on mouse voiding patterns, such as through interomone (pheromone affecting other species) signaling mechanisms (18,19), a male (~30 yr old) and a female handler (~30 yr old) performed VSA in standard and new rectangular cages. Our data indicated that in both types of cages the handler had no effect on voiding patterns (Tables 6 and 7).…”

Section: Resultsmentioning

confidence: 99%

Evaluating the voiding spot assay in mice: a simple method with complex environmental interactions

Chen

Zhang

Hill

et al. 2017

American Journal of Physiology-Renal Physiology

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The voiding spot assay (VSA) on filter paper is an increasingly popular method for studying lower urinary tract physiology in mice. However, the ways VSAs are performed differ significantly between laboratories, and many variables are introduced compared with the mouse's normal housing situation. Rodents are intelligent social animals, and it is increasingly understood that social and environmental stresses have significant effects on their physiology. Surprisingly, little is known about whether change of environment during VSA affects mouse voiding and what the best methodologies are for retaining "natural" micturition patterns. It is well known that stress-related neuropeptide corticotropin-releasing factor is significantly elevated and induces dramatic voiding changes when rodents encounter stresses. Therefore we hypothesized that changes in the environmental situation could potentially alter voiding during VSA. We have examined multiple factors to test whether they affect female mouse voiding patterns during VSA, including cage type, cage floor, water availability, water bottle location, single or group housing, and different handlers. Our results indicate that mice are surprisingly sensitive to changes in cage type and floor surface, water bottle location, and single/group housing, each of which induces significant changes in voiding patterns, indicative of a stress response. In contrast, neither changing handler nor 4 h of water deprivation affected voiding patterns. Our data indicate that VSA should be performed under conditions as close as possible to the mouse's normal housing. Optimizing VSA methodology will be useful in uncovering voiding alterations in both genetic and disease models of lower urinary dysfunctions.

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“…However, when this product was tried on commercial farms, it had minimal or no efficacy for the weaned pig (we believed the commercial environment was too odorous and thus required a stronger olfactory signal). We then examined the rabbit MP (2-Methyl-2-Butenal, 2M2B) as a potential Interomone and, again, found a reliable reduction in fighting and an increase in feeding ( 59 ) in our controlled university high-health farm. Again, as with PAP when we took 2M2B it to the field, we could not replicate its positive effects with a large number of commercial pigs.…”

Section: Semiochemicals In Domestic Pigsmentioning

confidence: 99%

Interpretive review: Semiochemicals in domestic pigs and dogs

McGlone

Archer²,

Henderson³

2022

Front. Vet. Sci.

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This interpretive review includes discussion of the available scientific literature with interpretations by the authors. The broad field of semiochemicals can be confusing to scientists and consumers. This review attempts to summarize the known scientific studies for pig and dog semiochemicals while at the same time attempting to refine our use of terminology. The specific objectives of this interpretive review are to summarize and interpret much of the key scientific literature (but not the lay literature) on semiochemicals in pigs and dogs to include (1) definitions of semiochemicals and related molecules including pheromones, (2) to briefly summarize olfactory organs, and (3) and to examine the scientific literature for semiochemical mechanisms and applications in dogs and pigs (two domesticated species with known olfactory acuity). Dogs and pigs have olfactory features that are similar in that they both lack certain olfactory organs (Grueneberg ganglion and Septal Organ) and they have a small vomeronasal organ (VNO) without some major receptors that are found in other species. The primary olfactory organs for both pigs and dogs are the main olfactory epithelium and perhaps the trigeminal nerve. Several examples of pheromones activating the brain via the MOE or Trigeminal nerve rather than the VNO challenge the concept that the VNO is the site of pheromone sensing. We believe it is not appropriate to label something a pheromone when evidence is not available to show that it is a pheromone. We offer definitions for the terms semiochemicals, pheromones, interomones and others and then determine if the evidence is sufficient to call certain semiochemicals a pheromone. Here we review mixed, largely negative, scientific reports of the efficacy of some products labeled as “pheromones” that are more appropriately called semiochemicals. Interomones can have a more powerful effect on dog behavior and physiology than semiochemicals marketed as pheromones. Because marketing of semiochemicals is far ahead of the science, bringing some logic and uniformity to the field will benefit animals and hopefully cause less consumer confusion. Semiochemicals have the potential to offer powerful solutions to behavioral problems using more naturally occurring molecules.

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A natural interomone 2-methyl-2-butenal stimulates feed intake and weight gain in weaned pigs

Cited by 9 publications

References 9 publications

Preliminary Study: Depriving Piglets of Maternal Feces for the First Seven Days Post-Partum Changes Piglet Physiology and Performance before and after Weaning

Preliminary Study: Depriving Piglets of Maternal Feces for the First Seven Days Post-Partum Changes Piglet Physiology and Performance before and after Weaning

Evaluating the voiding spot assay in mice: a simple method with complex environmental interactions

Interpretive review: Semiochemicals in domestic pigs and dogs

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