A natural polymer-based hydrogel with shape controllability and high toughness and its application to efficient osteochondral regeneration

Yang, Jueying; Wang, Hui; Huang, Wei-Ting; Peng, Kelin; Shi, Rui; Tian, Wei; Yuan, Jingjing; Lin, Lizhi; Yao, Weishang; Ma, Xinzhi; Chen, Yu

doi:10.1039/d3mh00544e

Cited by 16 publications

(4 citation statements)

References 53 publications

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“…Finally, the robust self-powered hydrogels were obtained by immersing the original hydrogels in a bimetallic salt solution, which was based on the salting-out effect, metal coordination, and electrostatic interactions. [34][35][36] In comparison to methods such as photopolymerization and thermally induced techniques for hydrogel preparation, this study did not involve the use of any environmentally unfriendly initiators or solvents. Instead, the process is rapid, green, and utilizes environmentally friendly polymers as raw materials.…”

Section: Design Of Polysaccharide-based Hydrogelsmentioning

confidence: 99%

Constructing robust and recyclable self-powered polysaccharide-based hydrogels by adjusting Zn²⁺/Li⁺ bimetallic networks

Zhou,

Yang,

et al. 2024

Green Chem.

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Section: Design Of Polysaccharide-based Hydrogelsmentioning

confidence: 99%

Constructing robust and recyclable self-powered polysaccharide-based hydrogels by adjusting Zn²⁺/Li⁺ bimetallic networks

Zhou,

Yang,

et al. 2024

Green Chem.

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“…The matrices of the hybrid hydrogels could use various organics, including natural polymers and man-made polymer materials, which demonstrated the biocompatibility of antibacterial agents and controlled as well as the sustained release of antibacterial agents. It is worth mentioning that some antibacterial agents could enhance the mechanical properties of the hydrogels, including strength and toughness while imparting antibacterial properties to the hydrogel [ 225 , 226 ]. At present, the antibacterial hydrogels are widely used in wound dressings to treat wound infections, contact lenses, urinary tract coatings, catheter-associated infections, gastrointestinal infections, treatment of osteomyelitis, and so on [ 90 , 227 – 231 ].…”

Section: Conclusion and Prospectmentioning

confidence: 99%

Advances in preparation and application of antibacterial hydrogels

Tang,

Xu,

Wang

et al. 2023

J Nanobiotechnol

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Bacterial infections, especially those caused by drug-resistant bacteria, have seriously threatened human life and health. There is urgent to develop new antibacterial agents to reduce the problem of antibiotics. Biomedical materials with good antimicrobial properties have been widely used in antibacterial applications. Among them, hydrogels have become the focus of research in the field of biomedical materials due to their unique three-dimensional network structure, high hydrophilicity, and good biocompatibility. In this review, the latest research progresses about hydrogels in recent years were summarized, mainly including the preparation methods of hydrogels and their antibacterial applications. According to their different antibacterial mechanisms, several representative antibacterial hydrogels were introduced, such as antibiotics loaded hydrogels, antibiotic-free hydrogels including metal-based hydrogels, antibacterial peptide and antibacterial polymers, stimuli-responsive smart hydrogels, and light-mediated hydrogels. In addition, we also discussed the applications and challenges of antibacterial hydrogels in biomedicine, which are expected to provide new directions and ideas for the application of hydrogels in clinical antibacterial therapy.

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“…Therefore, they need to have a good degradation ability, biological activity, cell response, and suitable mechanical properties [ 1 ]. At present, there are many different types of materials applied in bone scaffolds including polymers, ceramics, and metals; they each have their own advantages and disadvantages [ 2 , 3 , 4 ]. Synthetic polymers are currently the most widely studied scaffold materials, especially biodegradable polymer materials [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Magnesium Hydroxide as a Versatile Nanofiller for 3D-Printed PLA Bone Scaffolds

Guo,

Bu,

Mao

et al. 2024

Polymers

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Polylactic acid (PLA) has attracted much attention in bone tissue engineering due to its good biocompatibility and processability, but it still faces problems such as a slow degradation rate, acidic degradation product, weak biomineralization ability, and poor cell response, which limits its wider application in developing bone scaffolds. In this study, Mg(OH)2 nanoparticles were employed as a versatile nanofiller for developing PLA/Mg(OH)2 composite bone scaffolds using fused deposition modeling (FDM) 3D printing technology, and its mechanical, degradation, and biological properties were evaluated. The mechanical tests revealed that a 5 wt% addition of Mg(OH)2 improved the tensile and compressive strengths of the PLA scaffold by 20.50% and 63.97%, respectively. The soaking experiment in phosphate buffered solution (PBS) revealed that the alkaline degradation products of Mg(OH)2 neutralized the acidic degradation products of PLA, thus accelerating the degradation of PLA. The weight loss rate of the PLA/20Mg(OH)2 scaffold (15.40%) was significantly higher than that of PLA (0.15%) on day 28. Meanwhile, the composite scaffolds showed long-term Mg2+ release for more than 28 days. The simulated body fluid (SBF) immersion experiment indicated that Mg(OH)2 promoted the deposition of apatite and improved the biomineralization of PLA scaffolds. The cell culture of bone marrow mesenchymal stem cells (BMSCs) indicated that adding 5 wt% Mg(OH)2 effectively improved cell responses, including adhesion, proliferation, and osteogenic differentiation, due to the release of Mg2+. This study suggests that Mg(OH)2 can simultaneously address various issues related to polymer scaffolds, including degradation, mechanical properties, and cell interaction, having promising applications in tissue engineering.

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A natural polymer-based hydrogel with shape controllability and high toughness and its application to efficient osteochondral regeneration

Abstract: Hydrogels prepared from sustainable natural polymers have broad prospects in the biological field. However, their poor mechanical properties and challenges in achieving shape control have limited their application. Herein, a...

Cited by 16 publications

References 53 publications

Constructing robust and recyclable self-powered polysaccharide-based hydrogels by adjusting Zn²⁺/Li⁺ bimetallic networks

Constructing robust and recyclable self-powered polysaccharide-based hydrogels by adjusting Zn²⁺/Li⁺ bimetallic networks

Advances in preparation and application of antibacterial hydrogels

Magnesium Hydroxide as a Versatile Nanofiller for 3D-Printed PLA Bone Scaffolds

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A natural polymer-based hydrogel with shape controllability and high toughness and its application to efficient osteochondral regeneration

Abstract: Hydrogels prepared from sustainable natural polymers have broad prospects in the biological field. However, their poor mechanical properties and challenges in achieving shape control have limited their application. Herein, a...

Cited by 16 publications

References 53 publications

Constructing robust and recyclable self-powered polysaccharide-based hydrogels by adjusting Zn2+/Li+ bimetallic networks

Constructing robust and recyclable self-powered polysaccharide-based hydrogels by adjusting Zn2+/Li+ bimetallic networks

Advances in preparation and application of antibacterial hydrogels

Magnesium Hydroxide as a Versatile Nanofiller for 3D-Printed PLA Bone Scaffolds

Contact Info

Product

Resources

About

Constructing robust and recyclable self-powered polysaccharide-based hydrogels by adjusting Zn²⁺/Li⁺ bimetallic networks

Constructing robust and recyclable self-powered polysaccharide-based hydrogels by adjusting Zn²⁺/Li⁺ bimetallic networks