A near-infrared fluorescent probe for Cu2+ in living cells based on coordination effect

Li, Yingyun; Sun, Mingtai; Kui, Zhang; Zhang, Yajun; Yan, Y. J.; Lei, Kepeng; Wu, Lijun; Yu, Huan; Wang, Suhua

doi:10.1016/j.snb.2016.11.118

Cited by 43 publications

(6 citation statements)

References 41 publications

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“…10). 148 A benzimidazole group was introduced to the classic hemicyanine fluorophore at the ortho-position of the hydroxyl, which subsequently coordinated with Cu 2+ , leading to the formation of a quadridentate compound at a stoichiometric ratio of 2 : 1. Optical characterization results indicated that the formation of this coordination complex could significantly quench the fluorescence at 743 nm with fast response, high selectivity and strong anti-interference capability.…”

Section: Nir Fluorescent Probes For Ionic Speciesmentioning

confidence: 99%

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

et al. 2022

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Section: Nir Fluorescent Probes For Ionic Speciesmentioning

confidence: 99%

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

et al. 2022

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“…A novel NIR fluorescent sensor based on a hydroxyl functionalized cyanine dye was reported for XL-Cu (194). 337 The fluorescence intensity centered at 743 nm was strongly quenched with the addition of Cu(II). The probe was applied to HeLa cells treated with Cu(II).…”

Section: Fluorescent Sensors For Cu(ii)mentioning

confidence: 99%

Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals

Grover,

Koblova,

Pezacki

et al. 2024

Chem. Rev.

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Although transition metals constitute less than 0.1% of the total mass within a human body, they have a substantial impact on fundamental biological processes across all kingdoms of life. Indeed, these nutrients play crucial roles in the physiological functions of enzymes, with the redox properties of many of these metals being essential to their activity. At the same time, imbalances in transition metal pools can be detrimental to health. Modern analytical techniques are helping to illuminate the workings of metal homeostasis at a molecular and atomic level, their spatial localization in real time, and the implications of metal dysregulation in disease pathogenesis. Fluorescence microscopy has proven to be one of the most promising non-invasive methods for studying metal pools in biological samples. The accuracy and sensitivity of bioimaging experiments are predominantly determined by the fluorescent metal-responsive sensor, highlighting the importance of rational probe design for such measurements. This review covers activity-and binding-based fluorescent metal sensors that have been applied to cellular studies. We focus on the essential redox-active metals: iron, copper, manganese, cobalt, chromium, and nickel. We aim to encourage further targeted efforts in developing innovative approaches to understanding the biological chemistry of redox-active metals. CONTENTS5908 8.2. Activity-Based Fluorescent Sensors for Ni(II) 5911 9. Outlook 5911 Author Information 5912 Corresponding Authors 5912

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“…31,32 For example, Li et al developed a NIR uorescence probe bearing 2-(1H-benzo[d]imidazol-2-yl)-phenol as a copper ion receptor. 33 Zhang et al described a 2-picolinic ester-based NIR probe, NIR-Cu, for monitoring Cu 2+ in vivo. 34 Tang's group developed a NIR uorescent copper probe and successfully applied it to visualize Cu 2+ in living cells, rat hippocampal tissues and zebrash models.…”

Section: Introductionmentioning

confidence: 99%

A salicylaldehyde benzoyl hydrazone based near-infrared probe for copper(ii) and its bioimaging applications

et al. 2022

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A near-infrared fluorescent probe for Cu2+ in living cells based on coordination effect

Cited by 43 publications

References 41 publications

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals

A salicylaldehyde benzoyl hydrazone based near-infrared probe for copper(ii) and its bioimaging applications

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