A near-superhydrophobic surface reduces hemolysis of blood flow in tubes

Lai, Chang Quan; Shen, Joel Chia Wei; Cheng, Wilson Chua Wei; Yap, Choon Hwai

doi:10.1039/c6ra12376g

Cited by 23 publications

(15 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Factors that have been shown to influence the water-repelling mechanism include the surface energy and roughness. 43 Comparing the WCAs obtained with those reported in the literature for some of these coatings, the values reported for NeverWet, 24–27,44–46 a static WCA ranging between 143° and 165°, a CAH in the range of 2–8° and a roughness between 2 and 6 µm compare well with the obtained values in this study. A WCA of 149–166° and a contact hysteresis was reported for HydroBead 25,45,47 and a static contact angle of 111° reported for Aculon 48 are also within range of those obtained in this study.…”

Section: Resultssupporting

confidence: 90%

“…Recent literature reported on novel coating technologies, using the NeverWet, HydroBead and Aculon coatings as the commercial reference coating. 25–28 These studies demonstrated that the presented laboratory scale coatings had enhanced abrasion resistance in comparison to these commercial coatings. 29,30 The commercial coating technologies available are often limited by the strength of the bonding between the substrate and the coating.…”

Section: Introductionmentioning

confidence: 76%

“…While a small number of previous studies, have investigated the performance of some of these coatings individually 24 , the objective in this study is to provide a coating comparison study. Some studies reported on novel coating technologies, using the NeverWet, HydroBead and Aculon coatings as the commercial reference coating [25][26][27][28] . These studies demonstrated that the presented laboratory scale coatings had enhanced abrasion resistance in comparison to commercial coatings 29,30 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of the protective performance of hydrophobic coatings applied on carbon-fibre epoxy composites

O'Connor

Dowling

2019

Journal of Composite Materials

View full text Add to dashboard Cite

Carbon–fibre epoxy composites are widely used for high-performance structural applications, where they are often exposed to harsh environments. The result of moisture ingress has been extensively studied, causing significant deterioration in the mechanical properties of these composites. This study evaluates the performance of five commercial hydrophobic coatings as protective layers, to inhibit moisture ingress into the composite. The coatings evaluated were NeverWet, HydroBead, SHC, Aculon and LiquidGlass. These coatings were characterised and compared in terms of hydrophobicity, surface energy, roughness and chemical composition. This study also evaluated two atmospheric plasma pre-treatments as a means of enhancing the adhesion performance of these coatings. The pre-treatments involved the use of an air plasma for the activation of the epoxy, as well as the plasma deposition of a nanometre thick SiOx interlayer coating. The durability and protective performance of the coatings, with and without the pre-treatments were then compared using an abrasion test as well as a water immersion study. The use of both plasma pre-treatments was found to enhance the adhesion and the abrasion performance of four out of the five coatings. Of the coatings and pre-treatments investigated, the LiquidGlass in conjunction with a SiOx-coating interlayer was found to exhibit the highest abrasion resistance. This was followed by the composite, which was plasma activated prior to the application of the Aculon coating. Only minor differences were observed when comparing the total moisture ingress (M%) of the epoxy, coated with the different hydrophobic layers. The composite coated with the Aculon and SiOx interlayer exhibited the least amount of moisture ingress, at 0.90%, compared to 1.08% of the uncoated specimen. The shear strength of epoxy composite, coated with the LiquidGlass, NeverWet and the activated Aculon combination, were within the range of the uncoated specimens, therefore the moisture ingress was reversible upon heating and no permanent damage to the epoxy–fibre interface was observed. It is concluded that, of the five coatings investigated, both the Aculon coating and LiquidGlass in combination with a SiOx interlayer coating, exhibit the greatest potential as protective layers for carbon fibre epoxy composites.

show abstract

Section: Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of the protective performance of hydrophobic coatings applied on carbon-fibre epoxy composites

O'Connor

Dowling

2019

Journal of Composite Materials

View full text Add to dashboard Cite

show abstract

“…Current investigations that test mechanical device biocompatibility and rheological damage, often investigate rates of RBC hemolysis subsequent to supraphysiological shear stress exposure, commonly studying blood obtained from healthy donors. Given that mechanical assist devices now have the capacity to minimize hemolysis [although they still operate in the supraphysiological domain of shear stress ], and oxidative stress is highly prevalent in the diseases indicated for mechanical circulatory assist, novel methods are currently being explored to characterize and minimize blood damage associated with the combined exposure to shear stress and oxygen free radicals .…”

mentioning

confidence: 99%

Oxidative Stress Increases Erythrocyte Sensitivity to Shear‐Mediated Damage

et al. 2017

View full text Add to dashboard Cite

Patients receiving mechanical circulatory support often present with heightened inflammation and free radical production associated with pre-existing conditions in addition to that which is due to blood interactions with nonbiological surfaces. The aim of this experimental laboratory study was to assess the deformability of red blood cells (RBC) previously exposed to oxygen free radicals and determine the susceptibility of these cells to mechanical forces. In the present study, RBC from 15 healthy donors were washed and incubated for 60 min at 37°C with 50 µM phenazine methosulfate (PMS; an agent that generates superoxide within RBC). Incubated RBC and negative controls were assessed for their deformability and susceptibility to mechanical damage (using ektacytometry) prior to the application of shear stress, and also following exposure to 25 different shear conditions of varied magnitudes (shear stress 1, 4, 16, 32, 64 Pa) and durations (1, 4, 16, 32, 64 s). The salient findings demonstrate that incubation with PMS impaired important indices of RBC deformability indicating altered cell mechanics by ∼19% in all conditions (pre- and postexposure to shear stress). The typical trends in shear-mediated changes in RBC susceptibility to mechanical damage, following conditioning shear stresses, were maintained for PMS incubated and control conditions. We demonstrated that free radicals hinder the ability of RBC to deform; however, RBC retained their typical mechanical response to shear stress, albeit at a decreased level compared with control following exposure to PMS. Our findings also indicate that low shear exposure may decrease cell sensitivity to mechanical damage upon subsequent shear stress exposures. As patients receiving mechanical circulatory support have elevated exposure to free radicals (which limits RBC deformability), concomitant exposure to high shear environments needs to be minimized.

show abstract

“…In the in vitro study by Kameneva et al, 20 on the contrary, a strong lowering of the temperature (hypothermia) results in a reduction of the deformability of the erythrocytes. Lai et al 21 were able to demonstrate in vitro that the use of newly developed superhydrophobic surfaces, also known as the lotus effect, allows the haemolysis level to be reduced for all areas in contact with blood since the shear stresses on these surfaces are greatly reduced. To create these surfaces, a commercially available coating (Rust-Oleum NeverWet) of micro- and nanoparticles with a thickness of 53 µm and a roughness of 2.3 µm was used.…”

Section: Methodsmentioning

confidence: 99%

Haemolysis induced by mechanical circulatory support devices: unsolved problems

Köhne

2020

Perfusion

View full text Add to dashboard Cite

Since the use of continuous flow blood pumps as ventricular assist devices is standard, the problems with haemolysis have increased. It is mainly induced by shear stress affecting the erythrocyte membrane. There are many investigations about haemolysis in laminar and turbulent blood flow. The results defined as threshold levels for the damage of erythrocytes depend on the exposure time of the shear stress, but they are very different, depending on the used experimental methods or the calculation strategy. Here, the results are resumed and shown in curves. Different models for the calculation of the strengths of erythrocytes are discussed. There are few results reported about tests of haemolysis in blood pumps, but some theoretical approaches for the design of continuous flow blood pumps according to low haemolysis have been investigated within the last years.

show abstract

A near-superhydrophobic surface reduces hemolysis of blood flow in tubes

Cited by 23 publications

References 36 publications

Evaluation of the protective performance of hydrophobic coatings applied on carbon-fibre epoxy composites

Evaluation of the protective performance of hydrophobic coatings applied on carbon-fibre epoxy composites

Oxidative Stress Increases Erythrocyte Sensitivity to Shear‐Mediated Damage

Haemolysis induced by mechanical circulatory support devices: unsolved problems

Contact Info

Product

Resources

About