A negative association between bromadiolone exposure and nestling body condition in common kestrels: management implications for vole outbreaks

Martínez‐Padilla, Jesús; López-Idiáquez, David; López-Perea, Jhon J.; Mateo, Rafael; Paz, Alfonso; Viñuela, Javier

doi:10.1002/ps.4435

Cited by 60 publications

(34 citation statements)

References 33 publications

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“…Thus, the study of the dispersal between nest-boxes, as conducted in other studies [ 47 , 54 ], would not be very informative in our case. We are confident in the reliability of our survival estimation, as we did not find any individuals breeding in the surroundings of our study area or any dispersing chicks breeding in any of the nearby nest-box populations (Villalar de los Comuneros– 112 km from our study area; San Martín de Valderaduey– 155 km from our study area) that we also study [ 58 , 59 ]. Nevertheless, for our purposes, natal dispersal is considered a cost in terms of fitness reduction, as it increases mortality [ 60 , 61 ].…”

Section: Discussionmentioning

confidence: 97%

Providing longer post-fledging periods increases offspring survival at the expense of future fecundity

et al. 2018

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The cost of reproduction is a key concept in life-history trade-offs. However, our understanding of the reproductive costs is biased towards measures of reproductive effort obtained before offspring independence. During the post-fledging dependence period (PFDP), it is well known that parents feed and protect their offspring. However, the effort devoted to this reproductive activity has never been considered in the context of of the costs of reproduction. Moreover, the potential fitness benefits and costs for offspring and parents, respectively, of the duration of the PFDP are largely unknown. We estimated the duration of the PFDP over 5 years using wild common kestrels (Falco tinnunculus) and studied its association with survival probability and future parental reproductive performance. Our results show that longer PFDPs increase the survival probability of fledglings, probably due to the benefits obtained from parental care. In addition, we found that providing longer PFDPs was associated with reduced clutch sizes but not the number of fledglings in the subsequent breeding season in males. We suggest that increased parental expenditures on offspring during the PFDP may represent a potential cost of reproduction in breeding males.

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Section: Discussionmentioning

confidence: 97%

Providing longer post-fledging periods increases offspring survival at the expense of future fecundity

et al. 2018

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“…The dogs did not display any clinical effects of their subtoxic AR concentrations in the months after exposure. Previous studies have detected reduced body condition of wildlife with sublethal ARs concentrations [29][30][31]. In addition, subtoxic ARs levels are suspected to increase susceptibility to pathogens, while others have not found such association [32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Determination of anticoagulant rodenticides in faeces of exposed dogs and in a healthy dog population

et al. 2020

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Background: Exposure to anticoagulant rodenticides (ARs) in dogs is among the most common causes of poisoning in small animal practice, but information about toxicokinetic of these rodenticides in dogs is lacking. We analysed blood and faeces from five accidentally exposed dogs and 110 healthy dogs by reversed phase ultra-high performance liquid chromatography-tandem mass spectrometry. The aim of the study was to estimate elimination of brodifacoum, bromadiolone and difenacoum after acute exposure, calculate the half-lives of these rodenticides in dogs, estimate faecal elimination in a litter of puppies born, and further to identify the extent of AR exposure in a healthy dog population. Results: Three dogs were included after single ingestions of brodifacoum; two dogs ingested bromadiolone and one dog ingested difenacoum. Maximum concentrations in faeces were found after day 2-3 for all ARs. The distribution half-lives were 1-10 days for brodifacoum, 1-2 days for bromadiolone and 10 days for difenacoum. Brodifacoum and difenacoum had estimated terminal half-lives of 200-330 days and 190 days, respectively. In contrast, bromadiolone had an estimated terminal half-life of 30 days. No clinical signs of poisoning or coagulopathy were observed in terminal elimination period. In blood, the terminal half-life of brodifacoum was estimated to 8 days. Faeces from a litter of puppies born from one of the poisoned dogs were examined, and measurable concentrations of brodifacoum were detected in all samples for at least 28 days after parturition. A cross-sectional study of 110 healthy domestic dogs was performed to estimate ARs exposure in a dog population. Difenacoum was detected in faeces of one dog. Blood and faecal samples from the remaining dogs were negative for all ARs. Conclusions: Based on the limited pharmacokinetic data from these dogs, our results suggest that ARs have a biphasic elimination in faeces using a two-compartment elimination kinetics model. We have shown that faecal analysis is suitable and reliable for the assessment of ARs exposure in dogs and a tool for estimating the AR half-lives. Half-lives of ARs could be a valuable indicator in the exposed dogs and provides important information for veterinarians monitoring AR exposure and assessment of treatment length in dogs.

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“…However, there are disadvantages in using these compounds including environmental persistence and resistance. The former was demonstrated by Martínez‐Padilla et al who revealed the presence of residues of the common anticoagulant active ingredient, bromadiolone, in nestlings of common kestrels ( Falco tinnunculus ). The latter was validated by Goulois et al in house mice ( Mus musculus ), where anticoagulant efficiency is severely hampered for some anticoagulant compounds by an introgressed mutation acquired from the Algerian mouse ( Mus spretus ).…”

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confidence: 92%

Vertebrate pest management: research for science-based solutions

2017

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A negative association between bromadiolone exposure and nestling body condition in common kestrels: management implications for vole outbreaks

Cited by 60 publications

References 33 publications

Providing longer post-fledging periods increases offspring survival at the expense of future fecundity

Providing longer post-fledging periods increases offspring survival at the expense of future fecundity

Determination of anticoagulant rodenticides in faeces of exposed dogs and in a healthy dog population

Vertebrate pest management: research for science-based solutions

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