A negative association of CTLA-4 genetic variant (rs11571317) with breast cancer risk in Moroccan population

Ighid, Nassima; Akil, Soumaya El; Elouilamine, Ezohra; Izaabel, El Hassan

doi:10.1016/j.genrep.2022.101513

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…Earlier studies have connected the rs11571317 gene to the cancer of colorectal, breast, metastatic melanoma, and non-melanoma skin cancer [15,[19][20][21][22]. This is an association-based study; however, the association studies compare the frequency of a genetic variant in disease-affected patients and healthy controls.…”

Section: Discussionmentioning

confidence: 99%

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The Variant Allele Frequency of CTLA-4 rs11571317 (−658 C/T) Polymorphism With Colorectal Cancer Susceptibility in the Saudi Population and Other Ethnic Groups

Akhtar

2023

Cureus

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The single nucleotide polymorphisms (SNPs) in the promoter region of the cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene are directly associated with the progression and onset of various human cancers. These SNPs are important prognostic biomarkers for the prediction and early onset of cancer risk. The variant frequency of the CTLA-4 rs11571317 (−658 C/T) polymorphism may be affecting the various ethnic groups differently. In the present study, the allelic frequency distribution of −658 C/T polymorphism was assessed in the population of Saudi Arabia and compared with other world populations. The data from different cancers were extracted from case-control studies in the various ethnic groups by using PubMed (MEDLINE) and similar web databases. The frequency of CTLA-4 rs11571317 (−658 C/T) variant allele (T) was observed to be 25.5% and different frequencies were found significant for India (p = 0.001), USA (p = 0.03), and China (p = 0.04), when the prevalence of Saudi Arabian population was compared to that of other population groups. The current finding reveals that there is a distinct pattern of CTLA-4 rs11571317 (−658 C/T) polymorphism variant allele in the populations of Saudi Arabia, may be because of the differences in ethnicity. The observed findings can help in the assessment of the risk for the population harboring the risk allele of rs11571317 (−658 C/T) SNP and toward their subsequent susceptibility to cancer.

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Section: Discussionmentioning

confidence: 99%

“…In this study, the prevalence rate of CTLA-4 rs11571317 −658 C>T polymorphisms was extracted from six studies [15,[18][19][20][21][22] (as shown in Table 1) and it was compared with the population of Saudi Arabia (as shown in Table 2) [18].…”

Section: Criteria Of Search Of Gene Variantsmentioning

confidence: 99%

The Variant Allele Frequency of CTLA-4 rs11571317 (−658 C/T) Polymorphism With Colorectal Cancer Susceptibility in the Saudi Population and Other Ethnic Groups

Akhtar

2023

Cureus

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STAT3 gene polymorphisms and susceptibility to breast cancer in the Moroccan population

Ighid,

El Akil,

Izaabel

2023

Egypt J Med Hum Genet

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Background Breast cancer is a complex disease due to its extremely complicated and varied etiology. It is found to be linked to improper transcription factor activation that interferes with normal breast development. Among these factors, signal transducer and activator of transcription (STAT) proteins play a crucial role in regulating gene expression and cell signaling. Specifically, STAT3, a member of the STAT family, has been found to be constitutively active in various cancer types, including breast cancer. Three STAT3 SNPs (rs744166, rs229152, and rs4796793) were widely investigated in association with cancer diseases in many populations, yet the findings were conflicting. This study seeks to evaluate the association risk of these three SNPs with breast cancer in Moroccan women. Materials and methods This case–control study consisted of 200 breast cancer cases and 200 age- and sex-matched healthy controls. The extraction was carried out from whole blood by the salting-out method. Genotypes were defined using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) and sequence-specific primer–polymerase chain reaction (SSP–PCR) methods. Results In the over-dominant model (GG–CC vs. GC), the rs4796793*GC genotype was linked to a higher risk of breast cancer among triple-negative cases. Additionally, a significant association has been revealed between HER2 and the mutant genotype of the two polymorphisms rs744166 and rs4796793. Moreover, the STAT3 rs744166*AG genotype was less common in cases with late-stage (grade III) disease. Conclusion These findings suggest that STAT3 polymorphisms are associated with triple-negative breast cancer and HER2+ type; the top two lethal breast cancer in Moroccans.

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A negative association of CTLA-4 genetic variant (rs11571317) with breast cancer risk in Moroccan population

Cited by 2 publications

References 41 publications

The Variant Allele Frequency of CTLA-4 rs11571317 (−658 C/T) Polymorphism With Colorectal Cancer Susceptibility in the Saudi Population and Other Ethnic Groups

The Variant Allele Frequency of CTLA-4 rs11571317 (−658 C/T) Polymorphism With Colorectal Cancer Susceptibility in the Saudi Population and Other Ethnic Groups

STAT3 gene polymorphisms and susceptibility to breast cancer in the Moroccan population

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