A negative energy balance during the peri-implantational period reduces dam IGF-1 but does not alter progesterone or pregnancy-specific protein B (PSPB) or fertility in suckled cows

Noya, Agustí; Casasús, I.; Rodríguez-Sánchez, J.A.; Ferrer, Javier; Sanz, A.

doi:10.1016/j.domaniend.2019.106418

Cited by 9 publications

(14 citation statements)

References 42 publications

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“…Briefly, the control group (CONTROL, 574 ± 8.9 kg live weight (LW); 2.80 ± 0.038 body condition score (BCS) on a 5 point scale [20]) was fed a diet that supplied 100% of the estimated energy requirements for cow maintenance, lactation, and gestation; and the nutrient-restricted group (SUBNUT, 568 ± 7.6 kg LW; 2.86 ± 0.032 BCS) received 65% of their requirements. After this treatment phase, the CONTROL group maintained its LW and BCS (583 ± 8.6 kg LW; 2.90 ± 0.040 BCS), whereas they decreased in SUBNUT animals (538 ± 7.2 kg LW; 2.65 ± 0.033 BCS, p < 0.001), reported by Noya et al [21]. All dams were fed 100% of the requirements during the remainder of gestation and the next lactation, using the same total mixed ration described above.…”

Section: Management During Cow Gestation (Maternal Nutrition Treatmensupporting

confidence: 53%

“…Maternal nutrient restriction during early gestation reduces the proliferation of ovarian germ-cells and alters the expression of genes that regulate apoptosis in the follicle and granulosa cells, both mechanisms contributing to reduce the number of ovarian primordial follicles [37]. Additionally, we hypothesize that the differences found in IGF-1 concentrations between CONTROL and SUBNUT cows during early pregnancy, which we observed in an earlier phase of this study [21], could have resulted in subsequent changes in fetal hormone levels and in its metabolic pathways, which in turn may have altered gene expression in fetal gonads [38]. Several studies associated a high antral follicle count with improved reproductive efficiency [9,25,35,39], whereas a lower follicle count was related to a reduced lifetime reproductive capacity [40].…”

Section: Heifer Reproductive Performancementioning

confidence: 61%

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Effects of Developmental Programming Caused by Maternal Nutrient Intake on Postnatal Performance of Beef Heifers and Their Calves

Noya

Casasús

Ferrer

et al. 2019

Animals

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In this study, we evaluated the effects of maternal subnutrition in early pregnancy on the growth and reproductive performance of female offspring during their rearing, first gestation, and lactation. We inseminated 21 Parda and 15 Pirenaica multiparous cows and assigned them to a CONTROL (100% of nutrition requirements) or SUBNUT (65%) diet until day 82 of gestation. Cows were fed 100% requirements afterward. During the rearing of female offspring, growth, physiological profiles and ovarian follicular dynamic were studied. At 16 months old, heifers were inseminated. After first calving, dam–calf weights were recorded during lactation. Heifers born from CONTROL cows were heavier at weaning (four months old) than heifers born from SUBNUT cows, but this difference disappeared at the end of rearing and during the first gestation and lactation periods. All heifers reached puberty at a similar age and live weight. During rearing, SUBNUT heifers had higher concentrations of non-esterified fatty acids, urea, and cholesterol and a lower antral follicle count than CONTROL, but no difference was found in their fertility rate. After heifer first calving, dam–calf weights were similar among groups. In conclusion, maternal undernutrition reduced offspring postnatal gains at weaning, compromising metabolic status and follicle population during rearing but did not impair performance in the first gestation and lactation periods of beef heifers.

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Section: Management During Cow Gestation (Maternal Nutrition Treatmensupporting

confidence: 53%

Section: Heifer Reproductive Performancementioning

confidence: 61%

Effects of Developmental Programming Caused by Maternal Nutrient Intake on Postnatal Performance of Beef Heifers and Their Calves

Noya

Casasús

Ferrer

et al. 2019

Animals

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“…Contrary to the findings of this study, for Serrano-Pérez (2020) found that undernourishment did not affect pregnancy in the first week of gestation, as well progesterone levels (Stephenson et al, 2018;Noya et al, 2020). Sartori et al (2016) showed that Gyr cows had a decrease in blastocyst rate (46.9 Vs. 25.7%) during dry period, in which a diet of 1.7 over the maintenance was offered, for more than 60 days.…”

Section: Discussioncontrasting

confidence: 86%

Effect of the Strategic Supplementation for Producing Embryos of Native Hartón del Valle Heifers

Riascos-Vallejos¹,

Reyes-González

Medina-Mesa³

et al. 2021

American Journal of Animal and Veterinary Sciences

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“…The optimal timing of embryo flushing seems to be outside of the deep NEB period, as was also confirmed by Stadnik et al (2017), when they observed that timing of embryo transfer in the later postpartum period resulted in greater ovarian activity and embryo yield compared to early lactation periods. Noya et al (2020) made the opposite finding in their nutritional experiment. Authors observed better functioning ovaries in the group of cows fed with energy-deficient feed and therefore experiencing deeper negative energy balance compared to the overfed group.…”

Section: Discussionmentioning

confidence: 93%

Cow metabolic status assessed from fat/protein ratio in milk affected ovarian response and number of transferable embryos after superovulation

Stádník¹,

Ducháček²,

Pytlík³

et al. 2022

Czech J. Anim. Sci.

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This work aimed to evaluate the quantity and the quality of flushed embryos based on the metabolic status of dairy cows, lactation number, and size of the ovaries. Fifty-nine Holstein cows on 1st to 5th lactation were enrolled in the experiment. Monitoring took place during the period from October to November and from March to June. Cows with corpus luteum were included for the hormonal treatment – superovulation and timed insemination. The cow was inseminated, resp. re-inseminated, during the induced heat with insemination doses from one bull from the same batch. Embryo flushing was performed on the 7th day after the first insemination. We isolated individual embryos after flushing, and morphologically evaluated them under a stereo microscope. The metabolic status of tested cows was determined based on the ratio between fat and protein in milk around the period of embryo flushing (< 1.1; 1.1–1.3; > 1.3). Data about fat and protein content were taken from milking parlour records. Data were evaluated in SAS v9.4 with GLM procedure. The results of our study showed that there is a significant relationship between the fat/protein ratio and the total number of flushed embryos, resp. the number of transferable embryos. The highest number of flushed and transferable embryos were collected from the group of cows with fat/protein ratio between 1.1–1.3. The fat/protein ratio within these values represents cows in an optimal metabolic state. We also observed a significant positive relationship between the size of the ovaries and the number of flushed and transferable embryos. Lactation number did not significantly affect monitored parameters. The assessment of the fat/protein ratio might become a useful tool for the evaluation of cows selected for embryo transfer. Our findings could be used to improve the efficacy of the superovulation system, with the aim to extract the maximum number of transferable embryos.

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A negative energy balance during the peri-implantational period reduces dam IGF-1 but does not alter progesterone or pregnancy-specific protein B (PSPB) or fertility in suckled cows

Cited by 9 publications

References 42 publications

Effects of Developmental Programming Caused by Maternal Nutrient Intake on Postnatal Performance of Beef Heifers and Their Calves

Effects of Developmental Programming Caused by Maternal Nutrient Intake on Postnatal Performance of Beef Heifers and Their Calves

Effect of the Strategic Supplementation for Producing Embryos of Native Hartón del Valle Heifers

Cow metabolic status assessed from fat/protein ratio in milk affected ovarian response and number of transferable embryos after superovulation

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