A neglected infection in literature: Childhood musculoskeletal tuberculosis – A bibliometric analysis of the most influential papers

Held, Michael; Bruins, Marie-Fien; Castelein, Sophie; Laubscher, Maritz; Dunn, Robert; Hoppe, Sven

doi:10.4103/ijmy.ijmy_99_17

Cited by 10 publications

(4 citation statements)

References 1 publication

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“…Furthermore, the bacteria may destroy bone or joint tissue in the affected area, this may result in deformity and limited movement. The bacteria may occasionally cause pus collections or abscesses in the bone or joint [28].…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Pediatric Tuberculosis Patients at Simpang Lima Gumul Hospital, Kediri, East Java

Rika Oktania Sari,

Bayu Prabowo

2023

a-jhr

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Introduction: Pediatric tuberculosis can cause a variety of problems, including growth failure, disability, and death. In 2021, WHO recorded 10.6 million individuals had tuberculosis globally, with pediatric tuberculosis accounting for 11% of these cases. Indonesia is the second highest high-burden country for tuberculosis, according to the WHO. Children with tuberculosis often present non-specific and uncommon symptoms, making diagnosis challenging and frequently delayed. This study aims to present an overview of the characteristics of pediatric tuberculosis patients at Simpang Lima Gumul Hospital in Kediri, East Java. Material and Methods: This was a descriptive retrospective study with a cross-sectional method. Pediatric tuberculosis patients who received treatment at the Simpang Lima Gumul Hospital in Kediri, East Java, were the subject of research. We compiled pediatric tuberculosis patients' demographic data and clinical characteristics using medical records. Results: Sixty-one children included in the study. Most of them were male (56%) between 1 to 5 years old (52%). Seventy-two percent had a positive tuberculin skin test; chronic cough was noted in 69% of cases. An adult contact history of tuberculosis was reported in 64% of cases, while 61% had radiographic findings from TB. 52% also had fever, 51% had lymphadenopathy, and 72% had good nutritional status. Conclusion: Tuberculosis occurs most commonly in male children 1 to 5 years of age. The most common symptoms of pediatric tuberculosis include a positive tuberculin skin test, chronic cough, contact with adults with tuberculosis, positive radiographic findings, fever, and lymphadenopathy.

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Section: Discussionmentioning

confidence: 99%

Characteristics of Pediatric Tuberculosis Patients at Simpang Lima Gumul Hospital, Kediri, East Java

Rika Oktania Sari,

Bayu Prabowo

2023

a-jhr

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“…8 Extrapulmonary TB can account for up to 20% of all TB cases, with MSK TB accounting for 10-35% of these. 9 The purpose of this retrospective study was to provide the most common clinical presentation of MSK TB in the paediatric patient to provide recommendations for diagnostic workup and treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Musculoskeletal tuberculosis (MSK TB) is a disease entity that often mimics other orthopaedic conditions in its radiographic and clinical presentation, which can delay diagnosis and treatment. While MSK TB accounts for 9.7% of all extra-pulmonary cases in the United States, this percentage is much higher in endemic regions like India and South Africa. 1 Approximately 20 children each year are diagnosed with and treated for MSK TB at our institution.…”

Section: Introductionmentioning

confidence: 99%

Tuberculosis of the extra-axial skeleton in paediatric patients

Vajapey

Horn

2021

SA orthop. j.

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BACKGROUND: Musculoskeletal tuberculosis (MSK TB) is a disease entity that often mimics other orthopaedic conditions in its radiographic and clinical presentation, which can delay diagnosis and treatment. The purpose of this study is to examine the clinical and radiographic presentation as well as the accuracy of various diagnostic tests, treatment, complications and outcome in paediatric patients diagnosed with MSK TB. We aim to provide insight into typical presenting features in order to expedite diagnosis in this perplexing disease. METHODS: We retrospectively reviewed 77 consecutive patients with extra-axial MSK TB treated at our institution over a ten-year period from 2008 to 2018. We collected data on initial clinical presentation, laboratory values, radiographic findings, diagnostic testing, treatment and outcomes. We performed quantitative and qualitative analysis to look for patterns in presentation that can help with diagnosis and factors affecting the clinical outcomes. RESULTS: The most common clinical presentation was pain of the affected limb. Constitutional symptoms were uncommon. Our patients presented with thrombocytosis and anaemia, but normal white cell counts. Inflammatory markers were mildly elevated. Of diagnostic tests employed, the Mantoux skin test yielded the most positive results (70%) followed by tissue PCR (53%). The hip was most frequently involved, followed by the knee and elbow. Most patients presented with normal appearing X-rays. We had a medical compliance rate of 94% with all patients followed up to completion of treatment having resolution of active disease. Thirty-nine per cent of our patients had residual joint stiffness or deformity following completion of treatment, ranging from ankylosis to mildly decreased joint range. CONCLUSION: Patients with MSK TB usually present with non-specific symptoms and signs, and a high index of suspicion should be maintained in endemic areas. Typical haematological findings are an elevated ESR and CRP accompanied by anaemia and thrombocytosis. Radiographs at presentation are non-specific in more than 50% of patients. A combination of diagnostic modalities should be employed as no single test is 100% sensitive or specific. Compliance with medical treatment reliably leads to resolution of the disease. Residual joint pathology is common and needs to be addressed secondarily. Level of evidence: Level 4 Keywords: musculoskeletal tuberculosis, paediatric tuberculosis, joints, anti-tuberculosis treatment, deformity, GeneXpert

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“…Bibliometric studies to date have evaluated TB in general 7 or associated with some other disease 8 without making a distinction by age group; and even though there are studies that make this distinction, they only focus on some associated comorbidity. 9 In this study, therefore, in the present study, we have evaluated TB in general 7 or associated with some other disease [8] without making a distinction by age group; and even though there are studies that make this distinction, they only focus on some associated comorbidity. 10 Therefore, in this study, a scientometric analysis was performed with the aim of describing the publication trends and bibliometric indicators of publications related to TB in the pediatric population.…”

Section: Introductionmentioning

confidence: 99%

Overview, Trends and Mapping of The Scientific Production on Childhood Tuberculosis: A Scientometric Study

Espinoza-Carhuancho,

Medina,

Mauricio-Vilchez

et al. 2024

Natl J Community Med

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Background: Tuberculosis in children is highly prevalent and is considered community transmission by an infected adult. This study analyzed childhood tuberculosis literature from 2018 to 2023 on Scopus. Methodology: The study was an observational, retrospective design with a bibliometric approach focusing on the scientific production on childhood tuberculosis. A trend analysis and mapping of the literature published in Scopus was performed. The following selection criteria were applied: All types of papers published in Scopus during the study period were included. Papers published between 2018 and 2023 were included. Papers had to be focused on childhood tuberculosis. Results: Antoni Diez Noguera-Julián from SJD Barcelona Children’s Hospital had a field-weighted citation impact of 10.89. Anneke Catharina Hesseling and James Alexander Seddon had the highest output. The University of Melbourne and the University of Barcelona had high field-weighted citation impacts. Despite the United States’ high production, Spain and Australia showed significant influence. The “International Journal of Tuberculosis and Lung Disease” led in production. Conclusions: A bibliometric study on childhood tuberculosis literature from 2018-2023 highlighted Antoni Diez Noguera-Julián’s significant citation impact and the high output of Anneke Catharina Hesseling and James Alexander Seddon. Despite the U.S.'s high production, Spain and Australia showed significant influence.

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A neglected infection in literature: Childhood musculoskeletal tuberculosis – A bibliometric analysis of the most influential papers

Cited by 10 publications

References 1 publication

Characteristics of Pediatric Tuberculosis Patients at Simpang Lima Gumul Hospital, Kediri, East Java

Characteristics of Pediatric Tuberculosis Patients at Simpang Lima Gumul Hospital, Kediri, East Java

Tuberculosis of the extra-axial skeleton in paediatric patients

Overview, Trends and Mapping of The Scientific Production on Childhood Tuberculosis: A Scientometric Study

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