2002
DOI: 10.1067/mai.2002.120551
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A neonatal swine model for peanut allergy

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Cited by 116 publications
(77 citation statements)
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“…For assessment of potential allergenicity, the intraperitoneal route of exposure is also studied in mice (Hilton et al 1997;Dearman et al 2000 ;Kimber et al 2000). Appropriate domestic models that are considered to be useful models to predict the potential allergenicity of novel proteins or that can provide comprehensive understanding of IgE-mediated disease mechanisms are the atopic dog model (Ermel et al 1997) and the swine model (Helm et al 2002). For the rat, studies on sensitization to food proteins in the presence of an adjuvant have also been described (Atkinson et al 1996;Atkinson and Miller 1994).…”
Section: Resultsmentioning
confidence: 99%
“…For assessment of potential allergenicity, the intraperitoneal route of exposure is also studied in mice (Hilton et al 1997;Dearman et al 2000 ;Kimber et al 2000). Appropriate domestic models that are considered to be useful models to predict the potential allergenicity of novel proteins or that can provide comprehensive understanding of IgE-mediated disease mechanisms are the atopic dog model (Ermel et al 1997) and the swine model (Helm et al 2002). For the rat, studies on sensitization to food proteins in the presence of an adjuvant have also been described (Atkinson et al 1996;Atkinson and Miller 1994).…”
Section: Resultsmentioning
confidence: 99%
“…Well-characterized animal models would clearly facilitate efforts to understand the basic pathophysiology occurring during anaphylaxis; to determine the interactions between various cell types; to elucidate effects of mediators, cytokines, and chemokines released during an anaphylactic response; and to delineate better therapeutic strategies. Recently, animal models that appear reflective of anaphylaxis in human subjects have been established in mice, 43 dogs, 44 and pigs, 45 but better models are needed.…”
Section: Research Needsmentioning
confidence: 99%
“…In the past decade the studies were initiated in small animal models including guinea pig (Piacentini et al, 1994), rat (Knippels et al, 1998), and mouse (Li et al, 2000). Recently, larger animals as dogs (Buchanan and Frick, 2002) and pigs (Helm et al, 2002), that more closely mimic human physiology, anatomy, and allergic disease have been used for food allergy investigation. In relation to mice, several strains have been used for food allergy investigation (i.e.…”
mentioning
confidence: 99%