A nerve conduit filled with Wnt5a‐loaded fibrin hydrogels promotes peripheral nerve regeneration

Liu, Yijun; Chen, Xiaofeng; Zhou, Liping; Rao, Feng; Zhang, Dianying; Wang, Yanhua

doi:10.1111/cns.13752

Cited by 13 publications

(8 citation statements)

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“…Natural polymers are either protein-based or polysaccharide-based. The former includes collagen, thrombin [6], and fibroin (the protein constituent of silk) [7]. The latter includes cellulose [8], chitin [9], and chitosan [10].…”

Section: Nerve Guide Conduitsmentioning

confidence: 99%

Nerve guide conduits, nerve transfers, and local and free muscle transfer in facial nerve palsy

Shoman

2023

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of review To highlight the recent literature on reinnervation options in the management of facial nerve paralysis using nerve conduits, and nerve and muscle transfers. Recent findings Engineering of natural and synthetic nerve conduits has progressed and many of these products are now available on the market. The use of the masseter nerve has become more popular recently as a choice in nerve transfer procedures due to various unique advantages. Various authors have recently described mimetic muscle reinnervation using more than one nerve transfer, as well as dual and triple innervation of free muscle transfer. Summary The ideal nerve conduit continues to be elusive, however significant progress has been made with many natural and synthetic materials and designs tested and introduced on the market. Many authors have modified the classic approaches in motor nerve transfer, as well as local and free muscle transfer, and described new ones, that aim to combine their advantages, particularly the simplification to a single stage and use of multiple reinnervation to the mimetic muscles. These advances are valuable to the reconstructive surgeon as powerful tools that can be tailored to the unique challenges of patients with facial nerve palsy looking for dynamic reanimation options.

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Section: Nerve Guide Conduitsmentioning

confidence: 99%

Nerve guide conduits, nerve transfers, and local and free muscle transfer in facial nerve palsy

Shoman

2023

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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“…In an SCI model, a 3D fibrin scaffold provided an effective matrix for host cell invasion and vascular reconstruction, thereby promoting axonal regrowth and recovery of locomotor function [105]. Following sciatic nerve injury, a Wnt5a-loaded fibrin conduit was also reported to promote neurotrophin secretion and nerve regeneration [106].…”

Section: Fibrinmentioning

confidence: 99%

Bio-Scaffolds as Cell or Exosome Carriers for Nerve Injury Repair

Poongodi

Chen

Yang

et al. 2021

IJMS

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Central and peripheral nerve injuries can lead to permanent paralysis and organ dysfunction. In recent years, many cell and exosome implantation techniques have been developed in an attempt to restore function after nerve injury with promising but generally unsatisfactory clinical results. Clinical outcome may be enhanced by bio-scaffolds specifically fabricated to provide the appropriate three-dimensional (3D) conduit, growth-permissive substrate, and trophic factor support required for cell survival and regeneration. In rodents, these scaffolds have been shown to promote axonal regrowth and restore limb motor function following experimental spinal cord or sciatic nerve injury. Combining the appropriate cell/exosome and scaffold type may thus achieve tissue repair and regeneration with safety and efficacy sufficient for routine clinical application. In this review, we describe the efficacies of bio-scaffolds composed of various natural polysaccharides (alginate, chitin, chitosan, and hyaluronic acid), protein polymers (gelatin, collagen, silk fibroin, fibrin, and keratin), and self-assembling peptides for repair of nerve injury. In addition, we review the capacities of these constructs for supporting in vitro cell-adhesion, mechano-transduction, proliferation, and differentiation as well as the in vivo properties critical for a successful clinical outcome, including controlled degradation and re-absorption. Finally, we describe recent advances in 3D bio-printing for nerve regeneration.

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“…Indeed, peripheral nerve injury (PNI) is a significant clinical problem that affects millions of people annually and makes up around 2% of all trauma cases. [1][2][3] In particular, severe PNIs, such as nerve defects, can result in substantial sensory loss and motor impairment. Patients who suffer from such injuries may be permanently incapacitated, which would be extremely difficult for their family as well as for society at large.…”

Section: Introductionmentioning

confidence: 99%

“…7,8 As of right now, autologous nerve transplantation is still the best option for treating PNI. 1,2,9 Nevertheless, this strategy is constrained by elements including donor site morbidity, size mismatch between donor and recipient nerves, and unsatisfactory prognosis. 2,10 To overcome these limitations, researchers have developed artificial nerve conduits that hold the potential to replace autologous nerve transplantation as the preferred treatment standard in the future.…”

Section: Introductionmentioning

confidence: 99%

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Combining PLGA microspheres loaded with Liver X receptor agonist GW3965 with a chitosan nerve conduit can promote the healing and regeneration of the wounded sciatic nerve

Zhong,

Li,

Chen

et al. 2024

J Biomed Mater Res

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Globally, peripheral nerve injury (PNI) is a common clinical issue. Successfully repairing severe PNIs has posed a major challenge for clinicians. GW3965 is a highly selective LXR agonist, and previous studies have demonstrated its positive protective effects in both central and peripheral nerve diseases. In this work, we examined the potential reparative effects of GW3965‐loaded polylactic acid co‐glycolic acid microspheres in conjunction with a chitosan nerve conduit for peripheral nerve damage. The experiment revealed that GW3965 promoted Schwann cell proliferation and neurotrophic factor release in vitro. In vivo experiments conducted on rats showed that GW3965 facilitated the restoration of motor function, promoted axon and myelin regeneration in the sciatic nerve, and enhanced the microenvironment of nerve regeneration. These results offer a novel therapeutic approach for the healing of nerve damage. Overall, this work provides valuable insights and presents a promising therapeutic strategy for addressing PNI.

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A nerve conduit filled with Wnt5a‐loaded fibrin hydrogels promotes peripheral nerve regeneration

Abstract: Yijun Liu, Xiao-feng Chen, and Yan-hua Wang contributed equally to this article.

Cited by 13 publications

References 50 publications

Nerve guide conduits, nerve transfers, and local and free muscle transfer in facial nerve palsy

Nerve guide conduits, nerve transfers, and local and free muscle transfer in facial nerve palsy

Bio-Scaffolds as Cell or Exosome Carriers for Nerve Injury Repair

Combining PLGA microspheres loaded with Liver X receptor agonist GW3965 with a chitosan nerve conduit can promote the healing and regeneration of the wounded sciatic nerve

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