A network meta-analysis for efficacies and toxicities of different therapeutic regimens in the treatment of advanced nasopharyngeal carcinoma

Li, Tingyu; Yang, Fan; Ma, Kening; Lv, Lijie

doi:10.1007/s00405-020-06593-5

Cited by 1 publication

(1 citation statement)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study suggested that chemotherapy decreased OS of patients with stage I NPC. Firstly, chemoradiotherapy increased toxicity reactions compared to radiotherapy ( 12 , 13 ). Severe hematological adverse events might be life-threatening.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Chemotherapy in Survival of Stage I Nasopharyngeal Carcinoma

Huang

Jiang

et al. 2021

Front. Oncol.

View full text Add to dashboard Cite

PurposeTo identify whether chemoradiotherapy improves survival of stage I nasopharyngeal carcinoma (NPC).Materials and MethodsNPC patients were extracted from the Surveillance, Epidemiology, and End Results database between 2010 and 2015. Pathologically confirmed stage T1N0M0 (the 7th edition AJCC) were investigated. Overall survival (OS) and cancer-specific survival (CSS) were compared between the radiotherapy and chemoradiotherapy groups using the Kaplan-Meier method and propensity score matching (PSM) analyses.ResultsThis study included 91 (40.27%) patients in the chemoradiotherapy group and 135 (59.73%) patients in the radiotherapy group. Before PSM, chemoradiotherapy was associated with worse 3-year OS (74.31 vs 87.23%; P = 0.025) and 5-year OS (64.28 vs 83.12%; P = 0.001) compared to those associated with radiotherapy. Similarly, chemoradiotherapy showed worse 3-year CSS (87.01 vs 96.97%; P = 0.028) and 5-year CSS (80.39 vs. 96.97%; P = 0.002) than those of radiotherapy. After PSM, chemoradiotherapy revealed worse 5-year OS (63.10 vs. 82.49%; P = 0.031) and CSS (80.95 vs. 93.70%; P = 0.016) than radiotherapy. The multivariate regression analysis revealed that chemoradiotherapy was an independent risk prognostic factor for OS and CSS before and after PSM.ConclusionRadiotherapy alone is recommended for stage I NPC patients.

show abstract

Section: Discussionmentioning

confidence: 99%