A Network Meta-Analysis of 12,116 Individuals From Randomized Controlled Trials in the Treatment of Depression After Acute Coronary Syndrome

Shao, Pengfei; Tang, Ansel Shao Pin; Lim, Gina; Chin, Yip Han; Shengting, Aaron; Ng, Cheng Han; Yong, Jie Ning; Tan, Darren Jun Hao; Tay, Phoebe Wen Lin; Chan, Yu Yi; Lee, Chloe Wen-Min; Devi, K.S.; Ong, Colin Eng Choon; Foo, Roger; Tan, Huay Cheem; Chan, Mark Y; Man, Roger Ho Chun; Loh, Poay-Huan; Chew, Nicholas

doi:10.1016/s0735-1097(22)02065-4

Cited by 2 publications

(4 citation statements)

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“…In this retrospective, observational cohort, we studied adult patients, aged 21 years and older, who presented with AMI from 1 January 2014 to 31 March 2021 to a tertiary percutaneous coronary intervention (PCI)-capable hospital in Singapore, [20][21][22] which, along with two other spoke hospitals, make up the Western network that provides PCI services to the Western region in Singapore. 23,24 All patients presented with either ST-elevation myocardial infarction (STEMI) or non-ST elevation myocardial infarction (NSTEMI), and were directed to the Emergency Department at the hub hospital or via interhospital transfers from the spoke hospitals. These patients were allocated into two study groups according to the presence of hepatic steatosis.…”

Section: Setting and Designmentioning

confidence: 99%

Hepatic steatosis and advanced hepatic fibrosis are independent predictors of long‐term mortality in acute myocardial infarction

Chin

Lim

Kong

et al. 2023

Diabetes Obesity Metabolism

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Aim To examine the prevalence and prognosis of hepatic steatosis and fibrosis in post‐acute myocardial infarction (AMI) patients. Methods Patients presenting with AMI to a tertiary hospital were examined from 2014 to 2021. Hepatic steatosis and advanced hepatic fibrosis were determined using the Hepatic Steatosis Index and fibrosis‐4 index, respectively. The primary outcome was all‐cause mortality. Cox regression models identified determinants of mortality after adjustments and Kaplan–Meier curves were constructed for all‐cause mortality, stratified by hepatic steatosis and advanced fibrosis. Results Of 5765 patients included, 24.8% had hepatic steatosis, of whom 41.7% were diagnosed with advanced fibrosis. The median follow‐up duration was 2.7 years. Patients with hepatic steatosis tended to be younger, female, with elevated body mass index and an increased metabolic burden of diabetes, hypertension and hyperlipidaemia. Patients with hepatic steatosis (24.6% vs. 20.9% mortality, P < .001) and advanced fibrosis (45.6% vs. 32.9% mortality, P < .001) had higher all‐cause mortality rates compared with their respective counterparts. Hepatic steatosis (adjusted hazard ratio 1.364, 95% CI 1.145‐1.625, P = .001) was associated with all‐cause mortality after adjustment for confounders. Survival curves showed excess mortality in patients with hepatic steatosis compared with those without (P = .002). Conclusions Hepatic steatosis and advanced fibrosis have a substantial prevalence among patients with AMI. Both are associated with mortality, with an incrementally higher risk when advanced fibrosis ensues. Hepatic steatosis and fibrosis could help risk stratification of AMI patients beyond conventional risk factors.

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Section: Setting and Designmentioning

confidence: 99%

Hepatic steatosis and advanced hepatic fibrosis are independent predictors of long‐term mortality in acute myocardial infarction

Chin

Lim

Kong

et al. 2023

Diabetes Obesity Metabolism

Self Cite

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“…While the prevention of medical complications undoubtedly demands clinical attention, so do the potential psychiatric complications associated with cardiovascular disease (CVD). Depression and anxiety in patients post-MI are consistently associated with adverse health outcomes 5–10 . Nevertheless, in the midst of managing complicated and multifaceted care post-MI, clinicians often overlook mental health concerns due to time constraints and lack of knowledge, leaving patients untreated and at risk 11 …”

Section: Introductionmentioning

confidence: 99%

“…It was later found that patients with MI have an additional 50% increased risk of stroke if they experience depression 6 . Mental health disorders, including MDD, are also associated with a higher risk of 30-day readmission after MI and a 1.6% increase in adverse cardiovascular events 7,8 . Post-MI depression is associated with sedentary lifestyles and treatment nonadherence as well 9,10 …”

Section: Introductionmentioning

confidence: 99%

“…Depression and anxiety in patients post-MI are consistently associated with adverse health outcomes. [5][6][7][8][9][10] Nevertheless, in the midst of managing complicated and multifaceted care post-MI, clinicians often overlook mental health concerns due to time constraints and lack of knowledge, leaving patients untreated and at risk. 11 Major depressive disorder (MDD) is a leading cause of disability in the United States (US).…”

Section: Introductionmentioning

confidence: 99%

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Mental Health Is Heart Health: Adjusting Clinical Guidelines for Depression After Myocardial Infarction

Hardoy,

Shipley,

Kramer

et al. 2023

Harv Rev Psychiatry

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A Network Meta-Analysis of 12,116 Individuals From Randomized Controlled Trials in the Treatment of Depression After Acute Coronary Syndrome

Cited by 2 publications

References 0 publications

Hepatic steatosis and advanced hepatic fibrosis are independent predictors of long‐term mortality in acute myocardial infarction

Hepatic steatosis and advanced hepatic fibrosis are independent predictors of long‐term mortality in acute myocardial infarction

Mental Health Is Heart Health: Adjusting Clinical Guidelines for Depression After Myocardial Infarction

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